Detalhe da pesquisa
1.
Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists.
Bioorg Med Chem Lett
; 27(15): 3272-3278, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28642104
2.
Discovery and SAR of 5-aminooctahydrocyclopentapyrrole-3a-carboxamides as potent CCR2 antagonists.
Bioorg Med Chem Lett
; 24(4): 1239-42, 2014 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23916257
3.
Novel 2-aminooctahydrocyclopentalene-3a-carboxamides as potent CCR2 antagonists.
Bioorg Med Chem Lett
; 23(1): 351-4, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23182090
4.
Identification of a dual δ OR antagonist/µ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d).
Bioorg Med Chem Lett
; 22(14): 4869-72, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22695132
5.
Overcoming hERG activity in the discovery of a series of 4-azetidinyl-1-aryl-cyclohexanes as CCR2 antagonists.
Bioorg Med Chem Lett
; 21(18): 5577-82, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21783361
6.
Discovery of an Isothiazole-Based Phenylpropanoic Acid GPR120 Agonist as a Development Candidate for Type 2 Diabetes.
ACS Med Chem Lett
; 8(9): 947-952, 2017 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28947942
7.
Direct dehydrative cross-coupling of tautomerizable heterocycles with alkynes via Pd/Cu-catalyzed phosphonium coupling.
Chem Commun (Camb)
; 46(8): 1347-9, 2010 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-20449299
8.
Ex vivo delta opioid receptor autoradiography: CNS receptor occupancy of two novel compounds over their antihyperalgesic dose range.
Pharmacol Biochem Behav
; 96(2): 130-5, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20438745
9.
Diabetogenic effect of a series of tricyclic delta opioid agonists structurally related to cyproheptadine.
Toxicol Sci
; 117(2): 493-504, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20616206
10.
Design of peptide agonists.
Methods Enzymol
; 343: 73-91, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-11665596
11.
Identification of potent phenyl imidazoles as opioid receptor agonists.
Bioorg Med Chem Lett
; 16(9): 2505-8, 2006 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16483774
12.
Michael addition reactions between chiral equivalents of a nucleophilic glycine and (S)- or (R)-3-[(E)-enoyl]-4-phenyl-1,3-oxazolidin-2-ones as a general method for efficient preparation of beta-substituted pyroglutamic acids. Case of topographically controlled stereoselectivity.
J Am Chem Soc
; 127(43): 15296-303, 2005 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-16248672
13.
Regioselective and stereoselective nucleophilic ring opening reactions of a phenyl-substituted aziridine: enantioselective synthesis of beta-substituted tryptophan, cysteine, and serine derivatives.
J Org Chem
; 67(4): 1399-402, 2002 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-11846696
14.
Virtually complete control of simple and face diastereoselectivity in the Michael addition reactions between achiral equivalents of a nucleophilic glycine and (S)- or (R)-3-(E-enoyl)-4-phenyl-1,3-oxazolidin-2-ones: practical method for preparation of beta-substituted pyroglutamic acids and prolines.
J Org Chem
; 69(15): 4984-90, 2004 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-15255725
15.
Stereoselective synthesis of dipeptide beta-turn mimetics: 7-benzyl and 8-phenyl substituted azabicyclo[4.3.0]nonane amino acid esters.
J Org Chem
; 67(18): 6353-60, 2002 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-12201753