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1.
Ann Vasc Surg ; 89: 28-35, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-35339599

RESUMO

BACKGROUND: The aim of this study is to compare how instructions for use (IFU) affected perioperative and intermediate term outcomes for common iliac artery aneurysms (CIAA) treated with the Gore Excluder iliac branch endoprosthesis (IBE). METHODS: A retrospective analysis was performed of all patients treated at two affiliated academic centers from September 2016 to May 2020. Outcomes were compared between IFU and nonIFU IBE cases. Criteria for nonIFU included: (1) use with a nonGore aortic endoprosthesis (n = 10), (2) isolated IBE (n = 3), and (3) requiring nondedicated covered stents for additional extension into a more suitable landing zone in the ipsilateral internal iliac artery or one of its branches (n = 11). Perioperative and intermediate term data were collected for both groups. The primary end points were free from the major adverse event (MAE) at 30 days and primary effectiveness at 1 year. RESULTS: A total of 51 CIAA (39 patients) were treated with an IBE. Overall, 15 patients were treated under IFU and 24 under nonIFU. The IFU group mean age was older (72 vs. 67 years, P = 0.03), and males (97%) were primarily treated. Comorbidities were similar except nonIFU had more patients with previous endovascular abdominal aortic aneurysm repair on presentation (0 vs. 4 cases, P = 0.04). Procedure (178 vs. 264 min, P = 0.02) and fluoroscopy (52 vs. 74 min, P = 0.04) times were longer in the nonIFU group. Technical success was 100% for both groups, and there was no difference in device related reintervention at 30 days (0 vs. 1, P = 0.44). There was no MAE in either group at 30 days. Intervention for any endoleak was similar between the groups (2 vs. 3, P = 0.94). Percent CIAA sac regression was similar between the groups (19% vs. 18%, P = 0.21). There was no difference for primary effectiveness at 1 year (93% vs. 92%, P = 0.85). There was one death per group at one year not related to an aortic or iliac cause. CONCLUSIONS: In properly selected patients with complex anatomy, IBE can be used with nondedicated aortic and internal iliac components with good early term outcomes.


Assuntos
Implante de Prótese Vascular , Procedimentos Endovasculares , Aneurisma Ilíaco , Masculino , Humanos , Prótese Vascular , Implante de Prótese Vascular/efeitos adversos , Estudos Retrospectivos , Uso Off-Label , Resultado do Tratamento , Desenho de Prótese , Procedimentos Endovasculares/efeitos adversos , Fatores de Tempo , Stents , Aneurisma Ilíaco/diagnóstico por imagem , Aneurisma Ilíaco/cirurgia , Aneurisma Ilíaco/etiologia
2.
J Am Chem Soc ; 140(41): 13151-13155, 2018 10 17.
Artigo em Inglês | MEDLINE | ID: mdl-30281288

RESUMO

Ethylene is an important plant hormone that is involved in a variety of developmental processes including agriculturally important ripening of certain fruits. Owing to its significant roles, a number of approaches have previously been developed to detect ethylene via molecular interactions. However, there are no current approaches for detection that are selective via a discrete homogeneous molecular interaction. Here we report two profluorescent chemodosimeters for the selective detection of the plant hormone ethylene. The approach consists of a BODIPY fluorophore with a pendant ruthenium recognition element based on a Hoveyda-Grubbs second generation catalysts. A marked increase in fluorescence is observed upon exposure to ethylene and selectivity is observed for ethylene over other alkenes, providing a unique approach toward ethylene detection. Imaging in live cells demonstrated that ethylene could be detected from multiple relevant sources.


Assuntos
Compostos de Boro/química , Etilenos/análise , Corantes Fluorescentes/química , Compostos Organometálicos/química , Reguladores de Crescimento de Plantas/análise , Compostos de Boro/síntese química , Chlamydomonas reinhardtii , Etilenos/química , Corantes Fluorescentes/síntese química , Células HEK293 , Humanos , Hidrólise , Limite de Detecção , Mangifera/química , Microscopia Confocal/métodos , Microscopia de Fluorescência/métodos , Musa/química , Compostos Organometálicos/síntese química , Compostos Organofosforados/química , Reguladores de Crescimento de Plantas/química , Rutênio/química
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