Detalhe da pesquisa
1.
Efficacy and Pharmacodynamic Modeling of the BTK Inhibitor Evobrutinib in Autoimmune Disease Models.
J Immunol
; 202(10): 2888-2906, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30988116
2.
PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?
Nat Rev Immunol
; 7(3): 191-201, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17290298
3.
PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis.
Nat Cell Biol
; 9(1): 86-91, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17173040
4.
PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus.
Nat Med
; 11(9): 933-5, 2005 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16127435
5.
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.
Nat Med
; 11(9): 936-43, 2005 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16127437
6.
Functional whole-genome analysis identifies Polo-like kinase 2 and poliovirus receptor as essential for neuronal differentiation upstream of the negative regulator alphaB-crystallin.
J Biol Chem
; 284(46): 32053-65, 2009 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-19700763
7.
Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses.
Nat Rev Drug Discov
; 6(5): 391-403, 2007 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-17473844
8.
Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton's Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases.
J Med Chem
; 62(17): 7643-7655, 2019 09 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31368705
9.
Chemokine receptor CCR2 undergoes transportin1-dependent nuclear translocation.
Proteomics
; 8(21): 4560-76, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18846510
10.
Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma.
J Med Chem
; 49(13): 3857-71, 2006 Jun 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-16789742
11.
Isoform-selective phosphoinositide 3-kinase inhibitors induce apoptosis in chronic lymphocytic leukaemia cells.
Br J Haematol
; 150(1): 108-11, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20230409
12.
Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase.
J Med Chem
; 48(14): 4596-607, 2005 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-15999997
13.
Design, synthesis, and biological activity of novel, potent, and selective (benzoylaminomethyl)thiophene sulfonamide inhibitors of c-Jun-N-terminal kinase.
J Med Chem
; 47(27): 6921-34, 2004 Dec 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-15615541
14.
Modifications to the airway management trainer intubation head for training in difficult airway recognition through a comparative study with the Airsim® intubation head.
Simul Healthc
; 9(2): 136-40, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24614794
15.
ASK1 promotes the contact hypersensitivity response through IL-17 production.
Sci Rep
; 4: 4714, 2014 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-24736726
16.
Characterization of Novel PI3Kδ Inhibitors as Potential Therapeutics for SLE and Lupus Nephritis in Pre-Clinical Studies.
Front Immunol
; 5: 233, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24904582
17.
GLEPP1/protein-tyrosine phosphatase phi inhibitors block chemotaxis in vitro and in vivo and improve murine ulcerative colitis.
J Biol Chem
; 284(17): 11385-95, 2009 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-19233845
18.
BMP2 induction of actin cytoskeleton reorganization and cell migration requires PI3-kinase and Cdc42 activity.
J Cell Sci
; 121(Pt 23): 3960-70, 2008 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19001503
19.
Isoform-specific functions of phosphoinositide 3-kinases: p110 delta but not p110 gamma promotes optimal allergic responses in vivo.
J Immunol
; 180(4): 2538-44, 2008 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18250464
20.
The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion.
Blood
; 110(9): 3202-8, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17644738