Detalhe da pesquisa
1.
NNRTI-selected mutations at codon 190 of human immunodeficiency virus type 1 reverse transcriptase decrease susceptibility to stavudine and zidovudine.
Antiviral Res
; 76(2): 99-103, 2007 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17640745
2.
Parallel solution-phase and microwave-assisted synthesis of new S-DABO derivatives endowed with subnanomolar anti-HIV-1 activity.
J Med Chem
; 48(25): 8000-8, 2005 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16335924
3.
Classical dengue hemorrhagic fever resulting from two dengue infections spaced 20 years or more apart: Havana, Dengue 3 epidemic, 2001-2002.
Int J Infect Dis
; 9(5): 280-5, 2005 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16023878
4.
Vif is an auxiliary factor of the HIV-1 reverse transcriptase and facilitates abasic site bypass.
Biochem J
; 383(Pt. 3): 475-82, 2004 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15315477
5.
Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate.
Angew Chem Int Ed Engl
; 46(11): 1810-3, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17274083
6.
AKAP149 binds to HIV-1 reverse transcriptase and is involved in the reverse transcription.
J Mol Biol
; 383(4): 783-96, 2008 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-18786546
7.
Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the "primer grip" region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants.
Biochem Pharmacol
; 76(2): 156-68, 2008 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18541223
8.
Synthesis and biological investigation of S-aryl-S-DABO derivatives as HIV-1 inhibitors.
Bioorg Med Chem Lett
; 16(13): 3541-4, 2006 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16621553
9.
Arylthiopyrrole (AThP) derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis, structure-activity relationships, and docking studies (part 1).
ChemMedChem
; 1(12): 1367-78, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17089433
10.
Design, synthesis, biological evaluation, and molecular modeling studies of TIBO-like cyclic sulfones as non-nucleoside HIV-1 reverse transcriptase inhibitors.
ChemMedChem
; 1(1): 82-95, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16892340
11.
Drug resistance mutations in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase differentially affect the phosphorolysis-dependent primer unblocking activity in the presence of stavudine and zidovudine and its inhibition by efavirenz.
Antimicrob Agents Chemother
; 49(1): 342-9, 2005 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-15616314
12.
High potency of indolyl aryl sulfone nonnucleoside inhibitors towards drug-resistant human immunodeficiency virus type 1 reverse transcriptase mutants is due to selective targeting of different mechanistic forms of the enzyme.
Antimicrob Agents Chemother
; 49(11): 4546-54, 2005 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16251294
13.
Gln145Met/Leu changes in human immunodeficiency virus type 1 reverse transcriptase confer resistance to nucleoside and nonnucleoside analogs and impair virus replication.
Antimicrob Agents Chemother
; 48(12): 4611-7, 2004 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-15561833
14.
Effects of drug resistance mutations L100I and V106A on the binding of pyrrolobenzoxazepinone nonnucleoside inhibitors to the human immunodeficiency virus type 1 reverse transcriptase catalytic complex.
Antimicrob Agents Chemother
; 48(5): 1570-80, 2004 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15105107
15.
Role of the virology diagnosis laboratory in the surveillance of rubella virus Cuba 1988/2000.
Vaccine
; 22(31-32): 4287-90, 2004 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-15474720
16.
Dengue 3 epidemic, Havana, 2001.
Emerg Infect Dis
; 10(4): 719-22, 2004 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15200868
17.
N2-benzyloxycarbonylguan-9-yl acetic acid derivatives as HIV-1 reverse transcriptase non-nucleoside inhibitors with decreased loss of potency against common drug-resistance mutations.
ChemMedChem
; 2(10): 1405-9, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17638375
18.
Slow-, tight-binding HIV-1 reverse transcriptase non-nucleoside inhibitors highly active against drug-resistant mutants.
ChemMedChem
; 2(4): 445-8, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17323401
19.
Comparación de la línea NCI-H292 con otras líneas continuas para la multiplicación de virus respiratorios
Rev. cuba. med. trop
; 48(3): 171-173, sep.-dic. 1996.
Artigo
em Espanhol
| LILACS | ID: lil-629266
20.
Isolation and identification of Adenovirus in hospitalized children, under five years, with acute respiratory disease, in Havana, Cuba
Mem. Inst. Oswaldo Cruz
; 95(6): 859-61, Nov.-Dec. 2000. ilus, tab
Artigo
em Inglês
| LILACS | ID: lil-273441