Detalhe da pesquisa
1.
The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity.
Nature
; 575(7781): 217-223, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31666701
2.
RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer.
Genes Dev
; 31(20): 2099-2112, 2017 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29118048
3.
KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors.
N Engl J Med
; 383(13): 1207-1217, 2020 09 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32955176
4.
Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers.
Nat Cancer
; 5(1): 66-84, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38151625
5.
RANKL inhibition combined with tamoxifen treatment increases anti-tumor efficacy and prevents tumor-induced bone destruction in an estrogen receptor-positive breast cancer bone metastasis model.
Breast Cancer Res Treat
; 135(3): 771-80, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22926264
6.
Liver Metastasis Modulate Responses of Suppressive Macrophages and Exhausted T Cells to Immunotherapy Revealed by Single Cell Sequencing.
Adv Genet (Hoboken)
; 3(4): 2200002, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36911291
7.
Denosumab compared with zoledronic acid on PFS in multiple myeloma: exploratory results of an international phase 3 study.
Blood Adv
; 5(3): 725-736, 2021 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33560384
8.
AMG 757, a Half-Life Extended, DLL3-Targeted Bispecific T-Cell Engager, Shows High Potency and Sensitivity in Preclinical Models of Small-Cell Lung Cancer.
Clin Cancer Res
; 27(5): 1526-1537, 2021 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33203642
9.
Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors.
J Med Chem
; 63(1): 52-65, 2020 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31820981
10.
RANK ligand inhibition plus docetaxel improves survival and reduces tumor burden in a murine model of prostate cancer bone metastasis.
Mol Cancer Ther
; 7(7): 2160-9, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18606716
11.
Targeting Multiple Myeloma with AMG 424, a Novel Anti-CD38/CD3 Bispecific T-cell-recruiting Antibody Optimized for Cytotoxicity and Cytokine Release.
Clin Cancer Res
; 25(13): 3921-3933, 2019 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30918018
12.
Discovery of ( R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4- b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3 H)-one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological Malignancies.
J Med Chem
; 62(3): 1523-1540, 2019 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30624936
13.
Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis.
Clin Exp Metastasis
; 25(2): 119-29, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18064531
14.
Control of photoreceptor axon target choice by transcriptional repression of Runt.
Nat Neurosci
; 5(8): 746-50, 2002 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12118258
15.
AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.
Cancer Discov
; 8(12): 1582-1597, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30254093
16.
Radiosensitization of Adenoid Cystic Carcinoma with MDM2 Inhibition.
Clin Cancer Res
; 23(20): 6044-6053, 2017 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28659312
17.
Conserved microRNA characteristics in mammals.
Oligonucleotides
; 16(2): 115-44, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16764537
18.
Small Molecule Inhibition of MDM2-p53 Interaction Augments Radiation Response in Human Tumors.
Mol Cancer Ther
; 14(9): 1994-2003, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26162687
19.
The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents.
Mol Cancer Ther
; 14(3): 649-58, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25567130
20.
MDM2 antagonists synergize broadly and robustly with compounds targeting fundamental oncogenic signaling pathways.
Oncotarget
; 5(8): 2030-43, 2014 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-24810962