Detalhe da pesquisa
1.
A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation.
Nat Chem Biol
; 8(6): 576-82, 2012 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-22544264
2.
SAR studies around a series of triazolopyridines as potent and selective PI3Kγ inhibitors.
Bioorg Med Chem Lett
; 22(16): 5257-63, 2012 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22819766
3.
Novel Macrocyclic Antagonists of the CGRP Receptor Part 2: Stereochemical Inversion Induces an Unprecedented Binding Mode.
ACS Med Chem Lett
; 13(11): 1776-1782, 2022 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36385934
4.
Novel Macrocyclic Antagonists of the Calcitonin Gene-Related Peptide Receptor: Design, Realization, and Structural Characterization of Protein-Ligand Complexes.
ACS Chem Neurosci
; 13(6): 751-765, 2022 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35245037
5.
Structure-Based Drug Discovery of N-((R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(((S)-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2'-oxo-1',2'-dihydrospiro[piperidine-4,4'-pyrido[2,3-d][1,3]oxazine]-1-carboxamide (HTL22562): A Calcitonin Gene-Related Peptide Receptor Antagonist for Acute Treatment of Migraine.
J Med Chem
; 63(14): 7906-7920, 2020 07 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32558564
6.
CZ415, a Highly Selective mTOR Inhibitor Showing in Vivo Efficacy in a Collagen Induced Arthritis Model.
ACS Med Chem Lett
; 7(8): 768-73, 2016 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27563401
7.
Transient treatment with CDK inhibitors eliminates proliferative potential even when their abilities to evoke apoptosis and DNA damage are blocked.
Cell Cycle
; 7(24): 3898-907, 2008 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19066469
8.
Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR.
Bioorg Med Chem Lett
; 16(5): 1353-7, 2006 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16325401
9.
Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2.
Bioorg Med Chem Lett
; 15(4): 863-7, 2005 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15686876
10.
Structure-based design of peptidomimetic antagonists of p56(lck) SH2 domain.
Bioorg Med Chem Lett
; 12(10): 1365-9, 2002 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-11992778