Assuntos
Centros Médicos Acadêmicos , Dermatologia , Encaminhamento e Consulta , Humanos , Estudos Prospectivos , Centros Médicos Acadêmicos/estatística & dados numéricos , Encaminhamento e Consulta/estatística & dados numéricos , Criança , Feminino , Masculino , Pré-Escolar , Dermatopatias/diagnóstico , Dermatopatias/terapia , Lactente , Adolescente , PediatriaRESUMO
Radiation recall dermatitis (RRD) is an uncommon reaction typically triggered by the use of chemotherapeutic agents in the months after treatment with radiation therapy. It usually presents as dermatitis in the irradiated field with prominent intertriginous involvement, and because internal involvement occurs in up to one-third of cases, early recognition is important. RRD has rarely been reported in the pediatric literature. We report the case of a 15-month-old boy with RRD to dactinomycin.
Assuntos
Antibióticos Antineoplásicos/efeitos adversos , Dactinomicina/efeitos adversos , Radiodermite/diagnóstico , Humanos , Lactente , Neoplasias Renais/tratamento farmacológico , Neoplasias Renais/radioterapia , Masculino , Radiodermite/etiologia , Tumor Rabdoide/tratamento farmacológico , Tumor Rabdoide/radioterapiaRESUMO
OBJECTIVES: The objectives of the study were to determine the rate of hepatic hemangiomas in infants with cutaneous infantile hemangiomas that were screened by abdominal ultrasound; identify morphological subtypes and number of cutaneous infantile hemangiomas that are likely to suggest the presence of hepatic hemangiomas; and identify clinical history, physical findings, or laboratory abnormalities that may predict hepatic involvement. METHODS: A retrospective study was conducted between 2000 and 2007 on 37 infants with cutaneous hemangiomas who underwent abdominal ultrasound for hepatic hemangiomas. Infants were classified into subgroups based upon the morphology of their cutaneous hemangioma(s). Data collected included clinical history, physical examination findings, sonographic findings, laboratory results, treatment(s) rendered, and clinical outcome. RESULTS: Eight of 37 infants (22%) had hepatic hemangiomas. Infants with miliary (30-100 pinpoint/small cutaneous hemangiomas), six or more small cutaneous hemangiomas, and one large with one or more small cutaneous hemangiomas were more likely to have concurrent hepatic hemangiomas. No other clinical findings were associated with hepatic involvement. CONCLUSIONS: Similar to other studies, our study found clinically asymptomatic hepatic hemangiomas in 22% of infants with multiple cutaneous infantile hemangiomas. No clinical findings studied were predictive of hepatic involvement.
Assuntos
Hemangioma/epidemiologia , Neoplasias Hepáticas/epidemiologia , Neoplasias Primárias Múltiplas/epidemiologia , Neoplasias Cutâneas/epidemiologia , Feminino , Hemangioma/diagnóstico por imagem , Humanos , Lactente , Fígado/diagnóstico por imagem , Neoplasias Hepáticas/diagnóstico por imagem , Masculino , Estudos Retrospectivos , UltrassonografiaRESUMO
A 5-month-old boy with a previous history of failure to thrive and poor feeding was admitted to the hospital with failure to thrive, oral ulcers, and a generalized vesiculopustular rash that demonstrated a subcorneal pustule and neutrophilic infiltrate on histology. Esophagogastroduodenoscopy and flexible sigmoidoscopy biopsies demonstrated chronic active colitis with granulomas, consistent with the diagnosis of Crohn's disease. Our case represents, to our knowledge, the youngest person reported with this condition in association with Crohn's disease.