RESUMO
Parabiotic rat pairs with a skin-vascular anastomosis were used to test whether shielding of one member of the pair would protect the irradiated partner against exposure to very large doses of x-rays (1200 to 2400 roentgens). Except with the lowest dose, all unshielded, irradiated pairs or single irradiated animals died before 5 days had elapsed. In contrast, irradiated rats that had a shielded parabiont partner survived the 5-day period and many survived beyond 30 days. This is interpreted as protection against the acute intestinal death that normally occurs in the dose range investigated.
Assuntos
Parabiose , Lesões Experimentais por Radiação , Animais , Intestinos/efeitos da radiação , RatosRESUMO
This study was conducted to determine, on a prospective basis, the incidence of acute exertional rhabdomyolysis (AER) among recruits at the Marine Corps Recruit Depot, San Diego, Calif. Blood samples were taken from each of 337 volunteer recruits on each of their first six days of regularly scheduled training. Serum myoglobin, serum creatine phosphokinase, lactic dehydrogenase, and serum glutamic oxaloacetic transaminase values were used as indicators of muscle injury. Substantial elevations of serum enzyme activity were observed throughout the study population. Of the study population, 39.2% had serum myoglobin levels that ranged from 0.37 mug/ml to 21.9 mug/ml during the study interval. Six subjects had serum myoglobin levels consistent with those reported in clinical cases of AER. It is concluded that, in a recruit population, large numbers of men may have myoglobinemia but not be seen initially as clinical cases.
Assuntos
Medicina Militar , Mioglobinúria/epidemiologia , Esforço Físico , Doença Aguda , Aspartato Aminotransferases/sangue , Creatina Quinase/sangue , Humanos , L-Lactato Desidrogenase/sangue , Masculino , Mioglobina/sangue , Mioglobinúria/sangue , Mioglobinúria/enzimologia , Estados UnidosRESUMO
We have presented evidence that in an in vitro system, glycogenolysis and glycolysis function normally at potassium levels far below those observed in muscle cell water of severely deficient dogs. We suggest that a functional impairment of glycogenolysis or glycolysis is unlikely to be a mechanism by which potassium deficiency leads to rhabdomyolysis.