Detalhe da pesquisa
1.
Artificial intelligence-driven identification of morin analogues acting as CaV1.2 channel blockers: Synthesis and biological evaluation.
Bioorg Chem
; 131: 106326, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36563413
2.
Development of 1-(2-aminophenyl)pyrrole-based amides acting as human topoisomerase I inhibitors.
Arch Pharm (Weinheim)
; 356(10): e2300270, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37452410
3.
Pioneering first-in-class FAAH-HDAC inhibitors as potential multitarget neuroprotective agents.
Arch Pharm (Weinheim)
; 356(12): e2300410, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37750286
4.
Development of Quinazolinone Derivatives as Modulators of Virulence Factors of Pseudomonas aeruginosa Cystic Fibrosis Strains.
Molecules
; 28(18)2023 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37764311
5.
Novel Labdane Diterpenes-Based Synthetic Derivatives: Identification of a Bifunctional Vasodilator That Inhibits CaV1.2 and Stimulates KCa1.1 Channels.
Mar Drugs
; 20(8)2022 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36005518
6.
A Therapeutic Perspective of HDAC8 in Different Diseases: An Overview of Selective Inhibitors.
Int J Mol Sci
; 23(17)2022 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36077415
7.
FFAR1/GPR40: One target, different binding sites, many agonists, no drugs, but a continuous and unprofitable tug-of-war between ligand lipophilicity, activity, and toxicity.
Bioorg Med Chem Lett
; 41: 127969, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33771587
8.
Pinocembrin and its linolenoyl ester derivative induce wound healing activity in HaCaT cell line potentially involving a GPR120/FFA4 mediated pathway.
Bioorg Chem
; 108: 104657, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33556697
9.
Design, synthesis and pharmacological evaluation of ester-based quercetin derivatives as selective vascular KCa1.1 channel stimulators.
Bioorg Chem
; 105: 104404, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33142229
10.
Design, Synthesis and In Vitro Experimental Validation of Novel TRPV4 Antagonists Inspired by Labdane Diterpenes.
Mar Drugs
; 18(10)2020 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33081023
11.
Quercetin-3-oleoyl derivatives as new GPR40 agonists: Molecular docking studies and functional evaluation.
Bioorg Med Chem Lett
; 29(14): 1761-1764, 2019 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31104992
12.
Synthesis and anti-proliferative activity of a small library of 7-substituted 5H-pyrrole [1,2-a][3,1]benzoxazin-5-one derivatives.
Bioorg Med Chem Lett
; 27(14): 3092-3095, 2017 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28549734
13.
Metalloenzyme Inhibitors against Zoonotic Infections: Focus on Leishmania and Schistosoma.
ACS Infect Dis
; 10(5): 1520-1535, 2024 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38669567
14.
Synthetic derivatives of natural cinnamic acids as potential anti-colorectal cancer agents.
Chem Biol Drug Des
; 103(1): e14415, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38230797
15.
Traceability and authentication in agri-food production: A multivariate approach to the characterization ofthe Italian food excellence elephant garlic (Allium ampeloprasum L.), a vasoactive nutraceutical.
Food Chem
; 444: 138684, 2024 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38359701
16.
A novel potent class I HDAC inhibitor reverses the STAT4/p66Shc apoptotic defect in B cells from chronic lymphocytic leukemia patients.
Biomed Pharmacother
; 174: 116537, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38579402
17.
Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization.
J Med Chem
; 67(3): 1758-1782, 2024 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38241614
18.
Development of potent and selective FAAH inhibitors with improved drug-like properties as potential tools to treat neuroinflammatory conditions.
Eur J Med Chem
; 246: 114952, 2023 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36462439
19.
Nutritionally enriched tomatoes (Solanum lycopersicum L.) grown with wood distillate: chemical and biological characterization for quality assessment.
J Food Sci
; 88(12): 5324-5338, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37961008
20.
In Silico-Guided Rational Drug Design and Synthesis of Novel 4-(Thiophen-2-yl)butanamides as Potent and Selective TRPV1 Agonists.
J Med Chem
; 66(10): 6994-7015, 2023 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37192374