Detalhe da pesquisa
1.
Increasing serum half-life and extending cholesterol lowering in vivo by engineering antibody with pH-sensitive binding to PCSK9.
J Biol Chem
; 287(14): 11090-7, 2012 Mar 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-22294692
2.
RN765C, a low affinity EGFR antibody drug conjugate with potent anti-tumor activity in preclinical solid tumor models.
Oncotarget
; 9(71): 33446-33458, 2018 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30323890
3.
Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design.
Mol Cancer Ther
; 15(5): 958-70, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26944918
4.
Mechanism of action and in vivo efficacy of a human-derived antibody against Staphylococcus aureus α-hemolysin.
J Mol Biol
; 425(10): 1641-54, 2013 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-23416200
5.
Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates.
Chem Biol
; 20(2): 161-7, 2013 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23438745
6.
Generating bispecific human IgG1 and IgG2 antibodies from any antibody pair.
J Mol Biol
; 420(3): 204-19, 2012 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22543237
7.
Site-specific conjugation improves therapeutic index of antibody drug conjugates with high drug loading.
Nat Biotechnol
; 33(7): 694-6, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-26154005