Detalhe da pesquisa
1.
Leveraging the ATP-P2X7 receptor signalling axis to alleviate traumatic CNS damage and related complications.
Med Res Rev
; 43(5): 1346-1373, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36924449
2.
Tyrosine 288 in the extracellular domain of the human P2X7 receptor is critical for receptor function revealed by structural modeling and site-directed mutagenesis.
Proteins
; 90(3): 619-624, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34622987
3.
An Atypical Autoinflammatory Disease Due to an LRR Domain NLRP3 Mutation Enhancing Binding to NEK7.
J Clin Immunol
; 42(1): 158-170, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34671876
4.
Structural basis for the functional properties of the P2X7 receptor for extracellular ATP.
Purinergic Signal
; 17(3): 331-344, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33987781
5.
Inflammasome inhibition under physiological and pharmacological conditions.
Genes Immun
; 21(4): 211-223, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32681062
6.
Contribution of Val/Ile87 residue in the extracellular domain in agonist-induced current responses of the human and rat P2X7 receptors.
Purinergic Signal
; 16(4): 485-490, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33029714
7.
Conformational changes during human P2X7 receptor activation examined by structural modelling and cysteine-based cross-linking studies.
Purinergic Signal
; 13(1): 135-141, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28025718
8.
Docking of competitive inhibitors to the P2X7 receptor family reveals key differences responsible for changes in response between rat and human.
Bioorg Med Chem Lett
; 25(16): 3164-7, 2015 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26099538
9.
Non-synonymous single nucleotide polymorphisms in the P2X receptor genes: association with diseases, impact on receptor functions and potential use as diagnosis biomarkers.
Int J Mol Sci
; 15(8): 13344-71, 2014 Jul 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-25079442
10.
Drosophila expressing mutant human KCNT1 transgenes make an effective tool for targeted drug screening in a whole animal model of KCNT1-epilepsy.
Sci Rep
; 14(1): 3357, 2024 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38336906
11.
Inflammasome activation: from molecular mechanisms to autoinflammation.
Clin Transl Immunology
; 11(7): e1404, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35832835
12.
Moving towards a systems-based classification of innate immune-mediated diseases.
Nat Rev Rheumatol
; 16(4): 222-237, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32107482
13.
Biological Impact of Silicon Nitride for Orthopaedic Applications: Role of Particle Size, Surface Composition and Donor Variation.
Sci Rep
; 8(1): 9109, 2018 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29904079
14.
Structure-based identification and characterisation of structurally novel human P2X7 receptor antagonists.
Biochem Pharmacol
; 116: 130-9, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27481062