RESUMO
The studyFord AC, Wright-Hughes A, Alderson SL, et al. Amitriptyline at low-dose and titrated for irritable bowel syndrome as second-line treatment in primary care (ATLANTIS): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet 2023;402:1773-85.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/irritable-bowel-syndrome-low-dose-antidepressant-improves-symptoms/.
Assuntos
Amitriptilina , Síndrome do Intestino Irritável , Síndrome do Intestino Irritável/tratamento farmacológico , Humanos , Amitriptilina/administração & dosagem , Amitriptilina/uso terapêutico , Método Duplo-Cego , Antidepressivos/uso terapêutico , Antidepressivos/administração & dosagem , Ensaios Clínicos Controlados Aleatórios como Assunto , Antidepressivos Tricíclicos/administração & dosagem , Antidepressivos Tricíclicos/uso terapêutico , Resultado do Tratamento , Ensaios Clínicos Fase III como AssuntoRESUMO
The studyCarrie S, O'Hara J, Fouweather T, et al. Clinical effectiveness of septoplasty versus medical management for nasal airways obstruction: multicentre, open label, randomised controlled trial. BMJ 2023;383:e075445.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/surgery-is-better-than-nasal-sprays-for-people-with-severely-blocked-airways/.
Assuntos
Obstrução Nasal , Septo Nasal , Sprays Nasais , Humanos , Septo Nasal/cirurgia , Obstrução Nasal/cirurgia , Obstrução Nasal/etiologia , Rinoplastia/métodos , Resultado do Tratamento , Ensaios Clínicos Controlados Aleatórios como AssuntoRESUMO
The studyPavlova AV, Shim JSC, Moss R, et al. Effect of resistance exercise dose components for tendinopathy management: a systematic review with meta-analysis. Br J Sports Med 2023;57:1327-34.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/weights-resistance-bands-rest-days-best-tendinopathy/.
Assuntos
Terapia por Exercício , Doenças Musculoesqueléticas , Tendinopatia , Humanos , Doenças Musculoesqueléticas/terapia , Registros , Tendinopatia/terapia , Treinamento Resistido , DescansoRESUMO
The studyNeligan A, Adan G, Nevitt SJ, et al. Prognosis of adults and children following a first unprovoked seizure. Cochrane Database Syst Rev 2023;1:1-75.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/epilepsy-what-are-the-chances-of-having-a-second-seizure/.
Assuntos
Epilepsia , Convulsões , Criança , Adulto , Humanos , Convulsões/diagnóstico , Epilepsia/diagnóstico , PrognósticoRESUMO
The studySanter M, Muller I, Becque T. Eczema Care Online behavioural interventions to support self-care for children and young people: two independent, pragmatic, randomised controlled trials. BMJ 2022;379:e072007.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/online-support-improved-eczema-symptoms-in-children-and-young-people/.
Assuntos
Eczema , Humanos , Criança , Adolescente , Análise Custo-Benefício , Eczema/terapia , AutocuidadoRESUMO
The studyReeve J, Maden M, Hill R, et al. Deprescribing medicines in older people living with multimorbidity and polypharmacy: the TAILOR evidence synthesis. Health Technol Assess 2022;26:1-148.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/how-to-safely-deprescribe-medications-for-people-with-multiple-long-term-conditions/.
Assuntos
Desprescrições , Humanos , Idoso , MultimorbidadeRESUMO
The studyBrady MC, Ali M, VandenBerg K, et al. Complex speech-language therapy interventions for stroke-related aphasia: the RELEASE study incorporating a systematic review and individual participant data network meta-analysis. Health Social Care Delivery Res 2022;10.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/therapy-for-language-problems-after-a-stroke-is-most-effective-when-given-early-and-intensively/.
RESUMO
The studyKyrgiou M, Athanasiou A, Cieslak-Jones D. Comparative effectiveness and risk of preterm birth of local treatments for cervical intraepithelial neoplasia and stage IA1 cervical cancer: a systematic review and network meta-analysis. Lancet Oncol 2022;23:1097-108.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/prevention-of-cervical-cancer-what-are-the-risks-and-benefits-of-different-treatments/.
RESUMO
The studyBisson JI, Ariti C, Cullen K, et al. Guided, internet based, cognitive behavioural therapy for post-traumatic stress disorder: pragmatic, multicentre, randomised controlled non-inferiority trial (RAPID). BMJ 2022;377:e069405.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/online-cbt-for-ptsd-is-as-effective-as-face-to-face-therapy/.
Assuntos
Terapia Cognitivo-Comportamental , Transtornos de Estresse Pós-Traumáticos , Humanos , Transtornos de Estresse Pós-Traumáticos/terapia , Transtornos de Estresse Pós-Traumáticos/psicologia , Internet , Resultado do TratamentoRESUMO
The studyHarding C, Mossop H, Homer T, et al. Alternative to prophylactic antibiotics for the treatment of recurrent urinary tract infections in women: multicentre, open label, randomised, non-inferiority trial. BMJ 2022;376:e068229.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/methenamine-as-good-as-antibiotics-preventing-urinary-tract-infections/.
Assuntos
Metenamina , Infecções Urinárias , Feminino , Humanos , Antibacterianos/uso terapêutico , Infecções Urinárias/tratamento farmacológico , Infecções Urinárias/prevenção & controleRESUMO
The studyBlom AW, Lenguerrand, Strange S, et al. Clinical and cost effectiveness of single stage compared with two stage revision for hip prosthetic joint infection (INFORM): pragmatic, parallel group, open label, randomised controlled trial. BMJ 2022;379:e071281.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/one-stage-hip-revisions-are-as-good-as-2-stage-surgery-to-replace-infected-artificial-hips/.
Assuntos
Artroplastia de Quadril , Prótese de Quadril , Humanos , Artroplastia de Quadril/efeitos adversos , Articulação do Quadril/cirurgia , Prótese de Quadril/efeitos adversos , ReoperaçãoRESUMO
The studyHumphries ABC, Linsell L, Knight M. Factors associated with infection after operative vaginal birth-a secondary analysis of a randomized controlled trial of prophylactic antibiotics for the prevention of infection following operative vaginal birth. AJOG 2023;228:328.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/assisted-vaginal-births-women-need-prompt-antibiotics/.
Assuntos
Antibioticoprofilaxia , Parto , Infecção Puerperal , Humanos , Antibacterianos/uso terapêutico , Episiotomia/efeitos adversos , Lacerações , Infecção dos Ferimentos/tratamento farmacológico , Infecção dos Ferimentos/prevenção & controle , Feminino , Gravidez , Adulto , Parto Obstétrico , Infecção Puerperal/prevenção & controle , Infecção da Ferida Cirúrgica/prevenção & controleRESUMO
The studyConstable L, Abrams P, Cooper D, et. Synthetic sling or artificial urinary sphincter for men with urodynamic stress incontinence after prostate surgery: the MASTER non-inferiority RCT. Health Technol Assess 2022;26:1-152To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/male-sling-is-as-good-as-more-complex-surgery-for-incontinence-after-prostate-surgery/.
Assuntos
Slings Suburetrais , Incontinência Urinária por Estresse , Incontinência Urinária , Humanos , Masculino , Prostatectomia/efeitos adversos , Próstata , Incontinência Urinária/etiologia , Incontinência Urinária/cirurgia , Procedimentos Cirúrgicos Urológicos , Incontinência Urinária por Estresse/cirurgiaRESUMO
The studyKingsbury SR, Smith LK, Czoski Murray CJ, et al. Safety of disinvestment in mid- to late-term follow-up post primary hip and knee replacement: the UK SAFE evidence synthesis and recommendations. Health Soc Care Deliv Res 2022;10. doi:10.3310/KODQ0769To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/joint-replacement-many-people-can-safely-wait-10-years-for-follow-up/.
Assuntos
Artroplastia do Joelho , Humanos , Seguimentos , RegistrosRESUMO
OBJECTIVE: Examine neuroticism's impact on the relationship between depressive symptoms and sleep quality during the college transition. PARTICIPANTS: First-year students (N = 302) from a southeastern university in the USA. METHODS: A longitudinal cross-lagged panel model assessed direct and indirect effects between self-reported sleep and depressed mood. RESULTS: Higher neuroticism was directly associated with both greater depressed mood and sleep quality. Poorer sleep quality was associated with depressive symptoms at baseline (ß = 0.250, [95% CI = 0.123,0.362]) and during spring semester (ß = 0.261, [95% CI = 0.126,0.383]). Baseline depressive symptoms predicted sleep quality during fall semester (ß = 0.140, [95% CI = 0.031, 0.247]), and fall semester sleep quality predicted spring semester depression symptoms (ß = 0.106, [95% CI = 0.007,0.201]). DISCUSSION: Neuroticism is an indicator of emotional distress and disrupted sleep upon college entry. Furthermore, there was evidence for both within time-point and prospective associations between sleep quality and depression symptoms albeit at different times throughout the first year of college.
Assuntos
Depressão , Qualidade do Sono , Humanos , Depressão/psicologia , Universidades , Neuroticismo , Estudantes/psicologia , SonoRESUMO
The studyThe Blood Pressure Lowering Treatment Trialists' Collaboration. Age-stratified and blood-pressure-stratified effects of blood-pressure-lowering pharmacotherapy for the prevention of cardiovascular disease and death: an individual participant-level data meta-analysis. Lancet 2021;398:1053-64.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/people-of-all-ages-benefit-from-drugs-to-lower-blood-pressure/.
Assuntos
Doenças Cardiovasculares , Hipertensão , Anti-Hipertensivos/farmacologia , Anti-Hipertensivos/uso terapêutico , Pressão Sanguínea , Doenças Cardiovasculares/tratamento farmacológico , Doenças Cardiovasculares/prevenção & controle , Humanos , Hipertensão/tratamento farmacológico , Metanálise como Assunto , Sinais VitaisRESUMO
The studyDrake TM, Riad AM, Fairfield CJ, et al. Characterisation of in-hospital complications associated with covid-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study. Lancet 2021;398:10296.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/one-in-two-people-hospitalised-with-covid-19-develop-complications-may-need-support/.
Assuntos
COVID-19 , COVID-19/complicações , Estudos de Coortes , Hospitalização , Hospitais , Humanos , Estudos ProspectivosRESUMO
The studySharpe D, Rajabi M, Harden A, et al. Supporting disengaged children and young people living with diabetes to self-care: a qualitative study in a socially disadvantaged and ethnically diverse urban area. BMJ Open 2021;11:e046989.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/why-dont-young-people-engage-with-diabetes-services/.
Assuntos
Diabetes Mellitus , Adolescente , Criança , Diabetes Mellitus/terapia , Humanos , Pesquisa Qualitativa , AutocuidadoRESUMO
The studyVinogradova Y, Coupland C, Hippisley-Cox J. Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases. BMJ 2020;371:m3873. To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/risk-of-breast-cancer-with-hrt-depends-therapy-type-and-duration/.
Assuntos
Neoplasias da Mama/induzido quimicamente , Terapia de Reposição de Estrogênios/efeitos adversos , Terapia de Reposição de Estrogênios/métodos , Estrogênios/efeitos adversos , Progestinas/efeitos adversos , Fatores Etários , Idoso , Estudos de Casos e Controles , Didrogesterona/administração & dosagem , Didrogesterona/efeitos adversos , Estrogênios/administração & dosagem , Feminino , Humanos , Pessoa de Meia-Idade , Noretindrona/administração & dosagem , Noretindrona/efeitos adversos , Progestinas/administração & dosagem , Fatores de Risco , Fatores de TempoRESUMO
The studyCrossingham I, Turner S, Ramakrishnan S, et al. Combination fixed-dose ß agonist and steroid inhaler as required for adults or children with mild asthma: a Cochrane systematic review. BMJ Evid Based Med 2021; doi:10.1136/bmjebm-2021-111764To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/combination-inhaler-is-effective-in-mild-asthma/.