Detalhe da pesquisa
1.
Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer's Disease.
Molecules
; 25(14)2020 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32664425
2.
Astrocyte-induced synaptogenesis is mediated by transforming growth factor ß signaling through modulation of D-serine levels in cerebral cortex neurons.
J Biol Chem
; 287(49): 41432-45, 2012 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-23055518
3.
P2X7 Receptor Triggers Lysosomal Leakage Through Calcium Mobilization in a Mechanism Dependent on Pannexin-1 Hemichannels.
Front Immunol
; 13: 752105, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35222364
4.
Effects of combined 5-HT2A and cannabinoid receptor modulation on a schizophrenia-related prepulse inhibition deficit in mice.
Psychopharmacology (Berl)
; 237(6): 1643-1655, 2020 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-32095916
5.
Novel 6-methanesulfonamide-3,4-methylenedioxyphenyl-N-acylhydrazones: orally effective anti-inflammatory drug candidates.
Bioorg Med Chem
; 17(3): 1125-31, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19135376
6.
Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice.
Nat Commun
; 10(1): 3890, 2019 09 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31488835
7.
CNS-selective noncompetitive cholinesterase inhibitors derived from the natural piperidine alkaloid (-)-spectaline.
Eur J Pharmacol
; 580(3): 339-49, 2008 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-18096154
8.
Generation of iPSC-Derived Human Peripheral Sensory Neurons Releasing Substance P Elicited by TRPV1 Agonists.
Front Mol Neurosci
; 11: 277, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30186108
9.
Dopamine promotes NMDA receptor hypofunction in the retina through D1 receptor-mediated Csk activation, Src inhibition and decrease of GluN2B phosphorylation.
Sci Rep
; 7: 40912, 2017 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28098256
10.
Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease.
Eur J Med Chem
; 130: 440-457, 2017 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28282613
11.
Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease.
Eur J Med Chem
; 108: 687-700, 2016 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-26735910
12.
Mitomycin-treated undifferentiated embryonic stem cells as a safe and effective therapeutic strategy in a mouse model of Parkinson's disease.
Front Cell Neurosci
; 9: 97, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25904842
13.
Design, synthesis, and pharmacological profile of novel fused pyrazolo[4,3-d]pyridine and pyrazolo[3,4-b][1,8]naphthyridine isosteres: a new class of potent and selective acetylcholinesterase inhibitors.
J Med Chem
; 46(7): 1144-52, 2003 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-12646025
14.
Characterization of a new synthetic isoflavonoid with inverse agonist activity at the central benzodiazepine receptor.
Eur J Pharmacol
; 495(2-3): 87-96, 2004 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-15249156
15.
Spine density and dendritic branching pattern of hippocampal CA1 pyramidal neurons in neonatal rats chronically exposed to the organophosphate paraoxon.
Neurotoxicology
; 25(3): 481-94, 2004 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15019311
16.
Erythrina mulungu alkaloids are potent inhibitors of neuronal nicotinic receptor currents in mammalian cells.
PLoS One
; 8(12): e82726, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24349349
17.
Geissospermum vellosii stembark: anticholinesterase activity and improvement of scopolamine-induced memory deficits.
Pharmacol Biochem Behav
; 92(3): 508-13, 2009 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19463267
18.
The magnitude of alpha7 nicotinic receptor currents in rat hippocampal neurons is dependent upon GABAergic activity and depolarization.
J Pharmacol Exp Ther
; 319(1): 376-85, 2006 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16837558
19.
New selective acetylcholinesterase inhibitors designed from natural piperidine alkaloids.
Bioorg Med Chem
; 13(13): 4184-90, 2005 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15878668
20.
Low concentrations of pyridostigmine prevent soman-induced inhibition of GABAergic transmission in the central nervous system: involvement of muscarinic receptors.
J Pharmacol Exp Ther
; 304(1): 254-65, 2003 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-12490599