Detalhe da pesquisa
1.
Phenotypic screening of the ReFRAME drug repurposing library to discover new drugs for treating sickle cell disease.
Proc Natl Acad Sci U S A
; 119(40): e2210779119, 2022 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36161945
2.
Functional and multi-omics signatures of mitapivat efficacy upon activation of pyruvate kinase in red blood cells from patients with sickle cell disease.
Haematologica
; 2024 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38450513
3.
Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin.
Blood
; 138(13): 1172-1181, 2021 09 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34197597
4.
Allosteric control of hemoglobin S fiber formation by oxygen and its relation to the pathophysiology of sickle cell disease.
Proc Natl Acad Sci U S A
; 117(26): 15018-15027, 2020 06 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32527859
5.
Kinetic assay shows that increasing red cell volume could be a treatment for sickle cell disease.
Proc Natl Acad Sci U S A
; 114(5): E689-E696, 2017 01 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-28096387
6.
Making connections between ultrafast protein folding kinetics and molecular dynamics simulations.
Proc Natl Acad Sci U S A
; 108(15): 6103-8, 2011 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-21441105
7.
In vivo measurement of RBC survival in patients with sickle cell disease before or after hematopoietic stem cell transplantation.
Blood Adv
; 8(7): 1806-1816, 2024 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38181784
8.
Measuring ultrafast protein folding rates from photon-by-photon analysis of single molecule fluorescence trajectories.
Chem Phys
; 422: 229-237, 2013 Aug 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-24443626
9.
Extracting rate coefficients from single-molecule photon trajectories and FRET efficiency histograms for a fast-folding protein.
J Phys Chem A
; 115(16): 3642-56, 2011 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-20509636
10.
Measuring internal friction of an ultrafast-folding protein.
Proc Natl Acad Sci U S A
; 105(47): 18320-5, 2008 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-19020085
11.
Chemical, physical, and theoretical kinetics of an ultrafast folding protein.
Proc Natl Acad Sci U S A
; 105(48): 18655-62, 2008 Dec 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-19033473
12.
Theoretical Simulation of Red Cell Sickling Upon Deoxygenation Based on the Physical Chemistry of Sickle Hemoglobin Fiber Formation.
J Phys Chem B
; 122(49): 11579-11590, 2018 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30179501
13.
Dynamics of Structural Elements of GB1 ß-Hairpin Revealed by Tryptophan-Cysteine Contact Formation Experiments.
J Phys Chem B
; 122(49): 11468-11477, 2018 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30215522
14.
Protein aggregation in silico.
Trends Biotechnol
; 25(6): 254-61, 2007 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-17433843
15.
Relaxation rate for an ultrafast folding protein is independent of chemical denaturant concentration.
J Am Chem Soc
; 129(47): 14564-5, 2007 Nov 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17983235
16.
Kinetic studies of protein L aggregation and disaggregation.
Biophys Chem
; 125(2-3): 350-9, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17055144
17.
Universality of supersaturation in protein-fiber formation.
Nat Struct Mol Biol
; 23(5): 459-61, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27018803
18.
Coarse-grained simulations of protein aggregation.
Methods Mol Biol
; 899: 453-70, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22735969
19.
Evidence of multiple folding pathways for the villin headpiece subdomain.
J Phys Chem B
; 115(43): 12632-7, 2011 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-21923150
20.
Molecular simulation of protein aggregation.
Biotechnol Bioeng
; 96(1): 1-8, 2007 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17136749