RESUMO
An efficient electrochemical trifluoromethylation of coumarins using CF3SO2NHNHBoc as the source of the trifluoromethyl group was developed. Under catalyst-free and external oxidant-free electrolysis conditions, a range of 3-trifluoromethyl coumarins were obtained in moderate to good yields. The method could be easily scaled up with moderate efficiency.
RESUMO
To meet the rapidly growing and diversified demand for energy storage, advanced rechargeable batteries with high-performance materials and efficient battery configuration are widely being exploited and developed. Bipolar-stacked electrode coupling with solid-state electrolytes enables achieving batteries with high output voltage, high energy density, and simple components. Here, a polymer electrolyte membrane is designed with polyethylene oxide containing bis(trifluoromethanesulfonyl)-imide as the electrolyte, succinonitrile as the plasticizer, and nylon mesh as a reinforcement for the bipolar-stacked battery. The as-prepared nylon mesh-reinforced polymer electrolyte membrane shows advantageous features, that is, excellent ionic conductivity (3.38 × 10-4 S cm-1) at room temperature, low interface impedance, and good tolerance against the expansion caused by the plating/stripping of the Li anode and the electrode upon cycling. When used as a polymer electrolyte membrane in the bipolar-stacked battery, the LiFePO4(LFP)-Li4Ti5O12(LTO) cell with three cells connected in series delivers a higher discharge voltage (5.4 V) and a volumetric energy density (0.328 mW h cm-3), nearly 3 times as much as that of the LFP-LTO battery. In addition, LiFePO4-Li pouch cells using the polymer electrolyte membrane can sustain the abuse tests including bending, cutting, and nail penetration well. These results pave a new avenue to develop high-performance polymer electrolyte membranes and allow for the design of high-voltage and volumetric energy density bipolar-stacked batteries.
RESUMO
The aim of the present study was to examine the pharmacokinetics of a single intravenous injection (i.v.) and oral administration (p.o.) of diclofenac sodium (DIC) in Sprague-Dawley (SD) rats. Twelve male SD rats were divided into 2 groups (n=6 per group); one group was injected intravenously with 2 mg/kg DIC, whereas the other group was lavaged with 2 mg/kg DIC. Blood samples were collected prior to DIC delivery (0 h) and 0.033, 0.083, 0.167, 0.25, 0.5, 1, 2, 4, 6, and 8 h post-administration. Blood plasma samples were analyzed using liquid chromatography-mass spectrometry (LC-MS/MS) following pretreatment to induce protein precipitation. Pharmacokinetics software was applied to calculate relevant pharmacokinetic parameters using a non-compartmental model. Following i.v. administration of DIC, the terminal elimination rate constant (λz), apparent terminal elimination half-life (t½), area under the concentration-time curve from time 0 extrapolated to infinity (AUC0-∞), clearance (CL), apparent volume of distribution (Vz), mean residence time (MRT), and apparent volume of distribution at steady state (Vss) were 0.57±0.05 l/h, 1.22±0.11 h, 3356±238 h × ng/ml, 0.60±0.04 l/h, 1.05±0.10 l, 1.05±0.07 h and 0.63±0.07 l, respectively. Following p.o. administration of DIC, the λz, t½, Cmax, tmax, AUC0-∞, CL, Vz, MRT were: 0.63±0.12 l/h, 1.12±0.18 h, 1272±112 ng/ml, 0.19±0.04 h, 2501±303 h × ng/ml, 0.81±0.10 l/h, 1.29±0.12 l, and 2.70±0.18 h, respectively. The pharmacokinetic parameters of i.v. and p.o. DIC in rats show that the drug is rapidly absorbed, distributed, and eliminated.