Detalhe da pesquisa
1.
Domino synthesis of 5-aminoimidazoles from Strecker multicomponent adducts via ytterbium-promoted isocyanide insertion/5-exo-dig cyclization.
Mol Divers
; 27(1): 511-515, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-35416620
2.
Turning a Tumor Microenvironment Pitfall into Opportunity: Discovery of Benzamidoxime as PD-L1 Ligand with pH-Dependent Potency.
Int J Mol Sci
; 24(6)2023 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36982608
3.
Multi-Gram Scale Synthesis and Characterization of Mometasone Furoate EP Impurity C.
Molecules
; 28(23)2023 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38067588
4.
Enantioselective HPLC Analysis to Assist the Chemical Exploration of Chiral Imidazolines.
Molecules
; 25(3)2020 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32024219
5.
Optimisation by Design of Experiment of Benzimidazol-2-One Synthesis under Flow Conditions.
Molecules
; 24(13)2019 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31277341
6.
Steroids interfere with human carbonic anhydrase activity by using alternative binding mechanisms.
J Enzyme Inhib Med Chem
; 33(1): 1453-1459, 2018 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-30221552
7.
Selected cholesterol biosynthesis inhibitors produce accumulation of the intermediate FF-MAS that targets nucleus and activates LXRα in HepG2 cells.
Biochim Biophys Acta Mol Cell Biol Lipids
; 1862(9): 842-852, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28499814
8.
Patented Farnesoid X receptor modulators: a review (2019 - present).
Expert Opin Ther Pat
; : 1-18, 2024 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38308658
9.
Chemical exploration of TGR5 functional hot-spots: Synthesis and structure-activity relationships of C7- and C23-Substituted cholic acid derivatives.
Eur J Med Chem
; 261: 115851, 2023 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37813065
10.
Development of 3α,7α-dihydroxy-6α-ethyl-24-nor-5ß-cholan-23-sulfate sodium salt (INT-767): Process optimization, synthesis and characterization of metabolites.
Eur J Med Chem
; 242: 114652, 2022 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36049273
11.
The Stone Guest: How Does pH Affect Binding Properties of PD-1/PD-L1 Inhibitors?
ChemMedChem
; 16(3): 568-577, 2021 02 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33085193
12.
The Medicinal Chemistry in the Era of Machines and Automation: Recent Advances in Continuous Flow Technology.
J Med Chem
; 63(13): 6624-6647, 2020 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32049517
13.
Integrating experimental and computational techniques to study chromatographic enantioresolutions of chiral tetrahydroindazole derivatives.
J Chromatogr A
; 1625: 461310, 2020 Aug 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32709352
14.
Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor.
J Med Chem
; 63(7): 3701-3712, 2020 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32160459
15.
Exploiting Chemical Toolboxes for the Expedited Generation of Tetracyclic Quinolines as a Novel Class of PXR Agonists.
ACS Med Chem Lett
; 10(4): 677-681, 2019 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30996817
16.
Synthesis, physicochemical properties, and biological activity of bile acids 3-glucuronides: Novel insights into bile acid signalling and detoxification.
Eur J Med Chem
; 144: 349-358, 2018 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-29275233
17.
Binding Mode and Structure-Activity Relationships of ITE as an Aryl Hydrocarbon Receptor (AhR) Agonist.
ChemMedChem
; 13(3): 270-279, 2018 02 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29266750
18.
Bile acid derivatives as ligands of the farnesoid x receptor: molecular determinants for bile acid binding and receptor modulation.
Curr Top Med Chem
; 14(19): 2159-74, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25388535
19.
Beyond bile acids: targeting Farnesoid X Receptor (FXR) with natural and synthetic ligands.
Curr Top Med Chem
; 14(19): 2129-42, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25388537
20.
Synthesis of atypical bile acids for use as investigative tools for the genetic defect of 3ß-hydroxy-Δ(5)-C27-steroid oxidoreductase deficiency.
J Steroid Biochem Mol Biol
; 144 Pt B: 348-60, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24954360