1.
Org Biomol Chem
; 15(18): 3985-3994, 2017 May 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28443880
RESUMO
The first asymmetric synthesis of ent-fragransin C1 was reported. The key step involves an intramolecular C-O bond formation (furan ring formation) via chemoselective generation of the benzylic carbocation leading to the 2,3-anti-3,4-syn-4,5-anti-tetrahydrofuran moiety as a single diastereomer in good yield. Our synthesis confirms that ent-fragransin C1 possesses 2R,3R,4S,5S configurations.