Detalhe da pesquisa
1.
Exploring CRD mobility during RAS/RAF engagement at the membrane.
Biophys J
; 121(19): 3630-3650, 2022 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35778842
2.
Covalent inhibitors for eradication of drug-resistant HIV-1 reverse transcriptase: From design to protein crystallography.
Proc Natl Acad Sci U S A
; 114(36): 9725-9730, 2017 09 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28827354
3.
Post-Catalytic Complexes with Emtricitabine or Stavudine and HIV-1 Reverse Transcriptase Reveal New Mechanistic Insights for Nucleotide Incorporation and Drug Resistance.
Molecules
; 25(20)2020 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33096918
4.
Structural and Preclinical Studies of Computationally Designed Non-Nucleoside Reverse Transcriptase Inhibitors for Treating HIV infection.
Mol Pharmacol
; 91(4): 383-391, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28167742
5.
Structure of the Bacillus anthracis Sortase A Enzyme Bound to Its Sorting Signal: A FLEXIBLE AMINO-TERMINAL APPENDAGE MODULATES SUBSTRATE ACCESS.
J Biol Chem
; 290(42): 25461-74, 2015 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26324714
6.
Discovery and crystallography of bicyclic arylaminoazines as potent inhibitors of HIV-1 reverse transcriptase.
Bioorg Med Chem Lett
; 25(21): 4824-4827, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26166629
7.
Crystallographic Studies of KRAS in Complex with Small Molecules and RAS-Binding Proteins.
Methods Mol Biol
; 2797: 47-65, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38570452
8.
Reduced dynamic complexity allows structure elucidation of an excited state of KRASG13D.
Commun Biol
; 6(1): 594, 2023 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37268708
9.
Exploring novel HIV-1 reverse transcriptase inhibitors with drug-resistant mutants: A double mutant surprise.
Protein Sci
; 32(12): e4814, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37861472
10.
Structural Studies and Structure Activity Relationships for Novel Computationally Designed Non-nucleoside Inhibitors and Their Interactions With HIV-1 Reverse Transcriptase.
Front Mol Biosci
; 9: 805187, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35237658
11.
Asynchronous Reciprocal Coupling of Martini 2.2 Coarse-Grained and CHARMM36 All-Atom Simulations in an Automated Multiscale Framework.
J Chem Theory Comput
; 18(8): 5025-5045, 2022 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35866871
12.
KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.
Nat Commun
; 12(1): 1176, 2021 02 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33608534
13.
Structural investigation of 2-naphthyl phenyl ether inhibitors bound to WT and Y181C reverse transcriptase highlights key features of the NNRTI binding site.
Protein Sci
; 29(9): 1902-1910, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32643196
14.
Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine.
Protein Sci
; 28(9): 1664-1675, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31301259
15.
Structural and pharmacological evaluation of a novel non-nucleoside reverse transcriptase inhibitor as a promising long acting nanoformulation for treating HIV.
Antiviral Res
; 167: 110-116, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31034849
16.
NMR structure-based optimization of Staphylococcus aureus sortase A pyridazinone inhibitors.
Chem Biol Drug Des
; 90(3): 327-344, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28160417
17.
Design, Conformation, and Crystallography of 2-Naphthyl Phenyl Ethers as Potent Anti-HIV Agents.
ACS Med Chem Lett
; 7(12): 1156-1160, 2016 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27994756
18.
Crystal Structure of the Streptomyces coelicolor Sortase E1 Transpeptidase Provides Insight into the Binding Mode of the Novel Class E Sorting Signal.
PLoS One
; 11(12): e0167763, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27936128
19.
The PRE-Derived NMR Model of the 38.8-kDa Tri-Domain IsdH Protein from Staphylococcus aureus Suggests That It Adaptively Recognizes Human Hemoglobin.
J Mol Biol
; 428(6): 1107-1129, 2016 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-25687963
20.
Bodyweight assessment of enamelin null mice.
Biomed Res Int
; 2013: 246861, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23509695