Detalhe da pesquisa
1.
Discovery and preclinical evaluations of TQB3616, a novel CDK4-biased inhibitor.
Bioorg Med Chem Lett
; 107: 129769, 2024 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38670537
2.
Discovery and preclinical profile of LX-039, a novel indole-based oral selective estrogen receptor degrader (SERD).
Bioorg Med Chem Lett
; 66: 128734, 2022 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35436589
3.
Design, syntheses and evaluations of novel indole derivatives as orally selective estrogen receptor degraders (SERD).
Bioorg Med Chem Lett
; 30(22): 127601, 2020 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33035677
4.
Oral arsenic trioxide incorporation into frontline treatment with all-trans retinoic acid and chemotherapy in newly diagnosed acute promyelocytic leukemia: A 5-year prospective study.
Cancer
; 125(17): 3001-3012, 2019 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31090936
5.
Exploring the Potential of RET Kinase Inhibition for Irritable Bowel Syndrome: A Preclinical Investigation in Rodent Models of Colonic Hypersensitivity.
J Pharmacol Exp Ther
; 368(2): 299-307, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30413627
6.
Genetic association between germline JAK2 polymorphisms and myeloproliferative neoplasms in Hong Kong Chinese population: a case-control study.
BMC Genet
; 15: 147, 2014 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25526816
7.
Clinical characteristics of COVID-19 patients infected by the Omicron variants in Macao, China: A cross-sectional study.
Health Sci Rep
; 6(7): e1361, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37404450
8.
Plasma-based approach to measure target engagement for liver-targeting stearoyl-CoA desaturase 1 inhibitors.
J Lipid Res
; 52(8): 1494-9, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21642745
9.
Biological activity and preclinical efficacy of azetidinyl pyridazines as potent systemically-distributed stearoyl-CoA desaturase inhibitors.
Bioorg Med Chem Lett
; 21(1): 479-83, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21074991
10.
Nicotinic acids: liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy.
Bioorg Med Chem Lett
; 21(24): 7281-6, 2011 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22047692
11.
Synthesis and SAR of pyrimidine-based, non-nucleotide P2Y14 receptor antagonists.
Bioorg Med Chem Lett
; 21(10): 2832-5, 2011 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21507642
12.
SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors.
Bioorg Med Chem Lett
; 20(5): 1593-7, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20137926
13.
Clofarabine, cytarabine, and mitoxantrone in refractory/relapsed acute myeloid leukemia: High response rates and effective bridge to allogeneic hematopoietic stem cell transplantation.
Cancer Med
; 9(10): 3371-3382, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32187883
14.
Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor.
Bioorg Med Chem Lett
; 18(11): 3200-5, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18477508
15.
Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein.
Bioorg Med Chem Lett
; 18(6): 2023-7, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18276139
16.
Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis.
J Clin Invest
; 110(7): 1045-52, 2002 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-12370283
17.
Pharmacological characterization of a selective COX-2 inhibitor MF-tricyclic, [3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone], in multiple preclinical species.
Eur J Pharmacol
; 560(2-3): 216-24, 2007 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-17316604
18.
Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9.
Diabetes
; 54(10): 2988-94, 2005 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16186403
19.
Preferential inhibition of human phosphodiesterase 4 by ibudilast.
Life Sci
; 78(23): 2663-8, 2006 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16313925
20.
Long-term outcome of 231 patients with essential thrombocythemia: prognostic factors for thrombosis, bleeding, myelofibrosis, and leukemia.
Arch Intern Med
; 165(22): 2651-8, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-16344424