Detalhe da pesquisa
1.
A tryptophan metabolite made by a gut microbiome eukaryote induces pro-inflammatory T cells.
EMBO J
; 42(21): e112963, 2023 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37743772
2.
Plasma fatty acid esters of hydroxy fatty acids and surrogate fatty acid esters of hydroxy fatty acids hydrolysis activity in children with or without obesity and in adults with or without coronary artery disease.
Diabetes Obes Metab
; 2024 May 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38812281
3.
Physiologically-based pharmacokinetic modelling guided dose evaluations of nirmatrelvir/ritonavir in renal impairment for the management of COVID-19.
Br J Clin Pharmacol
; 2024 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38616514
4.
Probe Substrate Dependencies in CYP3A4 Allosteric Inhibition: A Novel Molecular Mechanism Involving F-F' Loop Perturbations.
J Chem Inf Model
; 64(6): 2058-2067, 2024 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38457234
5.
In silico identification of novel ACE and DPP-IV inhibitory peptides derived from buffalo milk proteins and evaluation of their inhibitory mechanisms.
Amino Acids
; 55(2): 161-171, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-36701004
6.
Development and verification of a physiologically based pharmacokinetic model of dronedarone and its active metabolite N-desbutyldronedarone: Application to prospective simulation of complex drug-drug interaction with rivaroxaban.
Br J Clin Pharmacol
; 89(6): 1873-1890, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36683488
7.
Mechanistic Middle-Out Physiologically Based Toxicokinetic Modeling of Transporter-Dependent Disposition of Perfluorooctanoic Acid in Humans.
Environ Sci Technol
; 57(17): 6825-6834, 2023 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37072124
8.
Model-Based Risk Prediction of Rivaroxaban with Amiodarone for Moderate Renal Impaired Elderly Population.
Cardiovasc Drugs Ther
; 37(3): 605-609, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34705149
9.
Simvastatin, but Not Atorvastatin, Is Associated with Higher Peak Rivaroxaban Serum Levels and Bleeding: an Asian Cohort Study from Singapore.
Cardiovasc Drugs Ther
; 37(5): 917-925, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35567727
10.
Experimental colonization with Blastocystis ST4 is associated with protective immune responses and modulation of gut microbiome in a DSS-induced colitis mouse model.
Cell Mol Life Sci
; 79(5): 245, 2022 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35435504
11.
Lactobacillus paracasei IMC 502 ameliorates type 2 diabetes by mediating gut microbiota-SCFA-hormone/inflammation pathway in mice.
J Sci Food Agric
; 103(6): 2949-2959, 2023 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-36221226
12.
Identification of Infigratinib as a Potent Reversible Inhibitor and Mechanism-Based Inactivator of CYP2J2: Nascent Evidence for a Potential In Vivo Metabolic Drug-Drug Interaction with Rivaroxaban.
J Pharmacol Exp Ther
; 382(2): 123-134, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35640957
13.
Identification of Optimal Urinary Biomarkers of Synthetic Cannabinoids BZO-HEXOXIZID, BZO-POXIZID, 5F-BZO-POXIZID, and BZO-CHMOXIZID for Illicit Abuse Monitoring.
Clin Chem
; 68(11): 1436-1448, 2022 11 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36175111
14.
Metabolic Activation of the Acrylamide Michael Acceptor Warhead in Futibatinib to an Epoxide Intermediate Engenders Covalent Inactivation of CYP3A.
Drug Metab Dispos
; 50(7): 931-941, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35512804
15.
Direct and Sequential Bioactivation of Pemigatinib to Reactive Iminium Ion Intermediates Culminates in Mechanism-Based Inactivation of Cytochrome P450 3A.
Drug Metab Dispos
; 50(5): 529-540, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35153194
16.
Application of a physiologically based pharmacokinetic model of rivaroxaban to prospective simulations of drug-drug-disease interactions with protein kinase inhibitors in cancer-associated venous thromboembolism.
Br J Clin Pharmacol
; 88(5): 2267-2283, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34837258
17.
Febuxostat and its major acyl glucuronide metabolite are potent inhibitors of organic anion transporter 3: Implications for drug-drug interactions with rivaroxaban.
Biopharm Drug Dispos
; 43(2): 57-65, 2022 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-35088420
18.
Mechanism-Based Inactivation of Cytochrome P450 3A4 by Benzbromarone.
Mol Pharmacol
; 99(4): 266-276, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33436520
19.
Differential Reversible and Irreversible Interactions between Benzbromarone and Human Cytochrome P450s 3A4 and 3A5.
Mol Pharmacol
; 100(3): 224-236, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34210765
20.
Urinary Metabolite Biomarkers for the Detection of Synthetic Cannabinoid ADB-BUTINACA Abuse.
Clin Chem
; 67(11): 1534-1544, 2021 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34387654