Detalhe da pesquisa
1.
Comparative assessment of viral dynamic models for SARS-CoV-2 for pharmacodynamic assessment in early treatment trials.
Br J Clin Pharmacol
; 88(12): 5428-5433, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36040430
2.
Patient Centric Microsampling to Support Paxlovid Clinical Development: Bridging and Implementation.
Clin Pharmacol Ther
; 115(1): 42-51, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37597239
3.
A Comprehensive Review of the Clinical Pharmacokinetics, Pharmacodynamics, and Drug Interactions of Nirmatrelvir/Ritonavir.
Clin Pharmacokinet
; 63(1): 27-42, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38177893
4.
Dosing recommendation of nirmatrelvir/ritonavir using an integrated population pharmacokinetic analysis.
CPT Pharmacometrics Syst Pharmacol
; 12(12): 1897-1910, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37803876
5.
Use of modelling and simulation techniques to support decision making on the progression of PF-04878691, a TLR7 agonist being developed for hepatitis C.
Br J Clin Pharmacol
; 73(1): 77-92, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21689140
6.
Population Pharmacokinetic Modeling and Probability of Pharmacodynamic Target Attainment for Ceftazidime-Avibactam in Pediatric Patients Aged 3 Months and Older.
Clin Pharmacol Ther
; 111(3): 635-645, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34687548
7.
Pharmacokinetics of Oral Nirmatrelvir/Ritonavir, a Protease Inhibitor for Treatment of COVID-19, in Subjects With Renal Impairment.
Clin Pharmacol Ther
; 112(4): 892-900, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35712797
8.
Innovative Randomized Phase I Study and Dosing Regimen Selection to Accelerate and Inform Pivotal COVID-19 Trial of Nirmatrelvir.
Clin Pharmacol Ther
; 112(1): 101-111, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35388471
9.
The use of the SAEM algorithm in MONOLIX software for estimation of population pharmacokinetic-pharmacodynamic-viral dynamics parameters of maraviroc in asymptomatic HIV subjects.
J Pharmacokinet Pharmacodyn
; 38(1): 41-61, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21088872
10.
Pregabalin Population Pharmacokinetic and Exposure-Response Analyses for Focal Onset Seizures in Children (4-16 years) and Adults, to Support Dose Recommendations in Children.
Clin Pharmacol Ther
; 110(1): 132-140, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33280106
11.
Pharmacokinetic and Pharmacodynamic Target Attainment in Adult and Pediatric Patients Following Administration of Ceftaroline Fosamil as a 5-Minute Infusion.
Clin Pharmacol Drug Dev
; 10(4): 420-427, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33465279
12.
The use of extrapolation based on modeling and simulation to support high-dose regimens of ceftaroline fosamil in pediatric patients with complicated skin and soft-tissue infections.
CPT Pharmacometrics Syst Pharmacol
; 10(6): 551-563, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33687148
13.
Comparing Model Performance in Characterizing the PK/PD of the Anti-Myostatin Antibody Domagrozumab.
Clin Transl Sci
; 13(1): 125-136, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31550073
14.
Phase 2 Study of the Safety, Pharmacokinetics and Efficacy of Ceftaroline Fosamil in Neonates and Very Young Infants With Late-onset Sepsis.
Pediatr Infect Dis J
; 39(5): 411-418, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32091493
15.
No Clinical Impact of CYP3A5 Gene Polymorphisms on the Pharmacokinetics and/or Efficacy of Maraviroc in Healthy Volunteers and HIV-1-Infected Subjects.
J Clin Pharmacol
; 59(1): 139-152, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30192390
16.
A population pharmacokinetic meta-analysis of maraviroc in healthy volunteers and asymptomatic HIV-infected subjects.
Br J Clin Pharmacol
; 65 Suppl 1: 76-85, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18333869
17.
Application of Quantitative Pharmacology Approaches in Bridging Pharmacokinetics and Pharmacodynamics of Domagrozumab From Adult Healthy Subjects to Pediatric Patients With Duchenne Muscular Disease.
J Clin Pharmacol
; 58(3): 314-326, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29023829
18.
Incidence of CXCR4 tropism and CCR5-tropic resistance in treatment-experienced participants receiving maraviroc in the 48-week MOTIVATE 1 and 2 trials.
Antivir Chem Chemother
; 27: 2040206619895706, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31856576
19.
Model Description Language (MDL): A Standard for Modeling and Simulation.
CPT Pharmacometrics Syst Pharmacol
; 6(10): 647-650, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28643440
20.
Levodopa slows progression of Parkinson's disease: external validation by clinical trial simulation.
Pharm Res
; 24(4): 791-802, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17308968