Detalhe da pesquisa
1.
Lack of germline transmission in male mice following a single intravenous administration of AAV5-hFVIII-SQ gene therapy.
Gene Ther
; 30(7-8): 581-586, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35132205
2.
Safety Findings of Dosing Gene Therapy Vectors in NHP With Pre-existing or Treatment-Emergent Anti-capsid Antibodies.
Toxicol Pathol
; 51(5): 246-256, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37921115
3.
Tralesinidase Alfa Enzyme Replacement Therapy Prevents Disease Manifestations in a Canine Model of Mucopolysaccharidosis Type IIIB.
J Pharmacol Exp Ther
; 382(3): 277-286, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35717448
4.
Natural history of Tay-Sachs disease in sheep.
Mol Genet Metab
; 134(1-2): 164-174, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34456134
5.
A Safe and Reliable Technique for CNS Delivery of AAV Vectors in the Cisterna Magna.
Mol Ther
; 28(2): 411-421, 2020 02 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31813800
6.
Intravitreal enzyme replacement preserves retinal structure and function in canine CLN2 neuronal ceroid lipofuscinosis.
Exp Eye Res
; 197: 108130, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32622066
7.
Effects of a selective androgen receptor modulator (SARM), GSK2849466A, on stress urinary incontinence and bladder activity in rats with ovariectomy-induced oestrogen deficiency.
BJU Int
; 125(6): 911-919, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32011085
8.
Ex Vivo Gene Therapy: Graft-versus-host Disease (GVHD) in NSG™ (NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ) Mice Transplanted with CD34+ Human Hematopoietic Stem Cells.
Toxicol Pathol
; 47(5): 656-660, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31064282
9.
Scientific and Regulatory Policy Committee Points to Consider: Histopathologic Evaluation in Safety Assessment Studies for PEGylated Pharmaceutical Products.
Toxicol Pathol
; 46(6): 616-635, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30092727
10.
Nonproliferative and Proliferative Lesions of the Rat and Mouse Endocrine System.
J Toxicol Pathol
; 31(3 Suppl): 1S-95S, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30158740
11.
Dermal toxicity studies: factors impacting study interpretation and outcome.
Toxicol Pathol
; 43(4): 474-81, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25389277
12.
Safety, pharmacokinetics and CNS distribution of tralesinidase alfa administered via intracerebroventricular infusion to juvenile cynomolgus monkeys.
Toxicol Rep
; 10: 357-366, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36923444
13.
Brain Alterations in Aged OVT73 Sheep Model of Huntington's Disease: An MRI Based Approach.
J Huntingtons Dis
; 11(4): 391-406, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36189602
14.
Young mice administered adult doses of AAV5-hFVIII-SQ achieve therapeutic factor VIII expression into adulthood.
Mol Ther Methods Clin Dev
; 26: 519-531, 2022 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36092364
15.
Substrate reduction therapy for Krabbe disease and metachromatic leukodystrophy using a novel ceramide galactosyltransferase inhibitor.
Sci Rep
; 11(1): 14486, 2021 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34262084
16.
Cyclic morphological changes in the beagle mammary gland.
Toxicol Pathol
; 38(6): 969-83, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20651098
17.
Chemical carcinogenesis of the gastrointestinal tract in rodents: an overview with emphasis on NTP carcinogenesis bioassays.
Toxicol Pathol
; 38(1): 188-97, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20019352
18.
Frequency of different estrous stages in purpose-bred beagles: a retrospective study.
Toxicol Pathol
; 36(7): 944-9, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19126790
19.
Effect of estrous cycle phase on clinical pathology values in beagle dogs.
Vet Clin Pathol
; 41(1): 71-6, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22250946
20.
Induction of transitional cell hyperplasia in the urinary bladder and aberrant crypt foci in the colon of rats treated with individual and a mixture of drinking water disinfection by-products.
Toxicol Pathol
; 31(2): 235-42, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12696585