Detalhe da pesquisa
1.
Endo-Lysosomal Cation Channels and Infectious Diseases.
Rev Physiol Biochem Pharmacol
; 185: 259-276, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-32748124
2.
Lysosomal TRPML1 regulates mitochondrial function in hepatocellular carcinoma cells.
J Cell Sci
; 135(6)2022 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35274126
3.
Human genome diversity data reveal that L564P is the predominant TPC2 variant and a prerequisite for the blond hair associated M484L gain-of-function effect.
PLoS Genet
; 17(1): e1009236, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33465068
4.
A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease.
EMBO J
; 38(2)2019 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30498130
5.
TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms.
Proc Natl Acad Sci U S A
; 114(41): E8595-E8602, 2017 10 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28923947
6.
Exploring the Dispersion and Electrostatic Components in Arene-Arene Interactions between Ligands and G4 DNA to Develop G4-Ligands.
J Med Chem
; 67(3): 2202-2219, 2024 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38241609
7.
Gut butyrate-producers confer post-infarction cardiac protection.
Nat Commun
; 14(1): 7249, 2023 11 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37945565
8.
Inhibition of HIV-1 Tat-mediated transcription by a coumarin derivative, BPRHIV001, through the Akt pathway.
J Virol
; 85(17): 9114-26, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21697490
9.
Targeting TPC2 sensitizes acute lymphoblastic leukemia cells to chemotherapeutics by impairing lysosomal function.
Cell Death Dis
; 13(8): 668, 2022 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35915060
10.
The gut microbiota regulates acute foreign body reaction and tissue repair after biomaterial implantation.
Biomaterials
; 289: 121807, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36166894
11.
Commensal gut microbiota-derived acetate and propionate enhance heart adaptation in response to cardiac pressure overload in mice.
Theranostics
; 12(17): 7319-7334, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36438501
12.
One-dimensional scanning multiphoton imaging reveals prolonged calcium transient and sarcomere contraction in a zebrafish model of doxorubicin cardiotoxicity.
Biomed Opt Express
; 12(11): 7162-7172, 2021 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34858707
13.
Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2.
Sci Rep
; 11(1): 8515, 2021 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33875769
14.
Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth.
Cell Chem Biol
; 28(8): 1119-1131.e27, 2021 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33626324
15.
TRPML Cation Channels in Inflammation and Immunity.
Front Immunol
; 11: 225, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32184778
16.
TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema.
JCI Insight
; 5(20)2020 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32931478
17.
Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function.
Elife
; 92020 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32167471
18.
Small Molecules for Early Endosome-Specific Patch Clamping.
Cell Chem Biol
; 24(7): 907-916.e4, 2017 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28732201
19.
Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes.
Nat Protoc
; 12(8): 1639-1658, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28726848
20.
Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells.
Cancer Res
; 77(6): 1427-1438, 2017 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28108508