Detalhe da pesquisa
1.
Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumannii.
Proc Natl Acad Sci U S A
; 119(51): e2213116119, 2022 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36512492
2.
Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth.
Nature
; 560(7717): 253-257, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30069049
3.
System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion.
PLoS Pathog
; 16(6): e1008485, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32589689
4.
Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones.
Malar J
; 20(1): 107, 2021 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33608015
5.
Systematic evaluation of structure-property relationships and pharmacokinetics in 6-(hetero)aryl-substituted matched pair analogs of amiloride and 5-(N,N-hexamethylene)amiloride.
Bioorg Med Chem
; 37: 116116, 2021 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33799173
6.
Efficacy, metabolism and pharmacokinetics of Ro 15-5458, a forgotten schistosomicidal 9-acridanone hydrazone.
J Antimicrob Chemother
; 75(10): 2925-2932, 2020 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32617557
7.
An in vitro toolbox to accelerate anti-malarial drug discovery and development.
Malar J
; 19(1): 1, 2020 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31898492
8.
Inhibition of Cytomegalovirus Replication with Extended-Half-Life Synthetic Ozonides.
Antimicrob Agents Chemother
; 63(1)2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30373792
9.
Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD-scid IL2Rγnull Mouse Model of Malaria.
Antimicrob Agents Chemother
; 63(3)2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30559138
10.
Parasite-Mediated Degradation of Synthetic Ozonide Antimalarials Impacts In Vitro Antimalarial Activity.
Antimicrob Agents Chemother
; 62(3)2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29263074
11.
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.
Antimicrob Agents Chemother
; 62(9)2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29941635
12.
Using Human Plasma as an Assay Medium in Caco-2 Studies Improves Mass Balance for Lipophilic Compounds.
Pharm Res
; 35(11): 210, 2018 Sep 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-30225649
13.
SAR of a new antischistosomal urea carboxylic acid.
Bioorg Med Chem Lett
; 28(23-24): 3648-3651, 2018 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30389288
14.
Progress in antischistosomal N,N'-diaryl urea SAR.
Bioorg Med Chem Lett
; 28(3): 244-248, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29317164
15.
Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria.
Bioorg Med Chem
; 26(11): 2996-3005, 2018 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29779669
16.
(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium.
Proc Natl Acad Sci U S A
; 111(50): E5455-62, 2014 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25453091
17.
Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strains.
Antimicrob Agents Chemother
; 60(8): 4501-10, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27161632
18.
Strategies to address low drug solubility in discovery and development.
Pharmacol Rev
; 65(1): 315-499, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23383426
19.
Enantiomers of nifurtimox do not exhibit stereoselective anti-Trypanosoma cruzi activity, toxicity, or pharmacokinetic properties.
Antimicrob Agents Chemother
; 59(6): 3645-7, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25845874
20.
ELQ-300 prodrugs for enhanced delivery and single-dose cure of malaria.
Antimicrob Agents Chemother
; 59(9): 5555-60, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26124159