Detalhe da pesquisa
1.
Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a.
Proc Natl Acad Sci U S A
; 114(14): 3750-3755, 2017 04 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28320941
2.
A dynamic pharmacophore drives the interaction between Psalmotoxin-1 and the putative drug target acid-sensing ion channel 1a.
Mol Pharmacol
; 80(5): 796-808, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21825095
3.
The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype- and species-dependent: Importance of interactions at the channel subunit interface and potential for engineering selective analogues.
Biochem Pharmacol
; 163: 381-390, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30849303
4.
PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a.
Neuropharmacology
; 99: 650-7, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26320544
5.
Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a.
Br J Pharmacol
; 172(20): 4985-95, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26248594