1.
Bioorg Med Chem
; 12(4): 655-62, 2004 Feb 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-14759726
RESUMO
Molecular modeling on various well-known glitazones carrying a pyridine ring instead of benzene ring as the middle linker unit showed conformational rigidity as compared to their parent molecules. Blocking the lone pair of electrons on the pyridine N, made them flexible once again. A few representatives of these analogues were synthesized and their efficacy as PPARgamma agonists evaluated.