Detalhe da pesquisa
1.
Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus.
Bioorg Med Chem Lett
; 27(9): 2069-2073, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28284804
2.
Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus.
Bioorg Med Chem Lett
; 27(9): 2063-2068, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28284809
3.
Discovery of spirocyclic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors.
Bioorg Med Chem Lett
; 19(13): 3398-404, 2009 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19481932
4.
Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitors.
Bioorg Med Chem Lett
; 19(18): 5314-20, 2009 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19682899
5.
Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement.
J Med Chem
; 52(16): 5009-12, 2009 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-19645482
6.
Enhanced characterization of complex proteomic samples using LC-MALDI MS/MS: exclusion of redundant peptides from MS/MS analysis in replicate runs.
Anal Chem
; 77(23): 7816-25, 2005 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16316193
7.
High-speed, high-resolution monolithic capillary LC-MALDI MS using an off-line continuous deposition interface for proteomic analysis.
Anal Chem
; 77(8): 2323-31, 2005 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15828764
8.
Coumarin tags for analysis of peptides by MALDI-TOF MS and MS/MS. 2. Alexa Fluor 350 tag for increased peptide and protein Identification by LC-MALDI-TOF/TOF MS.
Anal Chem
; 77(7): 2085-96, 2005 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15801742
9.
Closely spaced external standard: a universal method of achieving 5 ppm mass accuracy over the entire MALDI plate in axial matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Rapid Commun Mass Spectrom
; 17(19): 2177-87, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-14515315
10.
Increased identification of peptides by enhanced data processing of high-resolution MALDI TOF/TOF mass spectra prior to database searching.
Anal Chem
; 76(20): 6017-28, 2004 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15481949
11.
A universal denoising and peak picking algorithm for LC-MS based on matched filtration in the chromatographic time domain.
Anal Chem
; 75(22): 6314-26, 2003 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-14616016