Glucagon-like peptide-1 attenuates diabetes-associated osteoporosis in ZDF rat, possibly through the RAGE pathway.

BACKGROUND: Diabetes-associated osteoporosis are partly caused by accumulation of advanced glycation endproducts (AGEs). Glucagon-like peptide-1 (GLP-1) has been shown to regulate bone turnover. Here we explore whether GLP-1 receptor agonist (GLP1RA) can have a beneficial effect on bone in diabetes by ameliorating AGEs. METHODS: In the present study, we evaluated the effects of the GLP-1 receptor agonist liraglutide, insulin and dipeptidyl peptidase-4 inhibitor saxagliptin on Zucker diabetic fatty rats. Meanwhile, we observed the effect of GLP-1 on AGEs-mediated osteoblast proliferation and differentiation and the signal pathway. RESULTS: Liraglutide prevented the deterioration of trabecular microarchitecture and enhanced bone strength. Moreover, it increased serum Alpl, Ocn and P1NP levels and decreased serum CTX. In vitro we confirmed that GLP-1 could attenuate AGEs-mediated damage in osteogenic proliferation and differentiation. Besides, GLP-1 down-regulated the ROS that caused by AGEs and the mRNA and protein expression of Rage . CONCLUSIONS: Altogether, our findings suggest that GLP-1 receptor agonist promotes osteoblastogenesis and suppresses bone resorption on obese type 2 diabetic rats to a certain degree. The mechanism of these effects may be partly mediated by AGEs-RAGE-ROS pathway via the interaction with GLP-1 receptor.

Identification and exploration of the GRF and GIF families in maize and foxtail millet.

Plant growth and development are dependent on complex regulatory networks to adapt various environments. The growth regulatory factor (GRF) and GRF-interacting factor (GIF) families have been shown to control growth in various plant species. There are growing evidences that GRFs and GIFs can improve crop genetic transformation efficiency. In this study, we identified and classified 17 ZmGRFs, 10 SiGRFs, 4 ZmGIFs and 3 SiGIFs in maize (Zea mays L.) and foxtail millet (Setaria italica L.) using updated genome data. Many ABREs (Abscisic Acid-responsive elements) were present in the promoter regions of GRFs by analysis, and the expression levels of ZmGRF4, 9, 12, 14 and ZmGIF2 were associated with the Abscisic Acid (ABA) response. Furthermore, ZmGRF9 showed collinearity with AtGRF5 between Arabidopsis and maize. ZmGRF9 conservatively interacts with ZmGIF 2, 3, and 4. As a result, we systematically identified GRF and GIF family members, analyzed the regulatory network, and found that exogenous ABA inhibited the expression of GRFs, regulating responses to stress in the environment. Supplementary Information: The online version contains supplementary material available at 10.1007/s12298-022-01234-z.

PDA-cross-linked beta-cyclodextrin: a novel adsorbent for the removal of BPA and cationic dyes.

In this study, 4,4'-(hexafluoroisopropene) diphthalic acid (PDA)-CD polymers containing ß-cyclodextrin (CD) were synthesized for the adsorption of endocrine disrupting chemicals (EDCs) and dyes. It features great adsorption of bisphenol A (BPA), methylene blue (MB) and neutral red (NR). The maximum adsorption capacities of MB, NR and BPA can reach 113.06, 106.8 and 51.74 mg/g, respectively. The tandem adsorption results revealed that adsorptions of dyes and BPA onto PDA-CD polymer were two independent processes: non-polar BPA entrapment by cyclodextrin cavities while dyes were captured by the carboxyl groups and π-π stacking interactions. The adsorption processes performed well in a wide range of pH (4.0-10.0) and were not affected by fulvic acid (FA) and inorganic ions.

[Determination of polychlorinated biphenyls in water by stable isotope dilution through automatic solid-phase extraction membrane coupled to gas chromatography-mass spectrometry].

OBJECTIVE: The method for analyzing of 20 polychlorinated biphenyls(PCBs) in water by stable isotope internal standard-automatic solid-phase extraction membrane(auto SPEM) coupled to gas chromatography-mass spectrometer(GC-MS) was established, and applied to the analysis of trace PCBs in water samples. METHODS: The sample backgrounds of bottled mineral water production in Fuzhou(groundwater), inland water in Fuzhou university city(surface water), tap water(pipe tip water) and stream water in Xiyuan Gong(water source of life) were analyzed by GC-MS. Surrogate solution(SS)internal standards including ~(13)C_(12 )PCBs stable isotope was used for quantification. The method was confirmed by calculating recovery rate(RR) and relative standard deviation(RSD) of spiked water samples(20, 40 and 80 ng/L, n=7). And recovery rates of SS were used to evaluate the effect of the pretreatment. And the method was used to determine PCBs of a total of 17 cross-sectiona river water in minjiang river tributaries upstream to the downstream estuary. RESULTS: The method detection limits(MDL) were 1. 9-6. 6 ng/L, and RRs were 70. 9%-127%, and RSDs were 0. 5%-13%. The RRs of SS were 40%-90%. Positive sample was not detected. CONCLUSION: The method of auto SPEM is less solvent, more automatic than traditional manual SPE. And the method is more accurate and reliable by stable isotope internal standard coupled to GC-MS. Therefore, it is useful for the trace PCBs determination of waters.

Polymerization of Isoprene Promoted by Aminophosphine(ory)-Fused Bipyridine Cobalt Complexes: Precise Control of Molecular Weight and cis-1,4- alt-3,4 Sequence.

Ligands N-(dialkyl or arylphosphino)-(2,2'-bipyridin)-6-amine (L1, aryl = Ph; L2, alkyl = tBu; L3, alkyl = adamantyl (Ad)) as well as the corresponding oxidized N-(2,2'-bipyridin-6-yl)- P, P-dialkyl or aryl phosphinic amide (L4, aryl = Ph; L5, alkyl = tBu; L6, alkyl = Ad) congeners were designed and coordinated to cobalt dichloride. The structures of formed complexes were characterized by IR and elemental analyses, as well as characterizations of the X-ray diffractions for complexes Co4 and Co6, which revealed the cobalt center is expectedly pentacoordinated in a distorted trigonal bipyramidal configuration with a prolonged Co-O(═P) bond . In combination with MMAO, complex Co2 was highly active in cis-1,4- alt-3,4 enchained polymerization. The hemilabile nature of O═P is possible for the alternating η4- cis-1,4 and η2-3,4 coordination, and insertion at the metal-carbon bond ensued. In combination with AlEt2Cl, each of complexes Co4, Co5, and Co6 was capable of converting isoprene to polyisoprene in a control mode with observed polymerization rate constants ( kobs = 0.1531 L mol-1 min-1 (Co4), 0.1382 L mol-1 min-1 (Co5), and 0.0902 L mol-1 min-1 (Co6)). The activation energy of the polymerization by Co4 falls in the range of 27-31 kJ/mol by determining kobs values at 0, 30, and 50 °C. The 13C NMR analyses of the obtained polyisoprene revealed that complexes Co4, Co5, and Co6 have a cis-1,4 selectivity of 86.6-93.4% with a 3,4 selectivity of 6.6-13.4%. This catalyst system can also be applied to block copolymerization of isoprene and myrcene in a living cis-1,4 fashion; therefore, a new biosourced monomer-based elastomer has been achieved.

Determination of chloropropanol esters and glycidyl esters in nutritional foods by gas chromatography-tandem mass spectrometry based on acid hydrolysis and solid-phase extraction.

This study presents a method based on acid transesterification and the purification by solid-phase extraction (SPE) coupled with gas chromatography-tandem mass spectrometry for quantifying 3- and 2-monochloropropanediol esters (3-MCPDE, 2-MCPDE) and glycidyl esters (GE) in nutritional foods. The fat was extracted by liquid-liquid extraction with petroleum ether and diethyl ether after the sample was hydrolysed with ammonia. Then the extract was purified by a SPE cartridge filled with the aminopropyl sorbents. It was demonstrated that the optimal elution volume for 3-MCPDE, 2-MCPDE and GE greatly depended on the sample matrix and varied from 6 to 12 mL for four different kinds of food matrices. All three analytes in the sample solution could be fully collected in the first 10-12 mL of eluate. By this way, monoacylglycerols commonly present in the samples were fully removed. Therefore, the overestimation of GE quantification was effectively eliminated. The modified analytical procedure was fully validated in a single laboratory and has been recommended as a Chinese Food Safety National Standard. In addition, two derivatisation agents, heptafluorobutyrylimidazole and phenylboronic acid, were proved to be equivalent in method accuracy and precision for the quantification of three analytes.

Biofunctionalized dendritic polyaniline nanofibers for sensitive electrochemical immunoassay of biomarkers.

Multi-armed dendritic polyaniline nanofibers (MPANFs) were first synthesized and functionalized with horseradish peroxidase (HRP) and carcinoembryonic antibody (anti-CEA) for highly efficient electrochemical immunoassay of carcinoembryonic antigen (CEA, as a model analyte here) in this work. Transmission electron microscope (TEM) and scanning electron microscope (SEM) techniques were employed to characterize the synthesized MPANFs. By using anti-CEA-conjugated core-shell gold-Fe(3)O(4) nanocomposites (GoldMag) as immunosensing probes and biofunctionalized MPANFs as molecular tags, a new sandwich-type homogeneous immunoassay strategy was developed for the determination of CEA by coupling with a home-made flow-through magneto-controlled microfluidic device. Under optimal conditions, the electrochemical immunoassay exhibited a wide dynamic range of four orders of magnitude from 1.0 pg mL(-1) to 50 ng mL(-1) with a low detection limit of 0.1 pg mL(-1) CEA at 3σ. Intra- and inter-assay coefficients of variation were below 10%. The assayed results for clinical serum specimens with the electrochemical immunoassay were received in good accordance with the results obtained from the referenced enzyme-linked immunosorbent assay (ELISA) method.

A simple and versatile strategy for sensitive SIDA-UHPLC-MS/MS analysis of Alternaria toxins in olive oil.

Alternaria toxins are naturally occurring contaminants found in natural products. Given the prevalence of Alternaria toxins and the complexity of oil-rich matrices, achieving ultra-trace analysis has become a daunting task. A new sample pretreatment technique, i.e., cold-induced liquid-liquid microextraction combined with serially-coupled-columns for SIDA-UHPLC-MS/MS, was developed and reported for the first time. Theoretical and experimental investigations on the mechanism and key parameters revealed that the proposed method achieved simultaneous purification and enrichment in one-step sample extraction with a superior limit of quantitation (0.15-1.5 µg kg-1), without further sample manipulation, such as fat removal or solvent exchange procedures prior to LC-MS. The method was validated taking into consideration EU guidelines and showed acceptable linearity (r ≥ 0.9991), accuracy with recoveries between 75 and 114% and precision with RSD≤9.7% for all of the analytes studied. It was successfully applied to the analysis of twenty samples sourced from the Mediterranean region in order to gain first insights into Alternaria toxins contaminations in olive oils. This technical approach is well suited for large-scale studies in a high-throughput and cost-effective quality assurance laboratory environments, and it has the potential to detect ultra-trace levels of toxins in complex samples, which may lead to the development of new and sustainable sample preparation procedures.

Teratogenicity of 30 nm Aluminum Oxide Nanoparticles (Al2O3NPs) in Rats by Gavage.

Aluminum oxide nanoparticles (Al2O3NPs) are one class of widely used nanomaterials. However, the teratogenicity toxicity of Al2O3NPs in mammal remains poorly understood. This study was aimed to evaluate the teratogenicity of Al2O3NPs in Sprague Dawley (SD) rats by gavage and to compare the effects of Al2O3NPs to those of equivalent dose of microscale aluminum oxide (bulk Al2O3). Sixty pregnant rats were randomly divided into 5 groups and treated with 100 and 200 mg/kg body weight (bw) Al2O3NPs (30 nm), 200 mg/kg bulk Al2O3, deionized water (as the negative control), and 300 mg/kg aspirin (as the positive control). Rats were exposed daily by oral gavage from the 7th day of gestation for 10 consecutive days and sacrificed on the 20th day of gestation. Results of the study showed that there were no significant effects of Al2O3NPs on pregnant rats (clinical signs, body weight, food consumption, ovary and uterus weight, number of corpora lutea) and fetuses (body weight, sex, body length, tail length, skeletal and visceral development). Under the experimental conditions of the present study, 10 consecutive days of repeated oral administration of Al2O3NPs at doses of up to 200 mg/kg/day did not induce any treatment-related teratogenicity in SD rats. Accordingly, the NOAEL was determined to be 200 mg/kg Al2O3NPs (106 mg Al/kg bw/day) in rats. The teratogenic effects of Al2O3NPs in rats were comparable to those of the bulk Al2O3 of same doses (200 mg/kg).

Curved π-Conjugated Helical Carbon Frameworks: Syntheses, Structural Analyses, and Properties.

Two enantiomers with helical carbon frameworks (M-HCFa and P-HCFa) and their conformational isomers (M-HCFb and P-HCFb) have been synthesized and characterized. The single-crystal analysis revealed the novel structures in which three propeller blades spiro-fused on two central benzene rings. The optical properties were further investigated, and stable bipolar electrochemiluminescence emissions were discovered for the first time existing in helical carbon frameworks, which provide new insights into the future development of high-performance molecular luminescent devices.

Development and validation of a novel approach based on ultrasonic-assisted enzymatic extraction and RP-UHPLC for simultaneous determination of astaxanthin isomers and alpha-tocopherol in Haematococcuspluvialis derived supplements.

A rapid, effective andgreenmethod was developed for simultaneous determination of total (free and esterified) astaxanthin (AX) isomers (all-E, 9Z and 13Z) and alpha-tocopherol(AT) in Haematococcuspluvialis derived supplements. The new method employed a highly efficient ultrasonic-assisted enzymatic extraction (UAEE) techniqueto perform deesterificationwith Cholesterol esterase from Pseudomonas fluorescenspermitting the concurrent detection. The subsequent RP-UHPLC method for separating and measuring was performed on a simple C18 column within 10.5 min by using methanol and ammonium acetate as mobile phase with a gradient elution. The proposed method was validated according to international guidelines and itproved to be highly accurate and robust. The optimized UHPLC method allowed easy transfer to HPLC, and allowed rapid analysis of active ingredients profiling in H. derived supplements.To our knowledge, this is the first quantification approach describing the rapid simultaneous analysis of the functional lipophilic substances including AX isomers in H. derived supplements using UAEE technique combined with RP-UHPLC.Moreover, this holistic approachcan be used to identify whether AX products are of natural origin or chemical synthesis, and may find more applications in new forms of H. derived productswith complexbiological matrix for more research on the bioavailability of AXisomersfrom natural source.

KNbO3/ZnO heterojunction harvesting ultrasonic mechanical energy and solar energy to efficiently degrade methyl orange.

In this paper, KNbO3/ZnO nanocomposite was synthesized and used in piezo/photocatalytic degradation of methyl orange (MO) under simulated sunlight and ultrasonic vibration. Under simulated solar light, the optimal KNbO3/ZnO sample presented a MO degradation rate of 0.047 min-1, which is 2.47 times higher than that of ZnO. The promotion effect of KNbO3 on ZnO was also observed in the piezoelectric catalytic reaction. In addition, the co-utilization of solar and mechanical energy can further increase the MO degradation rate. Piezoelectric property and photoresponse capability are the origins of the piezo/photo catalytic behavior of the KNbO3/ZnO composite. Owing to the different band potentials of KNbO3 and ZnO, the electric potential field at their interface can drive the second distribution of the photo/piezoinduced charge carriers and hence promote the photo/piezocatalytic activity. This phenomenon was verified by the analysis on transient photocurrent and piezocurrent response. Trapping experiments on reactive species were also conducted. Superoxide radicals, holes, and hydroxyl radicals were found to be the main reactive species during the photo/piezocatalytic reaction. Recycling test showed that the KNbO3/ZnO composite exhibited good catalytic stability during six consecutive uses. Given its advantages of good catalytic activity and stability, the synthesized KNbO3/ZnO nanocomposite material has great potential in the further use of solar and mechanical energy to develop new water purification technologies.

The functional analysis of transiently upregulated miR-101 suggests a "braking" regulatory mechanism during myogenesis.

Skeletal muscle differentiation is a highly coordinated process that involves many cellular signaling pathways and microRNAs (miRNAs). A group of muscle-specific miRNAs has been reported to promote myogenesis by suppressing key signaling pathways for cell growth. However, the functional role and regulatory mechanism of most non-muscle-specific miRNAs with stage-specific changes during differentiation are largely unclear. Here, we describe the functional characterization of miR-101a/b, a pair of non-muscle-specific miRNAs that show the largest change among a group of transiently upregulated miRNAs during myogenesis in C2C12 cells. The overexpression of miR-101a/b inhibits myoblast differentiation by suppressing the p38/MAPK, Interferon Gamma, and Wnt pathways and enhancing the C/EBP pathway. Mef2a, a key protein in the p38/MAPK pathway, was identified as a direct target of miR-101a/b. Interestingly, we found that the long non-coding RNA (lncRNA) Malat1, which promotes muscle differentiation, interacts with miR-101a/b, and this interaction competes with Mef2a mRNA to relieve the inhibition of the p38/MAPK pathway during myogenesis. These results uncovered a "braking" role in differentiation of transiently upregulated miRNAs and provided new insights into the competing endogenous RNA (ceRNA) regulatory mechanism in myoblast differentiation and myogenesis.

Characterization of a wheat-Thinopyrum bessarabicum (T2JS-2BS.2BL) translocation line.

Thinopyrum bessarabicum (2n = 2x = 14, JJ or E(b)E(b)) is an important genetic resource for wheat improvement due to its salinity tolerance and disease resistance. Development of wheat-Th. bessarabicum translocation lines will facilitate its practical utilization in wheat improvement. In this study, a novel wheat-Th. bessarabicum translocation line T2JS-2BS.2BL, which carries a segment of Th. bessarabicum chromosome arm 2JS was identified and further characterized using sequential chromosome C-banding, genomic in situ hybridization (GISH), dual-color fluorescent in situ hybridization (FISH) and DNA markers. The translocation breakpoint was mapped within bin C-2BS1-0.53 of chromosome 2B through marker analysis. Compared to the Chinese Spring (CS) parent and to CS-type lines, the translocation line has more fertile spikes per plant, longer spikes, more grains per spike and higher yield per plant, which suggests that the alien segment carries yield-related genes. However, plants with the translocation are also taller, head later and have lower 1,000-kernel weight than CS or CS-type lines. By using markers specific to the barley photoperiod response gene Ppd-H1, it was determined that the late heading date was conferred by a recessive allele located on the 2JS segment. In addition, four markers specific for the translocated segment were identified, which can be used for marker-aided screening.

Cost-effectiveness of nucleoside analog therapy for hepatitis B in China: a Markov analysis.

OBJECTIVES: The aim of this study was to investigate the economic consequences of nucleoside analog therapy for hepatitis B treatment in China. METHODS: A cost-utility analysis of treatments for HBeAg-positive and HBeAg-negative chronic hepatitis B (CHB) was conducted using a Markov model, in which patients' yearly transitions between different health states were tracked. Patients were tracked as they moved between the following health states: CHB, HBeAg seroconversion (HBeAg-positive CHB patients can have this special health state), virologic resistance, virologic response, compensated cirrhosis, decompensated cirrhosis, hepatocellular carcinoma, liver transplantation, and death. The transition parameters were derived either from systematic reviews of the literature or from previous economic studies. Cost and utility data came from studies based on a Chinese CHB cohort. One-way sensitivity analyses as well as second-order Monte Carlo and probabilistic sensitivity analyses were performed. RESULTS: The entecavir strategy yielded the most quality-adjusted life years (QALYs) for both HBeAg-positive and HBeAg-negative patients when compared with the "no treatment," the lamivudine, the adefovir, and the telbivudine strategies. The risks of complications and mortality also decreased. In the economic analysis, the "no treatment" strategy was the least effective, whereas the entecavir strategy was both the least expensive and the most cost-effective option, followed by telbivudine and lamivudine. The probabilistic sensitivity analysis showed that the entecavir strategy would result in improved cost-effectiveness in >90% of cases at a threshold of $20,000 per QALY. In a one-way sensitivity analysis, the most influential parameters impacting the model's robustness were the utilities of the CHB and virologic response health states. CONCLUSIONS: In China, when treating both HBeAg-positive and HBeAg-negative CHB populations, entecavir is the most cost-effective option when compared with lamivudine, adefovir, and telbivudine.

(E)-1-(4-Chloro-phen-yl)-3-[4-(2,3,4,6-tetra-O-acetyl-ß-d-allopyranos-yloxy)phen-yl]prop-2-en-1-one.

The asymmetric unit of the title compound, C(29)H(29)ClO(11), contains two independent mol-ecules of similar geometry, both adopting an E conformation about the C=C double bond. The dihedral angles formed by benzene rings are 10.73 (16) and 13.79 (18)°. The pyran-oside rings adopt a chair conformation. Intra-molecular C-H⋯O close contacts occur. The crystal packing is stabilized by inter-molecular C-H⋯O hydrogen bonds.

1-[4-(ß-d-Allopyranos-yloxy)benzyl-idene]semicarbazide hemihydrate.

The mol-ecule of the title compound, C(14)H(19)N(3)O(7)·0.5H(2)O, exhibits an E conformation about the C=N double bond. The water mol-ecule possesses crystallographically imposed twofold symmetry. In the crystal structure, the mol-ecules are connected by inter-molecular O-H⋯O and N-H⋯O hydrogen bonds into a three-dimensional network.

Polydopamine modified cyclodextrin polymer as efficient adsorbent for removing cationic dyes and Cu2.

An eco-friendly polydopamine composite adsorbent (CD-CA/PDA) based on cyclodextrin polymer was prepared for cationic dyes and metals removing. CD-CA/PDA, combining the advantages of cyclodextrin and polydopamine, which has quite abundant carboxyl and catechol groups, so methylene blue (MB), malachite green (MG), crystal violet (CV) and copper ion (Cu2+) can be easily removed by electrostatic force. Adsorption kinetic results showed all adsorption process fitted well with pseudo-second-order model. In addition, the isotherm fitted results showed that the adsorption processes of CD-CA/PDA on MG and Cu2+ were consistent with sips model, while the adsorption processes of MB and CV agreed well with Freundlich and Langmuir model, respectively. The fitted adsorption capacities of CD-CA/PDA for MB, MG, CV and Cu2+ were 582.95 mg/g (1.82 mmol/g), 1174.67 mg/g (3.22 mmol/g), 473.01 mg/g (1.16 mmol/g) and 73.64 mg/g (1.16 mmol/g), respectively. Moreover, it is worth noting that cationic dyes have no competitive adsorption in series. CD-CA/PDA is of great recyclability, and can be reused by at least 5 times. Due to the facile and eco-friendly preparation process and excellent adsorption performance, CD-CA/PDA has a great potential in the field of wastewater treatment.

Superior adsorption capacity of functionalised straw adsorbent for dyes and heavy-metal ions.

Dyes and heavy-metal ions are common pollutants in printing and dyeing wastewater, and are thus attracting considerable attention. Herein, an eco-friendly straw-based adsorbent, WS-CA-AM, was prepared by grafting with acrylamide (AM) and citric acid (CA) groups to remove representative dyes and heavy metals from aqueous solution. The adsorption capacities of WS-CA-AM for methyl orange (MO) and methylene blue (MB) were 3053.48 and 120.84 mg/g, which were 54 and 3 times those of unmodified straw, respectively. Moreover, the adsorption capacities for MB, MO, Cr2O72- and Cu2+ in the mixed system increased by 210%, 133%, 196% and 151%, respectively, compared with those in the single system. The significant increase in adsorption capacity can be attributed to the collaborative effect through electrostatic attraction. The functional groups and adsorbed pollutants all served as adsorption sites for pollutants. These results indicate that WS-CA-AM is a potential applicant for the removal of dyes and heavy-metal ions from mixed aqueous solution.

A novel hollow-sphere cyclodextrin nanoreactor for the enhanced removal of bisphenol A under visible irradiation.

A novel hybrid nanoreactor with spatially separated co-catalysts (SH-CD-Au@CdS@MnOx) was successfully synthesised to remove bisphenol-A (BPA) from water by visible light. The photooxidation intermediates, degradation pathway of BPA and the enhancement mechanism were investigated in particular. Gold (Au) nanoparticles modified with SH-ß-cyclodextrin and MnOx nanoparticles were selectively decorated on the interior and exterior surface of hollow CdS nanoreactors, respectively. The directed migration of photogenerated electrons and holes induced by spatially separated co-catalysts lead to high utilization of light, and SH-ß-cyclodextrin modification makes catalytic active sites more accessible for oxidation intermediates. Compared with pristine CdS, the hybrid nanoreactor increased the BPA photooxidation reaction rate and the TOC removal efficiency by 5.6-fold and 3.6-fold, respectively. Moreover, the toxic intermediates, such as phenol, were further degraded by visible light. Molecular orbital calculation predicted that the sites on BPA molecule values of (FED2HOMO + FED2LUMO) can be easier attacked by the radical, whereas atoms with higher values of 2FED2HOMO can easily be extracted into electrons. Thus, SH-CD-Au@CdS@MnOx can provide a new strategy for the high-efficiency photodegradation of endocrine disrupter compounds in advanced water treatments.