Influence of land use change on habitat quality: a case study of coal mining subsidence areas.

Revealing the spatiotemporal evolution characteristics and key driving processes behind the habitat quality is of great significance for the scientific management of production, living, and ecological spaces in resource-based cities, as well as for the efficient allocation of resources. Focusing on the largest coal-mining subsidence area in Jiangsu Province of China, this study examines the spatiotemporal evolution of land use intensity, morphology, and functionality across different time periods. It evaluates the habitat quality characteristics of the Pan'an Lake area by utilizing the InVEST model, spatial autocorrelation, and hotspot analysis techniques. Subsequently, by employing the GTWR model, it quantifies the influence of key factors, unveiling the spatially varying characteristics of their impact on habitat quality. The findings reveal a notable surge in construction activity within the Pan'an Lake area, indicative of pronounced human intervention. Concurrently, habitat degradation intensifies, alongside an expanding spatial heterogeneity in degradation levels. The worst habitat quality occurs during the periods of coal mining and large-scale urban construction. The escalation in land use intensity emerges as the primary catalyst for habitat quality decline in the Pan'an Lake area, with other factors exhibiting spatial variability in their effects and intensities across different stages.

Discovery and structure-activity relationship studies of N-substituted indole derivatives as novel Mcl-1 inhibitors.

Myeloid cell leukemia-1 (Mcl-1) is an important antiapoptotic protein functioning through protein-protein interactions. We discovered LSL-A6 (2-((2-carbamoyl-1-(3-(4-methoxyphenoxy)propyl)-1H-indol-6-yl)oxy)acetic acid) with a novel N-substituted indole scaffold to interfere Mcl-1 binding as a novel Mcl-1 inhibitor. Molecular modeling indicated that this compound binds with Mcl-1 by interaction with P2 and R263 hot-spots. Structure modification focused on several moieties including indole core, hydrophobic tail and acidic chain were conducted and structure-activity relationship was analyzed. The most potent compound 24d which exhibited Ki value of 110nM for interfering Mcl-1 binding was obtained after hit-to-lead modification.

Spatial-Temporal Patterns of Ecosystem Services Supply-Demand and Influencing Factors: A Case Study of Resource-Based Cities in the Yellow River Basin, China.

The aim of this study was to reveal the spatiotemporal pattern of the supply and demand of ecosystem services (ESs), as well as the significant driving factors for understanding the impact of human activities on the natural ecosystem. To provide a scientific basis for formulating regional sustainable development strategies that enhance human well-being, resource-based cities in the Yellow River Basin (YRB) were selected as the case study. The supply and demand of ecosystem services in these cities from 2000 to 2020 were measured. The spatiotemporal evolution of the supply-demand relationship was illustrated by taking its coordination degree. In addition, geographical detector and geographically weighted regression (GWR) models were applied to quantify the spatiotemporally varying effects of natural and socioeconomic factors on the ES supply--demand relationship. The results showed that resource-based cities in the YRB were experiencing expansion in supply and demand overall, but the supply-demand relationship tended to be tense. The northwest YRB had higher coordination values of supply-demand, while lower values were found in the southeast YRB. Moreover, the relationship between supply and demand was significantly affected by natural and socioeconomic factors, such as elevation, slope, precipitation, land-use type, population density, and gross domestic product (GDP) per land. Furthermore, the GWR model suggested that the effects of driving factors on the supply-demand relationship had notable spatial heterogeneity. The coordination of ES supply-demand in the resource-based cities of southeast YRB was mainly influenced by socioeconomic factors, while that of the west YRB was mainly influenced by natural factors. Our study suggested that it is necessary to enhance the awareness of environmental protection, pay attention to ecological restoration, and avoid unreasonable human disturbance to the ecosystem.

Photoresponsive cross-linked polymeric particles for phototriggered burst release.

We synthesized a series of cross-linked photoresponsive polymeric particles with photolabile monomers and cross-linkers through miniemulsion polymerization. These particles are quite stable in dark, while light irradiation caused the breakage of particles and the efficient release of encapsulated contents up to 95% based on Nile red fluorescence. Photoswitches of particle systems were confirmed by fluorescence spectroscopy, SEM and colorimetry. Particle uptake and triggered release in RAW264.7 cells were confirmed by fluorescein diacetate loaded particles.