Detalhe da pesquisa
1.
Promoterless, Nuclease-Free Genome Editing Confers a Growth Advantage for Corrected Hepatocytes in Mice With Methylmalonic Acidemia.
Hepatology
; 73(6): 2223-2237, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32976669
2.
Secreted histidyl-tRNA synthetase splice variants elaborate major epitopes for autoantibodies in inflammatory myositis.
J Biol Chem
; 289(28): 19269-75, 2014 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24898250
3.
Novel AAV-mediated genome editing therapy improves health and survival in a mouse model of methylmalonic acidemia.
PLoS One
; 17(9): e0274774, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36126056
4.
Serum-circulating His-tRNA synthetase inhibits organ-targeted immune responses.
Cell Mol Immunol
; 18(6): 1463-1475, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31797905
5.
Cholesteryl ester hydrolase activity is abolished in HSL-/- macrophages but unchanged in macrophages lacking KIAA1363.
J Lipid Res
; 51(10): 2896-908, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20625037
6.
An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling.
Chem Biol
; 13(10): 1041-50, 2006 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17052608
7.
Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
J Med Chem
; 48(5): 1576-87, 2005 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-15743199
8.
A semisynthetic strategy to generate phosphorylated and acetylated histone H2B.
Chembiochem
; 10(13): 2182-7, 2009 Sep 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-19623598
9.
Synthesis, structure, and activity of diclofenac analogues as transthyretin amyloid fibril formation inhibitors.
J Med Chem
; 45(2): 321-32, 2002 Jan 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-11784137
10.
Human tRNA synthetase catalytic nulls with diverse functions.
Science
; 345(6194): 328-32, 2014 Jul 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-25035493
11.
Internally deleted human tRNA synthetase suggests evolutionary pressure for repurposing.
Structure
; 20(9): 1470-7, 2012 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-22958643
12.
Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action.
Angew Chem Int Ed Engl
; 42(24): 2758-61, 2003 Jun 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-12820260
13.
Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe.
Chem Biol
; 16(9): 1001-12, 2009 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-19778728
14.
Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B.
ACS Chem Biol
; 4(11): 958-68, 2009 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-19799466
15.
Systems- and molecular-level elucidation of signaling processes through chemistry.
Sci Signal
; 1(42): pe45, 2008 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-18941136
16.
Serine hydrolase KIAA1363: toxicological and structural features with emphasis on organophosphate interactions.
Chem Res Toxicol
; 19(9): 1142-50, 2006 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16978018
17.
A brain detoxifying enzyme for organophosphorus nerve poisons.
Proc Natl Acad Sci U S A
; 102(17): 6195-200, 2005 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-15840715
18.
Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors.
Bioorg Med Chem Lett
; 15(4): 1075-8, 2005 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15686915
19.
Potent and selective structure-based dibenzofuran inhibitors of transthyretin amyloidogenesis: kinetic stabilization of the native state.
J Am Chem Soc
; 127(18): 6662-71, 2005 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-15869287
20.
A missense mutation in human fatty acid amide hydrolase associated with problem drug use.
Proc Natl Acad Sci U S A
; 99(12): 8394-9, 2002 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-12060782