Detalhe da pesquisa
1.
Design of rigid protein-protein interaction inhibitors enables targeting of undruggable Mcl-1.
Proc Natl Acad Sci U S A
; 120(21): e2221967120, 2023 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37186857
2.
Conformationally Controlled sp3 -Hydrocarbon-Based α-Helix Mimetics.
Angew Chem Int Ed Engl
; 62(23): e202301209, 2023 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37017133
3.
In-Cell Quantification of Drugs by Magic-Angle Spinning Dynamic Nuclear Polarization NMR.
J Am Chem Soc
; 144(15): 6734-6741, 2022 04 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35385274
4.
Relating Conformational Equilibria to Conformer-Specific Lipophilicities: New Opportunities in Drug Discovery.
Angew Chem Int Ed Engl
; 61(7): e202114862, 2022 02 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34913249
5.
Skipped Fluorination Motifs: Synthesis of Building Blocks and Comparison of Lipophilicity Trends with Vicinal and Isolated Fluorination Motifs.
J Org Chem
; 86(2): 1882-1900, 2021 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33400526
6.
Differential uptake, kinetics and mechanisms of intracellular trafficking of next-generation antisense oligonucleotides across human cancer cell lines.
Nucleic Acids Res
; 47(9): 4375-4392, 2019 05 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30927008
7.
Bicyclic ß-Sheet Mimetics that Target the Transcriptional Coactivator ß-Catenin and Inhibit Wnt Signaling.
Angew Chem Int Ed Engl
; 60(25): 13937-13944, 2021 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33783110
8.
Lipophilicity trends upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl groups.
Beilstein J Org Chem
; 16: 2141-2150, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32952731
9.
Observing an Antisense Drug Complex in Intact Human Cells by in-Cell NMR Spectroscopy.
Chembiochem
; 20(19): 2474-2478, 2019 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31206961
10.
Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119.
Chembiochem
; 20(24): 2987-2990, 2019 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31680402
11.
Exploring weak ligand-protein interactions by long-lived NMR states: improved contrast in fragment-based drug screening.
Angew Chem Int Ed Engl
; 53(42): 11376-80, 2014 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25196717
12.
Development of a Series of Pyrrolopyridone MAT2A Inhibitors.
J Med Chem
; 67(6): 4541-4559, 2024 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38466661
13.
Metabolism-driven in vitro/in vivo disconnect of an oral ERÉ VHL-PROTAC.
Commun Biol
; 7(1): 563, 2024 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38740899
14.
Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists.
J Med Chem
; 66(4): 2918-2945, 2023 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36727211
15.
Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models.
J Med Chem
; 65(4): 3306-3331, 2022 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35133824
16.
Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2 receptor antagonist useful for treatment of sleep disorders.
Bioorg Med Chem Lett
; 21(18): 5562-7, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21831639
17.
Nuclear magnetic resonance free ligand conformations and atomic resolution dynamics.
Magn Reson (Gott)
; 2(1): 489-498, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-37904764
18.
Quantification of magic angle spinning dynamic nuclear polarization NMR spectra.
J Magn Reson
; 329: 107030, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34245958
19.
Antisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and extracellular vesicle recycling.
Commun Biol
; 4(1): 1241, 2021 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34725463
20.
Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model.
J Med Chem
; 64(10): 6814-6826, 2021 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33900758