1.
Bull Exp Biol Med
; 149(1): 82-5, 2010 Jul.
Artigo
em Inglês, Russo
| MEDLINE
| ID: mdl-21113465
RESUMO
The development of malignant neoplasm of the head and neck is related to the state of intracellular proteasome system. Elevation of total activity of proteasomes and specific activity of 20S proteasomal pool are accompanied by changes in proteasomal composition. Tumor size correlated with the content of regulatory proteasomal complex PA28. In the presence of regional metastases, 26S proteasome activity decreases and the content of proteasome immune subunit LMP7 in the tumor increases.