Detalhe da pesquisa
1.
Discovery of novel class of histone deacetylase inhibitors as potential anticancer agents.
Bioorg Med Chem
; 42: 116251, 2021 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34116381
2.
Novel allosteric PARP1 inhibitors for the treatment of BRCA-deficient leukemia.
Med Chem Res
; 29(6): 962-978, 2020 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-33071527
3.
Novel inhibitors of Staphylococcus aureus RnpA that synergize with mupirocin.
Bioorg Med Chem Lett
; 28(6): 1127-1131, 2018 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29463447
4.
Design and synthesis of functionalized piperazin-1yl-(E)-stilbenes as inhibitors of 17α-hydroxylase-C17,20-lyase (Cyp17).
Bioorg Med Chem Lett
; 28(13): 2270-2274, 2018 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29803730
5.
Ribosome-Templated Azide-Alkyne Cycloadditions: Synthesis of Potent Macrolide Antibiotics by In Situ Click Chemistry.
J Am Chem Soc
; 138(9): 3136-44, 2016 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26878192
6.
Design, synthesis, and evaluation of (2S,4R)-Ketoconazole sulfonamide analogs as potential treatments for Metabolic Syndrome.
Bioorg Med Chem Lett
; 26(23): 5825-5829, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27789139
7.
Novel inhibitors of acute, axonal DLK palmitoylation are neuroprotective and avoid the deleterious side effects of cell-wide DLK inhibition.
bioRxiv
; 2024 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38712276
8.
Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials.
J Med Chem
; 67(5): 3467-3503, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38372781
9.
A novel monobactam lacking antimicrobial activity, MC-100093, reduces sex-specific ethanol preference and depressive-like behaviors in mice.
Neuropharmacology
; 232: 109515, 2023 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37001726
10.
Liver Metabolomics and Inflammatory Profiles in Mouse Model of Fentanyl Overdose Treated with Beta-Lactams.
Metabolites
; 13(8)2023 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37623908
11.
4'-Ethynyl-2'-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress.
Mol Cancer Ther
; 2023 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38064712
12.
SAR Probing of KX2-391 Provided Analogues With Juxtaposed Activity Profile Against Major Oncogenic Kinases.
Front Oncol
; 12: 879457, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35669422
13.
"I'll Be Back": The Resurrection of Dezocine.
ACS Med Chem Lett
; 12(6): 961-968, 2021 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34141081
14.
Discovery of Imidazole-Based Inhibitors of Plasmodium falciparum cGMP-Dependent Protein Kinase.
ACS Med Chem Lett
; 12(12): 1962-1967, 2021 Dec 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34917261
15.
The Resurrection of Phenotypic Drug Discovery.
ACS Med Chem Lett
; 11(10): 1820-1828, 2020 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33062159
16.
Discovery and SAR of Novel Disubstituted Quinazolines as Dual PI3Kalpha/mTOR Inhibitors Targeting Breast Cancer.
ACS Med Chem Lett
; 11(11): 2156-2164, 2020 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33214824
17.
3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as potent non-peptidic inhibitors of caspase-3.
Bioorg Med Chem
; 17(22): 7755-68, 2009 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19836248
18.
Non-NAD-like PARP-1 inhibitors in prostate cancer treatment.
Biochem Pharmacol
; 167: 149-162, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30880062
19.
Correlating efficacy in rodent cognition models with in vivo 5-hydroxytryptamine1a receptor occupancy by a novel antagonist, (R)-N-(2-methyl-(4-indolyl-1-piperazinyl)ethyl)-N-(2-pyridinyl)-cyclohexane carboxamide (WAY-101405).
J Pharmacol Exp Ther
; 325(1): 134-45, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18182558
20.
A Mitochondrial-targeted purine-based HSP90 antagonist for leukemia therapy.
Oncotarget
; 8(68): 112184-112198, 2017 Dec 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29348817