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1.
CJEM ; 24(2): 219-223, 2022 03.
Artigo em Inglês | MEDLINE | ID: mdl-34964933

RESUMO

BACKGROUND: Quality assurance review is an integral part of point-of-care ultrasound (POCUS) programs but may not be routine practice in community hospitals. Lack of image acquisition and documentation can result in suboptimal patient care. In cases with an adverse outcome and no record of images, there is no mechanism for quality improvement. OBJECTIVES: Our goal was to implement a system of POCUS image archiving in a community hospital. Our SMART (Specific, Measurable, Actionable, Realistic, Timely) aim was to have > 50% of emergency department (ED) POCUS users archiving scans, and > 80% of all billed POCUS scans archived, measuring improvements bi-weekly over a period of 9 months. METHODS: The study was conducted at a single-community ED between August 2020 and April 2021. The POCUS archiving workflow was developed and refined through multiple plan-do-study-act (PDSA) cycles. Surveys, stakeholder meetings, audits, and feedback were used to generate and re-evaluate the interventions. These included introduction of QPathE© software, streamlining of the workflow process, strategic machine placement, POCUS rounds, use of a website for POCUS workflow instructions, and dissemination of audit results. Scans were tracked biweekly, and indexed by the number of scans billed. The primary outcome measure was the number of POCUS scans archived per 100 scans billed. RESULTS: Over a 9-month period, spanning 72,986 ED visits, 550 scans were archived. The percentage of POCUS users who changed practice to consistently archiving scans was 51%. The rate of POCUS scans archived per 100 scans billed was > 80%, compared to no archiving at baseline. CONCLUSION: We were able to transition from a system with entirely unarchived POCUS scanning, to one with > 80% of scans archived over a period of 9 months. This is the first published paper documenting implementation of a POCUS image archiving system in a Canadian Community ED.


RéSUMé: CONTEXTE: L'examen de l'assurance qualité fait partie intégrante des programmes d'échographie au point d'intervention (POCUS), peut ne pas être une pratique courante dans les hôpitaux communautaires. L'absence d'acquisition et de documentation d'images peut entraîner des soins sous-optimaux pour le patient. Dans les cas où l'issue est défavorable et où il n'y a pas d'enregistrement des images, il n'existe aucun mécanisme d'amélioration de la qualité. OBJECTIFS: Notre objectif était de mettre en place un système d'archivage des images POCUS dans un hôpital communautaire. Notre objectif SMART (Specific, Measurable, Actionable, Realistic, Timely) était de faire en sorte que > 50% des utilisateurs de POCUS aux urgences archivent les scans, et que > 80% de tous les scans POCUS facturés soient archivés, en mesurant les améliorations toutes les deux semaines sur une période de 9 mois. MéTHODES: L'étude a été menée dans une seule urgence communautaire entre août 2020 et avril 2021. Le flux de travail de l'archivage POCUS a été développé et affiné à travers de multiples cycles Planification- Exécution­Étude­Action (PEEA) [en anglais Plan-Do-Study-Act (PDSA)]. Des sondages, des réunions de parties prenantes, des audits et des commentaires ont été utilisés pour générer et réévaluer les interventions. Il s'agit notamment de l'introduction du logiciel QPathE©, de la rationalisation du processus de flux de travail, de l'emplacement stratégique des machines, des tournées POCUS, de l'utilisation d'un site web pour les instructions de flux de travail POCUS et de la diffusion des résultats des audits. Les scans étaient suivis toutes les deux semaines et indexés en fonction du nombre de scans facturés. Le principal critère d'évaluation était le nombre de scans POCUS archivés pour 100 scans facturés. RéSULTATS: Sur une période de 9 mois, couvrant 72 986 visites aux urgences, 550 scanners ont été archivés. Le pourcentage d'utilisateurs de POCUS qui ont changé de pratique pour archiver systématiquement les scans était de 51 %. Le taux de scanners POCUS archivés pour 100 scanners facturés était > 80%, par rapport à l'absence d'archivage au départ. CONCLUSION: Nous avons pu passer d'un système où les scanners POCUS n'étaient pas du tout archivés à un système où plus de 80% des scanners ont été archivés sur une période de 9 mois. Il s'agit du premier article publié sur la mise en œuvre d'un système d'archivage d'images POCUS dans une urgence communautaire canadienne.


Assuntos
Sistemas Automatizados de Assistência Junto ao Leito , Testes Imediatos , Canadá , Serviço Hospitalar de Emergência , Humanos , Ultrassonografia/métodos
2.
Immunol Res ; 35(1-2): 41-54, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-17003508

RESUMO

The first studies of mice deficient in lymphotoxin-alpha (LTalpha), LTbeta and LTbetaR revealed the seminal discovery that the LTbetaR signaling is critical for the development of lymph nodes and Peyer's patches during embryogenesis. Since these initial findings, it is increasingly appreciated that signaling through the lymphotoxin-beta receptor (LTbetaR) plays a key role in numerous biological processes in the adult animal, including the maintenance of specialized stromal cell types and the homeostatic control of chemokine expression within the lymphoid tissues. A major focus of our laboratory is to understand the relevance of LTbetaR signaling in initiating immune responses both dependent and independent of its role in maintaining the organization of lymphoid tissues. This review will therefore explore new possibilities for how this complex pathway regulates humoral and cellular immunity.


Assuntos
Linfotoxina-alfa/metabolismo , Proteínas de Membrana/metabolismo , Receptores do Fator de Necrose Tumoral/metabolismo , Fator de Necrose Tumoral alfa/metabolismo , Animais , Imunidade , Linfonodos/crescimento & desenvolvimento , Receptor beta de Linfotoxina , Linfotoxina-alfa/genética , Camundongos , Receptores do Fator de Necrose Tumoral/genética , Membro 14 da Superfamília de Ligantes de Fatores de Necrose Tumoral
3.
Cell Immunol ; 241(2): 85-94, 2006 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-16987502

RESUMO

BAFF is a peripheral B cell survival factor and can mediate antibody (Ab) class switching. Over-expression of BAFF in mice results in B cell hyperplasia, elevated serum immunoglobulin (Ig), spontaneous germinal centre (GC) reactions and mild glomerulonephritis (GN). Here we show that, in addition to driving excessive levels of serum IgA, BAFF over-expression results in increased IgA levels within the intestinal lamina propria (LP) and deposition of IgA immune complexes in the renal glomerular mesangium. LIGHT has been previously shown to mediate a similar phenotype via signaling through the lymphotoxin-beta receptor (LTbetaR). We evaluated if LIGHT and BAFF cooperate in the etiology of a hyper-IgA syndrome in BAFF-overexpressing transgenic (BAFF-Tg) mice. We find that LIGHT-deficient BAFF-Tg mice exhibit similar levels of IgA in the serum, gut and kidney and develop nephritis to the same degree as LIGHT-sufficient BAFF-Tg mice. Therefore, in the context of BAFF over-expression, LIGHT is dispensable for the generation of a hyper-IgA syndrome accompanied by nephritis.


Assuntos
Receptor do Fator Ativador de Células B/metabolismo , Imunoglobulina A/imunologia , Intestino Delgado/patologia , Rim/imunologia , Mucosa/patologia , Membro 14 da Superfamília de Ligantes de Fatores de Necrose Tumoral/metabolismo , Envelhecimento/imunologia , Animais , Autoanticorpos/imunologia , Linfócitos B/citologia , Centro Germinativo/imunologia , Hiperplasia/imunologia , Imunoglobulina A/sangue , Intestino Delgado/citologia , Rim/citologia , Rim/patologia , Receptor beta de Linfotoxina/metabolismo , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Transgênicos , Mucosa/citologia , Fenótipo , Transdução de Sinais , Síndrome , Membro 14 da Superfamília de Ligantes de Fatores de Necrose Tumoral/deficiência
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