Detalhe da pesquisa
1.
Human PLD structures enable drug design and characterization of isoenzyme selectivity.
Nat Chem Biol
; 16(4): 391-399, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32042197
2.
Mechanisms of Regulation and Diverse Activities of Tau-Tubulin Kinase (TTBK) Isoforms.
Cell Mol Neurobiol
; 41(4): 669-685, 2021 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-32424773
3.
Analysis of a vinculin homolog in a sponge (phylum Porifera) reveals that vertebrate-like cell adhesions emerged early in animal evolution.
J Biol Chem
; 293(30): 11674-11686, 2018 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-29880641
4.
Molecular functions of the TLE tetramerization domain in Wnt target gene repression.
EMBO J
; 33(7): 719-31, 2014 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24596249
5.
Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand.
BMC Struct Biol
; 16(1): 7, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27246200
6.
The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)-N-(6-methylpyrazolo[1,5-a]pyrimidin-3-yl)imidazo[1,2-a]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke.
J Med Chem
; 67(6): 4676-4690, 2024 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38467640
7.
A Tiny Pocket Packs a Punch: Leveraging Pyridones for the Discovery of CNS-Penetrant Aza-indazole IRAK4 Inhibitors.
ACS Med Chem Lett
; 15(5): 714-721, 2024 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38746903
8.
Discovery of BIO-8169âA Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation.
J Med Chem
; 67(10): 8383-8395, 2024 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38695469
9.
Elucidation of the GSK3α Structure Informs the Design of Novel, Paralog-Selective Inhibitors.
ACS Chem Neurosci
; 14(6): 1080-1094, 2023 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36812145
10.
Reactive oxygen species regulate nucleostemin oligomerization and protein degradation.
J Biol Chem
; 286(13): 11035-46, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21242306
11.
Discovery of Phospholipase D Inhibitors with Improved Drug-like Properties and Central Nervous System Penetrance.
ACS Med Chem Lett
; 13(4): 665-673, 2022 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35450377
12.
Discovery of Potent Selective Nonzinc Binding Autotaxin Inhibitor BIO-32546.
ACS Med Chem Lett
; 12(7): 1124-1129, 2021 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34267882
13.
Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo.
J Med Chem
; 64(9): 6358-6380, 2021 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33944571
14.
The crystal structure of the catalytic domain of tau tubulin kinase 2 in complex with a small-molecule inhibitor.
Acta Crystallogr F Struct Biol Commun
; 76(Pt 3): 103-108, 2020 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32133995
15.
The transcription factor Spn1 regulates gene expression via a highly conserved novel structural motif.
J Mol Biol
; 404(1): 1-15, 2010 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-20875428
16.
The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure.
Nat Struct Mol Biol
; 15(10): 1122-4, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18794842
17.
A charged and contoured surface on the nucleosome regulates chromatin compaction.
Nat Struct Mol Biol
; 14(11): 1105-7, 2007 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17965723
18.
Kaposi's sarcoma-associated herpesvirus LANA hitches a ride on the chromosome.
Cell Cycle
; 5(10): 1048-52, 2006 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-16721045
19.
The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA.
Science
; 311(5762): 856-61, 2006 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-16469929
20.
Nucleosome assembly protein 1 exchanges histone H2A-H2B dimers and assists nucleosome sliding.
J Biol Chem
; 280(3): 1817-25, 2005 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-15516689