1.
Bioorg Med Chem Lett
; 18(23): 6062-6, 2008 Dec 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18954985
RESUMO
A series of 3,3-disubstituted pyrrolidine monoamine triple reuptake inhibitors were discovered. Analogues with low nanomolar potency, good human in vitro microsomal stability and in vitro permeability, and low drug-drug interaction potential are described. One example showed in vivo anti-depressant-like effects in the mouse tail suspension assay with a minimum effective dose of 30 mg/kg i.p.