RESUMO
The present study evaluated the incidence and risk factors that correlated with the development of non-nucleoside reverse transcriptase inhibitor (NNRTI) related rash in 69 Thai children followed prospectively. The overall incidence of NNRTI-related rash was 16% (22% for NVP and 4% for EFV rash). The only significant predictive factor that correlated with the development of NNRTI-related rash in a multivariate logistic regression model was a CD4% decrease at week 12.
Assuntos
Fármacos Anti-HIV/efeitos adversos , Exantema/induzido quimicamente , Transcriptase Reversa do HIV/antagonistas & inibidores , Inibidores da Transcriptase Reversa/efeitos adversos , Antirretrovirais/efeitos adversos , Contagem de Linfócito CD4 , Criança , Pré-Escolar , Exantema/epidemiologia , Exantema/etiologia , Feminino , Transcriptase Reversa do HIV/efeitos dos fármacos , Humanos , Masculino , Estudos Prospectivos , Fatores de Risco , Tailândia/epidemiologiaRESUMO
We evaluated whether FLAVORx helped thirty Thai children take opened capsule, crushed tablets and liquid generic ARVs with more ease. All children had excellent adherence, evaluated by PACTG Standard International Questionnaire and interviewing, before and after one month of FLAVORx. Eighty percent took ARV with more ease and wish to continue FLAVORx. Strawberry was the most popular flavor.