Diosgenyl 2-amino-2-deoxy-ß-D-galactopyranoside: synthesis, derivatives and antimicrobial activity.

The synthesis of diosgenyl 2-amino-2-deoxy-ß-D-galactopyranoside is presented for the first time. This synthetic saponin was transformed into its hydrochloride as well as N-acyl, 2-ureido, N-alkyl, and N,N-dialkyl derivatives. Antifungal and antibacterial studies show that some of the obtained compounds are active against Gram-positive bacteria and Candida type fungi.