Detalhe da pesquisa
1.
Preclinical to Human Translational Pharmacology of the Novel M1 Positive Allosteric Modulator MK-7622.
J Pharmacol Exp Ther
; 365(3): 556-566, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29563325
2.
Linearity of ß-cell response across the metabolic spectrum and to pharmacology: insights from a graded glucose infusion-based investigation series.
Am J Physiol Endocrinol Metab
; 310(11): E865-73, 2016 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27072496
3.
The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake.
Cell Metab
; 7(1): 68-78, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18177726
4.
Odanacatib, a selective cathepsin K inhibitor to treat osteoporosis: safety, tolerability, pharmacokinetics and pharmacodynamics--results from single oral dose studies in healthy volunteers.
Br J Clin Pharmacol
; 75(5): 1240-54, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23013236
5.
Pharmacokinetic-pharmacodynamic studies of the 11ß-hydroxysteroid dehydrogenase type 1 inhibitor MK-0916 in healthy subjects.
Br J Clin Pharmacol
; 76(6): 917-31, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23594227
6.
Multiple-dose administration of sitagliptin, a dipeptidyl peptidase-4 inhibitor, does not alter the single-dose pharmacokinetics of rosiglitazone in healthy subjects.
J Clin Pharmacol
; 47(2): 159-64, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17244766
7.
Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes.
J Clin Endocrinol Metab
; 91(11): 4612-9, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16912128
8.
Safety, tolerability and pharmacokinetics of doravirine, a novel HIV non-nucleoside reverse transcriptase inhibitor, after single and multiple doses in healthy subjects.
Antivir Ther
; 20(4): 397-405, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25470746