Detalhe da pesquisa
1.
GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain.
Proc Natl Acad Sci U S A
; 118(31)2021 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34330837
2.
In vitro ADME characterization of a very potent 3-acylamino-2-aminopropionic acid-derived GluN2C-NMDA receptor agonist and its ester prodrugs.
Biol Chem
; 404(4): 255-265, 2023 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36427206
3.
Erythrina Alkaloid Analogues as nAChR Antagonists-A Flexible Platform for Leads in Drug Discovery.
J Org Chem
; 86(12): 8248-8262, 2021 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34061521
4.
Pharmacological Characterization of a Betaine/GABA Transporter 1 (BGT1) Inhibitor Displaying an Unusual Biphasic Inhibition Profile and Anti-seizure Effects.
Neurochem Res
; 45(7): 1551-1565, 2020 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-32248400
5.
Identification of AICP as a GluN2C-Selective N-Methyl-d-Aspartate Receptor Superagonist at the GluN1 Glycine Site.
Mol Pharmacol
; 92(2): 151-161, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28588066
6.
Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors.
Mol Pharmacol
; 89(2): 253-62, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26661043
7.
Positive allosteric modulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptors differentially modulates the behavioural effects of citalopram in mouse models of antidepressant and anxiolytic action.
Behav Pharmacol
; 27(6): 549-55, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27341500
8.
The labeling of unsaturated γ-hydroxybutyric acid by heavy isotopes of hydrogen: iridium complex-mediated H/D exchange by CâH bond activation vs reduction by boro-deuterides/tritides.
J Labelled Comp Radiopharm
; 59(12): 476-483, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27593893
9.
In Vitro and In Vivo Evidence for Active Brain Uptake of the GHB Analog HOCPCA by the Monocarboxylate Transporter Subtype 1.
J Pharmacol Exp Ther
; 354(2): 166-74, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25986445
10.
Structure activity relationship of selective GABA uptake inhibitors.
Bioorg Med Chem
; 23(10): 2480-8, 2015 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25882526
11.
α4ßδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB).
Proc Natl Acad Sci U S A
; 109(33): 13404-9, 2012 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22753476
12.
Dissecting the binding mode of low affinity phage display peptide ligands to protein targets by hydrogen/deuterium exchange coupled to mass spectrometry.
Anal Chem
; 86(23): 11734-41, 2014 Dec 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25325890
13.
Analogues of 3-hydroxyisoxazole-containing glutamate receptor ligands based on the 3-hydroxypyrazole-moiety: design, synthesis and pharmacological characterization.
Neurochem Res
; 39(10): 1895-905, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24848194
14.
Pharmacological identification of a guanidine-containing ß-alanine analogue with low micromolar potency and selectivity for the betaine/GABA transporter 1 (BGT1).
Neurochem Res
; 39(10): 1988-96, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24852577
15.
Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-D-aspartate receptors.
Mol Pharmacol
; 84(1): 114-27, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23625947
16.
A tandem chemoenzymatic methylation by S-adenosyl-L-methionine.
Chembiochem
; 14(8): 950-3, 2013 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-23650044
17.
Chemoenzymatic synthesis and in situ application of S-adenosyl-L-methionine analogs.
Org Biomol Chem
; 11(43): 7606-10, 2013 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24100405
18.
Pharmacological characterization and modeling of the binding sites of novel 1,3-bis(pyridinylethynyl)benzenes as metabotropic glutamate receptor 5-selective negative allosteric modulators.
Mol Pharmacol
; 82(5): 929-37, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22899869
19.
Inhibitor scaffold for the histone lysine demethylase KDM4C (JMJD2C).
Bioorg Med Chem Lett
; 22(18): 5811-3, 2012 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22917519
20.
Discovery of (R)-2-amino-3-triazolpropanoic acid derivatives as NMDA receptor glycine site agonists with GluN2 subunit-specific activity.
Front Chem
; 10: 1008233, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36465862