1.
Bioorg Med Chem Lett
; 21(6): 1670-4, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21324685
RESUMO
There is an urgent need for the development of novel antimicrobial agents that offer effective treatment against MRSA. Using a new class of dipeptide antibiotic TAN-1057A/B as lead, we designed, synthesized and evaluated analogs of TAN-1057A/B. Several novel dihydropyrimidinone antibiotics demonstrating comparable antibiotic efficacy while possessing favorable selectivity were identified.