Detalhe da pesquisa
1.
In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor.
Haematologica
; 106(7): 1979-1987, 2021 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32586904
2.
Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome.
Cell Mol Life Sci
; 73(4): 883-900, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26346493
3.
CD86 expression as a surrogate cellular biomarker for pharmacological inhibition of the histone demethylase lysine-specific demethylase 1.
Anal Biochem
; 442(1): 104-6, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23911524
4.
Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia.
Nat Cancer
; 2(10): 1002-1017, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34790902
5.
AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models.
Mol Cancer Ther
; 6(8): 2209-19, 2007 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-17699718
6.
Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells.
J Med Chem
; 59(24): 11120-11137, 2016 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28002956
7.
Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis.
J Med Chem
; 58(6): 2834-44, 2015 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25738750
8.
Transcriptional pathway signatures predict MEK addiction and response to selumetinib (AZD6244).
Cancer Res
; 70(6): 2264-73, 2010 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20215513
9.
Genomics and the search for novel biomarkers in toxicology.
Biomarkers
; 8(2): 79-92, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12775494