Chemical Stability of Lorazepam Oral Solution Repackaged in Plastic Oral Syringes at Room and Refrigerated Temperature.

Purpose: Generic lorazepam oral solution is supplied in a 30 mL multi-dose bottle requiring protection from light and refrigeration, with a beyond use date of 90 days once the bottle is opened. The repackaging of 1 mL doses of lorazepam oral solution into oral syringes allows for facilitated dispensing, yet no available data supports repackaging and storing lorazepam oral solution in syringes. The validation and application of a stability-indicating high-performance liquid chromatography with ultraviolet detection (HPLC-UV) method for the quantification of lorazepam allowed for the determination of the stability of lorazepam oral solution when stored in oral syringes. Methods: A stability-indicating HPLC-UV method was developed for the quantification of lorazepam in oral solution. The method was validated using guidance from USP < 1225 >. For the stability investigation, 2 mg/mL lorazepam oral solution was aliquoted into clear plastic oral syringes in 1 mLmilliliter doses from 2 multi-dose stock bottles and randomly allocated for storage in room temperature or refrigerated environment. Baseline lorazepam concentrations were measured on the day the study was initiated and designated as 100% initial concentration samples. Subsequent samples were analyzed in triplicate at time points of 24, 48, and 96 hours and 7, 10, 14, 21, 30, and 60 days. Results: The calibration curves on three non-consecutive days met the linearity criteria of R 2 > 0.99. Inter- day and intra-day precision and accuracy (percent relative standard deviation and percent error) were ≤2% over three days. During the stability investigation, percent initial concentration of lorazepam from room and refrigerated syringes remained above 90% for the duration of the study. Conclusion: The stability-indicating HPLC-UV method was successfully applied to the investigation of lorazepam oral solution stability when stored in syringes at room and refrigerated temperatures. The emergent need for use of lorazepam concentrate for inpatients and the restrictions of how the medication is supplied necessitated a need for the evaluation of repackaging into unit dose syringes for immediate availability from automated dispensing cabinets. Lorazepam oral solution stored in clear plastic syringes maintained greater than 90% initial concentration at both room and refrigerated temperatures for 60 days.

Reconstruction of the time-dependent wave function exclusively from position data.

A method is presented that reconstructs the amplitude and phase of an unknown time-dependent pure-state wave function entirely from experimental position data. No assumptions about the wave function are needed. At a series of times, a large collection of position data is taken, but no measurements of momentum or energy are necessary. The momenta, however, are required for the reconstruction of the wave function and are supplied by analysis of the position data via quantum particle trajectories. Simulations of the method are provided for helium atoms in single and double slit experiments.

Two Systems, One Population:: Achieving Equity in Mental Healthcare for Criminal Justice and Marginalized Populations.

The mental health system is often not readily accessible, culturally responsive, or a reliable source of effective interventions for society's most vulnerable populations. Modern-era studies estimate the number of persons diagnosed with serious mental illness in correctional facilities is more than 3 times the amount in hospitals. Understanding mass incarceration and the criminalization of mental illness is imperative to address mental health inequities. This article examines the interplay of mental health and criminal justice inequities, the historical context for the prevailing extant approaches to correctional mental health treatment, and programmatic approaches to addressing these inequities.

Repeatability of the modified Oxford foot model during gait in healthy adults.

BACKGROUND: The Oxford foot model (OFM) is a multi-segment model for calculating hindfoot and forefoot motion. Limited information is available regarding the repeatability and error of this model in adults. Therefore the purpose of this study was to assess the intra-tester reliability of OFM hindfoot and forefoot gait kinematics in adults at initial contact (IC) and toe-off (TO). METHODS: Seventeen healthy adults (age=25.1±4.8 years, height=1.75±0.10m, weight=74.0±12.4kg) were tested on a single visit, during which 1 examiner recorded 2 sessions. For each session, 10 walking trials were recorded using a 12-camera motion analysis system (Vicon, Oxford, UK). Markers were removed and re-applied between sessions. Dynamic hindfoot and forefoot angles were calculated both with and without referencing to neutral stance (assuming neutral stance angles are zero in all planes). Using the 10 trial average, intraclass correlation coefficients (ICC(2,k)) and standard errors of the measurement were calculated for each reference condition, anatomical plane, and joint (hindfoot, forefoot). RESULTS: Referencing to neutral stance resulted in good reliability (ICC≥0.83) and small error (≤2.45°) for hindfoot and forefoot angle in all planes. Without referencing to neutral stance, sagittal and transverse plane reliability were also good (ICC≥0.90) and error small (≤3.14°); however, frontal plane reliability was poor (ICC≤0.77), with large error (≥4.86°). DISCUSSION: Our results show that overall the OFM is reliable during adult gait. Reliability for adults is higher than previously reported in children. Referencing joint angles to neutral stance decreased error by up to 2° from previous reports.