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1.
Comp Med ; 70(2): 183-189, 2020 04 01.
Artigo em Inglês | MEDLINE | ID: mdl-32178759

RESUMO

Klebsiella pneumoniae is a gram-negative bacterium found in the environment and as a commensal in humans and animals. In humans, K. pneumoniae is one of the most serious nosocomial infections encountered currently and is characterized by liver abscesses, pneumonia, and bacteremia resulting in meningoencephalitis and endophthalmitis. K. pneumoniae in veterinary medicine is rarely reported in NHP, and recent literature describing this disease is sparse. In our colony of predominantly outdoor-housed rhesus macaques (Macaca mulatta), K. pneumoniae is cultured infrequently from healthy animals during routine screening and is even rarer in sick animals. This report summarizes the clinical and postmortem findings associated with this pathogen in 9 rhesus macaques and compares these results with the disease outcomes reported for humans. In these cases, K. pneumoniae infection was confirmed through culture or PCR testing or both. In our experience, when this bacterium does cause clinical signs, the disease is rapidly progressive and severe. At necropsy of NHP, the findings are strikingly similar to opportunistic Klebsiella-associated syndromes described in humans and include liver abscesses, meningoencephalitis, and endophthalmitis. In addition, many of the affected macaques had similar risk factors to humans that succumb to disease, thus perhaps indicating that rhesus macaques could be a viable model for investigating these syndromes.


Assuntos
Infecções por Klebsiella/veterinária , Doenças dos Macacos/diagnóstico , Pneumonia Bacteriana/veterinária , Animais , Antibacterianos/uso terapêutico , Feminino , Infecções por Klebsiella/diagnóstico , Infecções por Klebsiella/tratamento farmacológico , Infecções por Klebsiella/microbiologia , Klebsiella pneumoniae/isolamento & purificação , Macaca mulatta , Masculino , Doenças dos Macacos/tratamento farmacológico , Doenças dos Macacos/microbiologia , Pneumonia Bacteriana/diagnóstico , Pneumonia Bacteriana/tratamento farmacológico , Pneumonia Bacteriana/microbiologia
2.
Basic Clin Androl ; 27: 4, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28191316

RESUMO

BACKGROUND: Options for male contraception are limited. The purpose of this study was to use a nonhuman primate model to evaluate Vasalgel™, a high molecular weight polymer being developed as a contraceptive device for men. METHODS: Sixteen adult male rhesus monkeys received intravas injections of Vasalgel, consisting of 25% styrene maleic acid in dimethyl sulfoxide. After a one-week recovery, males were returned to outdoor group housing, which included at least 3 and up to 9 intact, breeding females with a successful reproductive history. RESULTS: Treated males have had no conceptions since Vasalgel injections. All males were housed with intact females for at least one breeding season and seven have been almost continually housed with females for 2 years. Complications were minor and included one incident of incorrect placement of Vasalgel into the vas deferens and the development of a sperm granuloma in one animal. Three unilateral vasectomies were performed, one was necessary for incorrect placement of Vasalgel, the other two were elective. CONCLUSIONS: Intravas injection of Vasalgel in sexually mature adult male rhesus monkeys was effective in preventing conception in a free-living, group environment. Complications were few and similar to those associated with traditional vasectomy.

3.
Comp Med ; 65(6): 537-9, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26678372

RESUMO

A 20-y-old female cynomolgus macaque (Macaca fascicularis) housed in an indoor primate facility presented for poor appetite and acute weakness after several years of no adverse health events. Physical examination revealed a firm, ovoid mass in the caudal abdomen. Further evaluation revealed the mass to be a vaginal calculus composed of calcium carbonate, apatite, and struvite. To our knowledge, this case is the first reported description of a vaginal stone in an NHP.


Assuntos
Cálculos/diagnóstico , Doenças Vaginais/diagnóstico , Animais , Feminino , Humanos , Macaca fascicularis
4.
J Wildl Dis ; 40(1): 137-40, 2004 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-15137502

RESUMO

Raptors are commonly infected with two blood parasites of the family Haemoproteidae, Haemoproteus spp. and Leukocytozoon spp. To determine if age or length of time in captivity influence prevalence of Haemoproteus spp. and Leukocytozoon spp. infection in captive raptors, blood samples were collected from 55 birds from April 1999 to May 2000. Blood smears were examined for parasitemia and influence of age and length of time in captivity at the time of sample collection were compared. We found juvenile and adult birds were more likely to be infected with Leukocytozoon spp. than were nestlings (P = 0.006) and birds present for > 365 days were more likely to be infected with Haemoproteus spp. and/or Leukocytozoon spp. than were birds captive for < 365 days.


Assuntos
Doenças das Aves/epidemiologia , Haemosporida , Parasitemia/veterinária , Infecções Protozoárias em Animais/epidemiologia , Aves Predatórias/parasitologia , Fatores Etários , Animais , Animais Domésticos , Doenças das Aves/parasitologia , Feminino , Haemosporida/isolamento & purificação , Masculino , Parasitemia/epidemiologia , Parasitemia/parasitologia , Prevalência , Fatores de Tempo
5.
J Wildl Dis ; 38(1): 7-17, 2002 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-11838231

RESUMO

The sensitivity and specificity of the microscopic agglutination test (MAT) as a method for detection of exposure to Leptospira spp. in California sea lions (Zalophus californianus) were determined. Sera came from individuals that demonstrated clinical signs of renal disease, had lesions suggestive of leptospirosis at necropsy, and had visible leptospires in silver stained kidney sections as positive controls. Sera from unexposed captive individuals were used as negative controls. The test was 100% sensitive at 1:3,200 for confirming renal infection and 100% specific at negative < 1:100 for detection of Leptospira interrogans scrovar pomona antibodies by MAT in California sea lions. Leptospira interrogans serovar pomona was used as a screening serovar because it has been isolated previously from the kidneys and placentas of California sea lions, and there appears to be cross-reactivity between serovar pomona and other serovars. Sera from 225 free-ranging California sea lions presented to one of three participating California (USA) coastal marine mammal rehabilitation centers in 1996 were then evaluated for antibodies to serovar pomona using the MAT. The overall seroprevalence was 38.2% (86/225), although the prevalence varied among locations from 100% (38/38) in animals at the Marine Mammal Care Center (Fort MacArthur, California, USA) to 0% (0/14) at SeaWorld California (San Diego, California). At The Marine Mammal Center (Sausalito, California) [prevalence 27.8% (48/173)], the majority of seropositive animals were subadults and adults, and males were 4.7 times more likely to be seropositive to serovar pomona than females. When combining results from all three centers, subadult and adult animals were more likely to be seropositive than pups and juvenile sea lions, and the highest proportion of seropositive animals presented during the autumn months. Serum elevations of blood urea nitrogen, creatinine, phosphorus, and/or calcium were associated with seropositivity to serovar pomona. We found no association between potassium or sodium levels and seropositivity.


Assuntos
Testes de Aglutinação/veterinária , Anticorpos Antibacterianos/sangue , Leptospira interrogans/imunologia , Leptospirose/veterinária , Leões-Marinhos , Testes de Aglutinação/métodos , Testes de Aglutinação/normas , Animais , California/epidemiologia , Reações Cruzadas , Feminino , Rim/microbiologia , Rim/patologia , Leptospirose/diagnóstico , Leptospirose/epidemiologia , Masculino , Reprodutibilidade dos Testes , Estações do Ano , Sensibilidade e Especificidade , Estudos Soroepidemiológicos , Caracteres Sexuais
6.
J Am Assoc Lab Anim Sci ; 53(5): 523-7, 2014 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-25255076

RESUMO

A 5.5-y-old male rhesus monkey (Macaca mulatta) housed in an outdoor field cage presented for severe trauma involving the left calcaneal tendon. Part of the management of this wound included an allograft of the calcaneal tendon from an animal that was euthanized for medical reasons. This case report describes the successful medical and surgical management of a macaque with a significant void of the calcaneal tendon. To our knowledge, this report is the first description of a successful tendon allograft in a rhesus macaque for clinical purposes.


Assuntos
Aloenxertos , Macaca mulatta , Traumatismos dos Tendões/veterinária , Tendões/transplante , Animais , Abrigo para Animais , Masculino , Comportamento Social , Traumatismos dos Tendões/cirurgia , Traumatismos dos Tendões/terapia
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