Detalhe da pesquisa
1.
Targeting tau only extracellularly is likely to be less efficacious than targeting it both intra- and extracellularly.
Semin Cell Dev Biol
; 126: 125-137, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34896021
2.
Increased neuronal activity in motor cortex reveals prominent calcium dyshomeostasis in tauopathy mice.
Neurobiol Dis
; 147: 105165, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33166699
3.
Two novel Tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce Tau protein pathology.
J Biol Chem
; 288(46): 33081-95, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24089520
4.
Antibody uptake into neurons occurs primarily via clathrin-dependent Fcγ receptor endocytosis and is a prerequisite for acute tau protein clearance.
J Biol Chem
; 288(49): 35452-65, 2013 Dec 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-24163366
5.
Single-domain antibody-based protein degrader for synucleinopathies.
Mol Neurodegener
; 19(1): 44, 2024 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-38816762
6.
Single-Domain Antibody-Based Protein Degrader for Synucleinopathies.
bioRxiv
; 2024 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38558982
7.
Tau isoform composition influences rate and extent of filament formation.
J Biol Chem
; 287(24): 20711-9, 2012 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22539343
8.
Tau-targeting therapies for Alzheimer disease: current status and future directions.
Nat Rev Neurol
; 19(12): 715-736, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37875627
9.
Single-domain antibody-based noninvasive in vivo imaging of α-synuclein or tau pathology.
Sci Adv
; 9(19): eadf3775, 2023 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37163602
10.
Single domain antibodies targeting pathological tau protein: Influence of four IgG subclasses on efficacy and toxicity.
EBioMedicine
; 84: 104249, 2022 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-36099813
11.
Inhibition of tau polymerization with a cyanine dye in two distinct model systems.
J Biol Chem
; 284(31): 20830-9, 2009 Jul 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-19478088
12.
Dynamics of Internalization and Intracellular Interaction of Tau Antibodies and Human Pathological Tau Protein in a Human Neuron-Like Model.
Front Neurol
; 11: 602292, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33324339
13.
Structural characterization of monoclonal antibodies targeting C-terminal Ser404 region of phosphorylated tau protein.
MAbs
; 11(3): 477-488, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30794086
14.
Tau antibody chimerization alters its charge and binding, thereby reducing its cellular uptake and efficacy.
EBioMedicine
; 42: 157-173, 2019 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-30910484
15.
Is tau aggregation toxic or protective?
J Alzheimers Dis
; 14(4): 453-7, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18688098
16.
Sex Differences in Autophagy Contribute to Female Vulnerability in Alzheimer's Disease.
Front Neurosci
; 12: 372, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29988365
17.
Tau-targeting therapies for Alzheimer disease.
Nat Rev Neurol
; 14(7): 399-415, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29895964
18.
Pathways of tau fibrillization.
Biochim Biophys Acta
; 1739(2-3): 167-78, 2005 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-15615636
19.
Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy.
Mol Neurodegener
; 11(1): 62, 2016 08 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-27578006
20.
Evaluating triggers and enhancers of tau fibrillization.
Microsc Res Tech
; 67(3-4): 141-55, 2005 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16103995