Detalhe da pesquisa
1.
Discovery of a Potent Deubiquitinase (DUB) Small-Molecule Activity-Based Probe Enables Broad Spectrum DUB Activity Profiling in Living Cells.
Angew Chem Int Ed Engl
; 62(47): e202311190, 2023 11 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37779326
2.
UCHL1 as a novel target in breast cancer: emerging insights from cell and chemical biology.
Br J Cancer
; 126(1): 24-33, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34497382
3.
Structure-activity relationships of 2-pyrimidinecarbohydrazides as utrophin modulators for the potential treatment of Duchenne muscular dystrophy.
Bioorg Med Chem
; 69: 116812, 2022 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35772287
4.
Synthesis and structure-activity relationships for tetrahydroisoquinoline-based inhibitors of Mycobacterium tuberculosis.
Bioorg Med Chem
; 28(22): 115784, 2020 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33007562
5.
Discovery of a novel fluorescent chemical probe suitable for evaluation of neuropilin-1 binding of small molecules.
Drug Dev Res
; 81(4): 491-500, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31958155
6.
Synthetic Studies to Help Elucidate the Metabolism of the Preclinical Candidate TBAJ-876-A Less Toxic and More Potent Analogue of Bedaquiline.
Molecules
; 25(6)2020 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32245020
7.
3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel.
Bioorg Med Chem
; 27(7): 1292-1307, 2019 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30803745
8.
Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline.
Bioorg Med Chem
; 27(7): 1283-1291, 2019 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30792104
9.
Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles.
Bioorg Med Chem
; 26(8): 1797-1809, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29482950
10.
Fatty Acid-Derived Pro-Toxicants of the Rat Selective Toxicant Norbormide.
Chem Biodivers
; 13(6): 762-75, 2016 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-27144301
11.
Synthesis and methemoglobinemia-inducing properties of benzocaine isosteres designed as humane rodenticides.
Bioorg Med Chem
; 22(7): 2220-35, 2014 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24602400
12.
Discovery of potent and selective activity-based probes (ABPs) for the deubiquitinating enzyme USP30.
RSC Chem Biol
; 5(5): 439-446, 2024 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38725909
13.
Structure-Guided Design and Optimization of Covalent VHL-Targeted Sulfonyl Fluoride PROTACs.
J Med Chem
; 67(6): 4641-4654, 2024 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38478885
14.
Synthesis and methemoglobinemia-inducing properties of analogues of para-aminopropiophenone designed as humane rodenticides.
Bioorg Med Chem Lett
; 23(24): 6629-35, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24210502
15.
Prodrugs of N-dicarboximide derivatives of the rat selective toxicant norbormide.
Bioorg Med Chem
; 21(18): 5886-99, 2013 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23920483
16.
A Series of Substituted Bis-Aminotriazines Are Activators of the Natriuretic Peptide Receptor C.
J Med Chem
; 65(7): 5495-5513, 2022 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35333039
17.
Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis.
Eur J Med Chem
; 229: 114059, 2022 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34963068
18.
Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs).
Chem Commun (Camb)
; 58(78): 10933-10936, 2022 Sep 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-36065962
19.
A tubulin binding molecule drives differentiation of acute myeloid leukemia cells.
iScience
; 25(8): 104787, 2022 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35992086
20.
The maturation of DNA encoded libraries: opportunities for new users.
Future Med Chem
; 13(2): 173-191, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33275046