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1.
Am J Emerg Med ; 35(11): 1630-1635, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-28511807

RESUMO

OBJECTIVE: Prehospital personnel who lack advanced airway management training must rely on basic techniques when transporting unconscious trauma patients. The supine position is associated with a loss of airway patency when compared to lateral recumbent positions. Thus, an inherent conflict exists between securing an open airway using the recovery position and maintaining spinal immobilization in the supine position. The lateral trauma position is a novel technique that aims to combine airway management with spinal precautions. The objective of this study was to compare the spinal motion allowed by the novel lateral trauma position and the well-established log-roll maneuver. METHODS: Using a full-body cadaver model with an induced globally unstable cervical spine (C5-C6) lesion, we investigated the mean range of motion (ROM) produced at the site of the injury in six dimensions by performing the two maneuvers using an electromagnetic tracking device. RESULTS: Compared to the log-roll maneuver, the lateral trauma position caused similar mean ROM in five of the six dimensions. Only medial/lateral linear motion was significantly greater in the lateral trauma position (1.4mm (95% confidence interval [CI] 0.4, 2.4mm)). CONCLUSIONS: In this cadaver study, the novel lateral trauma position and the well-established log-roll maneuver resulted in comparable amounts of motion in an unstable cervical spine injury model. We suggest that the lateral trauma position may be considered for unconscious non-intubated trauma patients.


Assuntos
Vértebras Cervicais/lesões , Lesões do Pescoço/terapia , Posicionamento do Paciente/métodos , Amplitude de Movimento Articular , Traumatismos da Coluna Vertebral/terapia , Idoso , Idoso de 80 Anos ou mais , Manuseio das Vias Aéreas/métodos , Fenômenos Biomecânicos , Cadáver , Estudos Cross-Over , Serviços Médicos de Emergência/métodos , Feminino , Humanos , Disco Intervertebral/lesões , Ligamento Amarelo/lesões , Ligamentos Longitudinais/lesões , Masculino , Pessoa de Meia-Idade , Medula Espinal , Fraturas da Coluna Vertebral , Decúbito Dorsal
2.
Prehosp Emerg Care ; 18(4): 539-43, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24878332

RESUMO

STUDY OBJECTIVE: To compare the amount of segmental vertebral motion produced with the lateral recovery position and the HAINES technique when performed on cadavers with destabilized cervical spines. METHODS: The cervical spines of 10 cadavers were surgically destabilized at the C5-C6 vertebral segment. Sensors from an electromagnetic tracking device were affixed to the vertebrae in question to monitor the amount of anterior/posterior, medial/lateral, and distraction/compression linear motion produced during the application of the two study techniques. RESULTS: The statistical analysis of linear motion data did not reveal any significant differences between the two recovery positions. CONCLUSION: At this time, no single version of the recovery position can be endorsed for the spine-injured trauma patient. More research is needed to fully ascertain the safety of commonly used recovery positions.


Assuntos
Vértebras Cervicais/lesões , Imobilização , Amplitude de Movimento Articular/fisiologia , Traumatismos da Coluna Vertebral/fisiopatologia , Transporte de Pacientes/métodos , Idoso , Idoso de 80 Anos ou mais , Cadáver , Feminino , Humanos , Imobilização/métodos , Masculino , Postura , Medição de Risco
3.
Vet Surg ; 43(1): 58-65, 2014 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-24527494

RESUMO

OBJECTIVE: To compare biomechanical properties of (1) 4.5 mm cortical screws and Fitz Fenestrated Tubular Transcondylar (F2T2) screws; (2) normal humeri and humeri with an intracondylar osteotomy; and (3) humeri with an intracondylar osteotomy stabilized with either a 4.5 mm cortical screw or a F2T2 screw. STUDY DESIGN: Cadaveric biomechanical assessment. SAMPLE POPULATION: 4.5 mm cortical screws (n = 10), 5.85 mm F2T2 screws (n = 10), and paired dog humeri (n = 40). METHODS: Cortical and F2T2 screws were loaded to failure in 3-point bending. Ten pairs of humeri with or without an intracondylar osteotomy were axially loaded to failure. Ten additional pairs of humeri with an intracondylar osteotomy were alternately stabilized with a positional cortical or F2T2 screw and axially loaded to failure. RESULTS: Mean stiffness, yield load, and failure load was significantly greater (P < .001) for the F2T2 screws compared with cortical screws as well as for intact humeri compared with humeri with an intracondylar osteotomy (P < .001). There were no significant differences in mean stiffness (P = .59), yield load (P = .31), or failure load (P = .24) between humeri with stabilized intracondylar osteotomy. CONCLUSION: Isolated F2T2 screws have superior mechanical properties to 4.5 mm cortical screws when loaded in 3-point bending. Intracondylar osteotomy adversely affected humeral mechanical integrity. Osteotomized humeri stabilized by either screw had comparable mechanical properties.


Assuntos
Parafusos Ósseos/veterinária , Cães/cirurgia , Úmero/cirurgia , Osteotomia/veterinária , Animais , Fenômenos Biomecânicos , Osteogênese , Osteotomia/instrumentação , Suporte de Carga
4.
Anesth Analg ; 117(1): 126-32, 2013 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-23354337

RESUMO

BACKGROUND: The effects of advanced airway management on cervical spine alignment in patients with upper cervical spine instability are uncertain. METHODS: To examine the potential for mechanical disruption during endotracheal intubation in cadavers with unstable cervical spines, we performed a prospective observational cohort study with 3 cadaver subjects. We created an unstable, type II odontoid fracture with global ligamentous instability at C1-2 in lightly embalmed cadavers, followed by repetitive intubations with 4 different airway devices (Airtraq laryngoscope, Lightwand, intubating laryngeal mask airway [LMA], and Macintosh laryngoscope) while manual in-line stabilization was applied. Motion analysis data were collected using an electromagnetic device to assess the degree of angular movement in 3 axes (flexion-extension, axial rotation, and lateral bending) during the intubation trials with each device. Intubation was performed by either an emergency medical technician or attending anesthesiologist. RESULTS: Overall, 153 intubations were recorded with the 4 devices. The Lightwand technique resulted in significantly less flexion-extension and axial rotation at C1-2 than with the intubating LMA (mean difference in flexion-extension 3.2° [95% confidence interval {CI}, 0.9°-5.5°], P = 0.003; mean difference in axial rotation 1.6° [95% CI, 0.3°-2.8°], P = 0.01) and Macintosh laryngoscope (mean difference in flexion-extension 3.1° [95% CI, 0.8°-5.4°], P = 0.005; mean difference in axial rotation 1.4° [95% CI 0.1°-2.6°], P = 0.03). CONCLUSIONS: In cadavers with instability at C1-2, the Lightwand technique produced less motion than the Macintosh and intubating LMA.


Assuntos
Intubação Intratraqueal/instrumentação , Intubação Intratraqueal/métodos , Instabilidade Articular , Ligamentos/lesões , Processo Odontoide/lesões , Fraturas da Coluna Vertebral , Idoso , Idoso de 80 Anos ou mais , Vértebras Cervicais/lesões , Estudos de Coortes , Humanos , Intubação Intratraqueal/normas , Instabilidade Articular/complicações , Máscaras Laríngeas/normas , Estudos Prospectivos , Fraturas da Coluna Vertebral/complicações
5.
BMC Vet Res ; 9: 125, 2013 Jun 24.
Artigo em Inglês | MEDLINE | ID: mdl-23800317

RESUMO

BACKGROUND: There are several factors that can affect the fatigue life of a bone plate, including the mechanical properties of the plate and the complexity of the fracture. The position of the screws can influence construct stiffness, plate strain and cyclic fatigue of the implants. Studies have not investigated these variables in implants utilized for long bone fracture fixation in dogs and cats. The purpose of the present study was to evaluate the effect of plate working length on construct stiffness, gap motion and resistance to cyclic fatigue of dog femora with a simulated fracture gap stabilized using a 12-hole 2.4 mm locking compression plates (LCP). Femora were plated with 12-hole 2.4 mm LCP using 2 screws per fracture segment (long working length group) or with 12-hole 2.4 mm LCP using 5 screws per fracture segment (a short working length group). RESULTS: Construct stiffness did not differ significantly between stabilization techniques. Implant failure did not occur in any of the plated femora during cycling. Mean ± SD yield load at failure in the short plate working length group was significantly higher than in the long plate working length group. CONCLUSION: In a femoral fracture gap model stabilized with a 2.4 mm LCP applied in contact with the bone, plate working length had no effect on stiffness, gap motion and resistance to fatigue. The short plate working length constructs failed at higher loads; however, yield loads for both the short and long plate working length constructs were within physiologic range.


Assuntos
Placas Ósseas/veterinária , Cães/cirurgia , Fraturas do Fêmur/veterinária , Fêmur/cirurgia , Fixação Interna de Fraturas/veterinária , Animais , Placas Ósseas/normas , Fraturas do Fêmur/cirurgia , Fixação Interna de Fraturas/métodos , Distribuição Aleatória , Estresse Mecânico , Gravação em Vídeo
6.
J Spinal Cord Med ; 36(1): 58-65, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23433336

RESUMO

CONTEXT: Excessive spinal motion generated during multiple bed transfers of patients with unstable spine injuries may contribute to neurological deterioration. OBJECTIVE: To evaluate spinal motion in a cadaveric model of global spinal instability during hospital bed transfers using several commonly used techniques. DESIGN/PARTICIPANTS: A motion analysis and evaluation of hospital bed transfer techniques in a cadaveric model of C5-C6 and T12-L2 global spinal instability. Setting/outcome measures: Global instability at C5-C6 and T12-L2 was created. The motion in three planes was measured in both the cervical and lumbar spine during each bed transfer via electromagnetic motion detection devices. Comparisons between transfers performed using an air-assisted lateral transfer device, manual transfer, a rolling board, and a sliding board were made based on the maximum range of motion observed. RESULTS: Significantly less lateral bending at C5-C6 was observed in air-assisted device transfers when compared with the two other boards. Air-assisted device transfers produced significantly less axial rotation at T12-L2 than the rolling board, and manual transfers produced significantly less thoracolumbar rotation than both the rolling and sliding boards. No other significant differences were observed in cervical or lumbar motion. Motion versus time plots indicated that the log roll maneuvers performed during rolling board and sliding board transfers contributed most of the observed motion. CONCLUSIONS: Each transfer technique produced substantial motion. Transfer techniques that do not include the logroll maneuver can significantly decrease some components of cervical and lumbar motion. Thus, some spinal motion can be reduced through selection of transfer technique.


Assuntos
Leitos , Equipamentos e Provisões Hospitalares , Movimento (Física) , Movimentação e Reposicionamento de Pacientes , Coluna Vertebral/fisiologia , Transporte de Pacientes/métodos , Fenômenos Biomecânicos/fisiologia , Cadáver , Humanos
7.
J Emerg Med ; 45(3): 366-71, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-23849357

RESUMO

BACKGROUND: As prehospital emergency rescuers prepare cervical spine-injured adult patients for immobilization and transport to hospital, it is essential that patients be placed in a favorable position. Previously, it was recommended that patients with cervical spine injuries be immobilized in a slightly flexed position using pads placed beneath the head. However, it is unknown how neck flexion created with pad placement affects the unstable spine. OBJECTIVE: To determine the effects of three different head positions on the alignment of unstable vertebral segments. METHODS: Five cadavers with a complete segmental instability at the C5 and C6 level were included in the study. The head was either placed directly on the ground (or spine board) or on foam pads. Three conditions were tested: no pad; pads 2.84 cm thick; and pads 4.26 cm thick. Pads were positioned beneath the head to determine their effect on spinal alignment. Anterior-posterior translation, flexion-extension motion, and axial displacement across the unstable segment were compared between conditions. RESULTS: Although statistical tests failed to identify any significant differences between pad conditions, some meaningful results were noted. In general, the "no pad" condition aligned the spine in a position that best replicated the intact spine. CONCLUSIONS: Because the goal of emergency rescuers is to conserve whatever physiologic or structural integrity of the spinal cord and spinal column that remains, the outcome of this study suggests that this goal may be best achieved using the "no pad" condition. However, it is recommended that more research be conducted to confirm these preliminary findings.


Assuntos
Vértebras Cervicais/lesões , Serviços Médicos de Emergência/métodos , Instabilidade Articular/prevenção & controle , Posicionamento do Paciente/métodos , Idoso , Cadáver , Feminino , Humanos , Imobilização , Masculino , Pessoa de Meia-Idade , Transporte de Pacientes , Articulação Zigapofisária/fisiopatologia
8.
Cell Tissue Bank ; 14(4): 673-7, 2013 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-23526125

RESUMO

The purpose of this study was to determine whether the pull-through force of soft-tissue allografts increases over time after being hydrated with saline-soaked sponges. Eighteen aseptic soft-tissue, fresh-frozen anterior tibialis allograft specimens were thawed and sized using standard sizing guides. After sizing, initial pull-through force was measured using an Instron Model 5865 machine. Grafts were randomized to soak in saline sponges for 20, 40, or 60 min. After soaking, pull-through force was again assessed. Pre- and post-soaking pull-through forces were compared using a paired t test. The effect of time on pull-through force was evaluated using an ANOVA and Tukey post hoc test. Two allografts had initial pull-through forces outside the inclusion criteria and were excluded. The average pull-through force for the remaining 16 allografts pre-soaking was 43.0 N and post-soaking was 81.7 N, for an increase of 90 % (P < 0.001). Longer hydration time in the saline soaked sponges was not correlated with higher pull-through force (P = 0.724). Pull-through force post-hydration was not related to the allograft diameter (P = 0.641). Post-hydration, 33 % of grafts that had soaked for 20 min and 40 % of grafts that had soaked for 40 or 60 min required greater than 100 N pull-through force. Our data supports the hypothesis that soft-tissue allografts swell as a result of being stored in saline-soaked sponges, resulting in greater pull-through forces during graft passage. Surgeons should bear in mind that allografts swell when stored in saline-soaked gauze and should size their tunnels accordingly.


Assuntos
Aloenxertos/fisiologia , Reconstrução do Ligamento Cruzado Anterior , Água , Fenômenos Biomecânicos , Humanos , Cloreto de Sódio , Tendões
9.
Cell Tissue Bank ; 14(3): 359-66, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-22972164

RESUMO

One major concern regarding soft tissue allograft use in surgical procedures is the risk of disease transmission. Current techniques of tissue sterilization, such as irradiation have been shown to adversely affect the mechanical properties of soft tissues. Grafts processed using Biocleanse processing (a proprietary technique developed by Regeneration Technologies to sterilize human tissues) will have better biomechanical characteristics than tissues that have been irradiated. Fifteen pairs of cadaveric Achilles tendon allografts were obtained and separated into three groups of 10 each. Three treatment groups were: Biocleanse, Irradiated, and Control (untreated). Each specimen was tested to determine the biomechanical properties of the tissue. Specimens were cyclically preloaded and then loaded to failure in tension. During testing, load, displacement, and optical strain data were captured. Following testing, the cross sectional area of the tendons was determined. Tendons in the control group were found to have a higher extrinsic stiffness (slope of the load-deformation curve, p = .005), have a higher ultimate stress (force/cross sectional area, p = .006) and higher ultimate failure load (p = .003) than irradiated grafts. Biocleanse grafts were also found to be stiffer than irradiated grafts (p = .014) yet were not found to be statistically different from either irradiated or non-irradiated grafts in terms of load to failure. Biocleanse processing seems to be a viable alternative to irradiation for Achilles tendon allografts sterilization in terms of their biomechanical properties.


Assuntos
Aloenxertos/fisiologia , Esterilização/métodos , Tendões/fisiologia , Aloenxertos/efeitos da radiação , Fenômenos Biomecânicos/efeitos da radiação , Demografia , Módulo de Elasticidade/efeitos da radiação , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Radiação Ionizante , Estresse Mecânico , Tendões/efeitos da radiação , Suporte de Carga
10.
Vet Surg ; 42(7): 853-9, 2013 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-24033745

RESUMO

OBJECTIVE: To (1) compare the effect of cyclic loading on craniocaudal tibial translation in cranial cruciate ligament (CrCL)-deficient stifles after extracapsular stabilization, and (2) evaluate the effect of peak force during cyclic loading on the rate of development of craniocaudal laxity. STUDY DESIGN: Biomechanical cadaveric study. SAMPLE POPULATION: Cadaveric pelvic limbs (n = 24 pairs) from skeletally mature dogs. METHODS: Twenty-four pairs of stifles were randomly assigned to 4 stabilization groups: nylon leader lateral circumfabellar-tibial suture (NLS); FiberTape lateral circumfabellar-tibial suture (FTLS); TightRope (TR); or bone anchor (BA). Contralateral limbs were cyclically loaded to produce cranial tibial translation at peak forces of either 80 or 160 N. Craniocaudal displacement of the tibia was measured with a mechanical testing machine during cyclic loading with the CrCL intact, after CrCL transection, and after extracapsular stabilization. The number of cycles each construct underwent before reaching 200% and 300% of the mean craniocaudal displacement present during cyclic loading of the CrCL-intact stifles was calculated. Number of cycles among treatment groups was compared with a Kruskal-Wallis test. P < .05 was considered significant. RESULTS: Mean ± SD translation before and after CrCL transection were 3.9 ± 0.6 and 14.6 ± 1.7 mm, respectively. TR constructs resisted significantly more cycles than NLS constructs before reaching 7.8 mm (200%) and 11.7 mm (300%) of translation when loaded to 80 N. No other differences between constructs were significant at a peak load of 80 N. All constructs reached 7.8 and 11.7 mm of translation in fewer cycles when loaded to 160 N than at 80 N. CONCLUSIONS: TR constructs were most resistant to elongation during cyclic loading. Doubling the peak force during cyclic loading significantly decreased the number of cycles constructs withstood, supporting recommendations for restricting postoperative activity after extracapsular stabilization of the CrCL-deficient stifle.


Assuntos
Cães , Procedimentos Ortopédicos/veterinária , Joelho de Quadrúpedes/cirurgia , Técnicas de Sutura/veterinária , Animais , Ligamento Cruzado Anterior/cirurgia , Fenômenos Biomecânicos , Parafusos Ósseos/veterinária , Cadáver , Procedimentos Ortopédicos/métodos , Estresse Mecânico
11.
J Spinal Cord Med ; 35(1): 53-7, 2012 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-22330191

RESUMO

INTRODUCTION: Previous research has found that the log roll (LR) technique produces significant motion in the spinal column while transferring a supine patient onto a spine board. The purpose of this project was to determine whether log rolling a patient with an unstable spine from prone to supine with a pulling motion provides better thoracolumbar immobilization compared to log rolling with a push technique. METHODS: A global instability was surgically created at the L1 level in five cadavers. Two spine-boarding protocols were tested (LR Push and LR Pull). Both techniques entailed performing a 180° LR rotation of the prone patient from the ground to the supine position on the spine board. An electromagnetic tracking device registered motion between the T12 and L2 vertebral segments. Six motion parameters were tracked. Repeated-measures statistical analysis was performed to evaluate angular and translational motion. RESULTS: Less motion was produced during the LR Push compared to the LR Pull for all six motion parameters. The difference was statistically significant for three of the six parameters (flexion-extension, axial translation, and anterior-posterior (A-P) translation). CONCLUSIONS: Both the LR Push and LR Pull generated significant motion in the thoracolumbar spine during the prone to supine LR. The LR Push technique produced statistically less motion than the LR Pull, and should be considered when a prone patient with a suspected thoracolumbar injury needs to be transferred to a long spine board. More research is needed to identify techniques to further reduce the motion in the unstable spine during prone to supine LR.


Assuntos
Vértebras Lombares/fisiologia , Movimento (Física) , Doenças da Coluna Vertebral/fisiopatologia , Transporte de Pacientes/métodos , Fenômenos Biomecânicos , Cadáver , Humanos , Decúbito Ventral , Amplitude de Movimento Articular/fisiologia , Transporte de Pacientes/normas
12.
Vet Surg ; 41(8): 905-14, 2012 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-23198918

RESUMO

OBJECTIVE: To evaluate the effect of proximal ulnar rotational osteotomy (PURO) on the contact mechanics and 3-dimensional (3D) alignment of cadaveric normal dog elbows. STUDY DESIGN: Ex vivo biomechanical study. ANIMALS: Unpaired thoracic limbs from 12 dogs (mean ± SD weight, 26 ± 4 kg). METHODS: PURO consisted of a transverse osteotomy with 30° external rotation of the proximal segment. With the limb under 200 N axial load, contact area (CA), mean contact pressure (CP) and peak contact pressure (PCP) were measured using digital pressure sensors in the medial and lateral compartments and 3D static elbow poses were obtained, before and after PURO. Each specimen was tested at 115°, 135°, and 155° elbow flexion, with the antebrachium in neutral rotation, in 28° supination, and in 16° pronation. Repeated measures ANOVAs with post-hoc Bonferroni (P ≤ .05) were performed. RESULTS: PURO caused significant changes, mostly at 135° elbow flexion and neutral antebrachial rotation, characterized by decreased CP (10%) and PCP (10%) in the medial compartment, and increased CP (27%) and PCP (23%) in the lateral compartment. The apex of the medial coronoid process translated 3.4 mm caudally, 1.7 mm abaxially, and rotated 1.8° externally relative to the radial head. Humeroradial varus angulation reduced by 6.7°. CONCLUSIONS: In limited poses, PURO displaces the medial coronoid process caudally and abaxially and shifts contact pressures towards the lateral elbow compartment by decreasing varus angulation.


Assuntos
Cães/anatomia & histologia , Cães/cirurgia , Membro Anterior/anatomia & histologia , Membro Anterior/fisiologia , Articulações/anatomia & histologia , Osteotomia/veterinária , Animais , Fenômenos Biomecânicos , Cadáver , Membro Anterior/cirurgia , Articulações/fisiologia , Articulações/cirurgia , Osteotomia/métodos
13.
Vet Surg ; 41(7): 818-28, 2012 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-22957539

RESUMO

OBJECTIVE: To evaluate the effects of antebrachial rotation at 3 elbow flexion angles on contact mechanics and 3-dimensional (3D) alignment of normal dog elbows. STUDY DESIGN: Ex vivo biomechanical study. ANIMALS: Unpaired thoracic limbs from 18 dogs (mean ± SD weight, 27 ± 4 kg). METHODS: With the limb under 200 N axial load, digital pressure sensors measured contact area (CA), mean contact pressure (MCP), peak contact pressure (PCP), and PCP location in the medial and lateral elbow compartments, and 3D static poses of the elbow were obtained. Each specimen was tested at 115°, 135°, and 155° elbow flexion, with the antebrachium in a neutral position, in 28° supination, and in 16° pronation. Repeated measure ANOVAs with post-hoc Bonferroni (P ≤ .0167) were performed. RESULTS: Both pronation and supination decreased CA by 16% and 8% and increased PCP by 5% and 10% in the medial and lateral compartments, respectively. PCP location moved 2.3 mm (1.8-3.2 mm) closer to the apex of the medial coronoid process in pronation and 2.0 mm (1.8-2.2 mm) farther away in supination. The radial head and medial coronoid process rotated 5.4° and 1.9° internally during pronation and 7.2° and 1.2° externally during supination. CONCLUSIONS: Contact mechanics and 3D alignment of normal dog elbows varied significantly at different elbow poses.


Assuntos
Cães/anatomia & histologia , Cães/fisiologia , Membro Anterior/anatomia & histologia , Membro Anterior/fisiologia , Articulações/anatomia & histologia , Articulações/fisiologia , Animais , Fenômenos Biomecânicos , Cadáver
14.
Am J Physiol Endocrinol Metab ; 300(4): E650-60, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21266670

RESUMO

Selective androgen receptor modulators (SARMs) now under development can protect against muscle and bone loss without causing prostate growth or polycythemia. 17ß-Hydroxyestra-4,9,11-trien-3-one (trenbolone), a potent testosterone analog, may have SARM-like actions because, unlike testosterone, trenbolone does not undergo tissue-specific 5α-reduction to form more potent androgens. We tested the hypothesis that trenbolone-enanthate (TREN) might prevent orchiectomy-induced losses in muscle and bone and visceral fat accumulation without increasing prostate mass or resulting in adverse hemoglobin elevations. Male F344 rats aged 3 mo underwent orchiectomy or remained intact and were administered graded doses of TREN, supraphysiological testosterone-enanthate, or vehicle for 29 days. In both intact and orchiectomized animals, all TREN doses and supraphysiological testosterone-enanthate augmented androgen-sensitive levator ani/bulbocavernosus muscle mass by 35-40% above shams (P ≤ 0.001) and produced a dose-dependent partial protection against orchiectomy-induced total and trabecular bone mineral density losses (P < 0.05) and visceral fat accumulation (P < 0.05). The lowest doses of TREN successfully maintained prostate mass and hemoglobin concentrations at sham levels in both intact and orchiectomized animals, whereas supraphysiological testosterone-enanthate and high-dose TREN elevated prostate mass by 84 and 68%, respectively (P < 0.01). In summary, low-dose administration of the non-5α-reducible androgen TREN maintains prostate mass and hemoglobin concentrations near the level of shams while producing potent myotrophic actions in skeletal muscle and partial protection against orchiectomy-induced bone loss and visceral fat accumulation. Our findings indicate that TREN has advantages over supraphysiological testosterone and supports the need for future preclinical studies examining the viability of TREN as an option for androgen replacement therapy.


Assuntos
Adiposidade/efeitos dos fármacos , Osso e Ossos/efeitos dos fármacos , Hemoglobinas/efeitos dos fármacos , Músculos/efeitos dos fármacos , Próstata/efeitos dos fármacos , Acetato de Trembolona/farmacologia , Adiposidade/fisiologia , Anabolizantes/farmacologia , Animais , Osso e Ossos/anatomia & histologia , Osso e Ossos/metabolismo , Avaliação Pré-Clínica de Medicamentos , Hemoglobinas/metabolismo , Terapia de Reposição Hormonal , Masculino , Músculos/anatomia & histologia , Músculos/metabolismo , Orquiectomia , Tamanho do Órgão/efeitos dos fármacos , Especificidade de Órgãos/efeitos dos fármacos , Projetos Piloto , Próstata/anatomia & histologia , Próstata/metabolismo , Ratos , Ratos Endogâmicos F344 , Testosterona/farmacologia
15.
J Trauma ; 70(5): 1282-5; discussion 1285, 2011 May.
Artigo em Inglês | MEDLINE | ID: mdl-21610441

RESUMO

BACKGROUND: After spine board immobilization of the trauma victim and transport to the hospital, the patient is removed from the spine board as soon as practical. Current Advanced Trauma Life Support's recommendations are to log roll the patient 90 degrees, remove the spine board, inspect and palpate the back, and then log roll back to supine position. There are several publications showing unacceptable motion in an unstable spine when log rolling. METHODS: Cervical spine motion was evaluated during spine board removal. A C5 to C6 instability was surgically created in cadavers. A three-dimensional electromagnetic tracking system was used to assess motion between C5 and C6. The log roll was compared with a lift-and-slide technique. Throughout the log roll procedure, manual inline cervical stabilization was provided by a trained individual in a series of trials. In other trials, the lift-and-slide technique was used. In the final stage, the amount of motion generated was assessed when the spine board removal techniques were completed by experienced and novice persons in maintaining inline stabilization of the head and neck. RESULTS: Motion between C5 and C6 was reduced during the lift-and-slide technique in five of six parameters. The reduction was statistically significant in four parameters. When performing the log roll, motion was not reduced with increased head holder experience. CONCLUSIONS: Spine boards can be removed using a lift-and-slide maneuver with less motion and potentially less risk to the patient's long-term neurologic function than expected using the log roll.


Assuntos
Vértebras Cervicais/lesões , Imobilização/instrumentação , Remoção , Movimento (Física) , Equipamentos Ortopédicos , Traumatismos da Coluna Vertebral/terapia , Transporte de Pacientes/métodos , Fenômenos Biomecânicos , Cadáver , Vértebras Cervicais/fisiopatologia , Humanos , Traumatismos da Coluna Vertebral/fisiopatologia
16.
J Emerg Med ; 41(5): 513-9, 2011 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-21397431

RESUMO

BACKGROUND: Cervical orthoses are commonly used for extrication, transportation, and definitive immobilization for cervical trauma patients. Various designs have been tested frequently in young, healthy individuals. To date, no one has reported the effectiveness of collar immobilization in the presence of an unstable mid-cervical spine. STUDY OBJECTIVES: To determine the extent to which cervical orthoses immobilize the cervical spine in a cadaveric model with and without a spinal instability. METHODS: This study used a repeated-measures design to quantify motion on multiple axes. Five lightly embalmed cadavers with no history of cervical pathology were used. An electromagnetic motion-tracking system captured segmental motion at C5-C6 while the spine was maneuvered through the range of motion in each plane. Testing was carried out in intact conditions after a global instability was created at C5-C6. Three collar conditions were tested: a one-piece extraction collar (Ambu Inc., Linthicum, MD), a two-piece collar (Aspen Sierra, Aspen Medical Products, Irvine, CA), and no collar. Gardner-Wells tongs were affixed to the skull and used to apply motion in flexion-extension, lateral bending, and rotation. Statistical analysis was carried out to evaluate the conditions: collar use by instability (3 × 2). RESULTS: Neither the one- nor the two-piece collar was effective at significantly reducing segmental motion in the stable or unstable condition. There was dramatically more motion in the unstable state, as would be expected. CONCLUSION: Although using a cervical collar is better than no immobilization, collars do not effectively reduce motion in an unstable cervical spine cadaver model. Further study is needed to develop other immobilization techniques that will adequately immobilize an injured, unstable cervical spine.


Assuntos
Braquetes/normas , Vértebras Cervicais/lesões , Imobilização/instrumentação , Instabilidade Articular/terapia , Fenômenos Biomecânicos , Cadáver , Fenômenos Eletromagnéticos , Humanos , Pessoa de Meia-Idade , Adulto Jovem
17.
Am J Emerg Med ; 28(7): 751-6, 2010 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-20837250

RESUMO

INTRODUCTION: In the prehospital setting, spine-injured patients must be transferred to a spine board to immobilize the spine. This can be accomplished using both manual techniques and mechanical devices. OBJECTIVES: The study aimed to evaluate the effectiveness of the scoop stretcher to limit cervical spine motion as compared to 2 commonly used manual transfer techniques. METHODS: Three-dimensional angular motion generated across the C5-C6 spinal segment during execution of 2 manual transfer techniques and the application of a scoop stretcher was recorded first on cadavers with intact spines and then repeated after C5-C6 destabilization. A 3-dimensional electromagnetic tracking device was used to measure the maximum angular and linear motion produced during all test sessions. RESULTS: Although not statistically significant, the execution of the log roll maneuver created more motion in all directions than either the lift-and-slide technique or with scoop stretcher application. The scoop stretcher and lift-and-slide techniques were able to restrict motion to a comparable degree. CONCLUSION: The effectiveness of the scoop stretcher to limit spinal motion in the destabilized spine is comparable or better than manual techniques currently being used by primary responders.


Assuntos
Vértebras Cervicais , Serviços Médicos de Emergência/métodos , Movimentação e Reposicionamento de Pacientes/instrumentação , Traumatismos da Coluna Vertebral , Idoso de 80 Anos ou mais , Análise de Variância , Fenômenos Biomecânicos , Cadáver , Vértebras Cervicais/lesões , Fenômenos Eletromagnéticos , Desenho de Equipamento , Humanos , Imageamento Tridimensional , Imobilização/instrumentação , Amplitude de Movimento Articular , Rotação , Segurança , Traumatismos da Coluna Vertebral/diagnóstico , Traumatismos da Coluna Vertebral/fisiopatologia , Traumatismos da Coluna Vertebral/prevenção & controle , Transporte de Pacientes/métodos
18.
J Trauma ; 69(2): 432-6, 2010 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-20699754

RESUMO

BACKGROUND: Hospital bed transfers, moves to examination room, X-ray, hospital bed, and/or surgery, have the potential of causing harm to a patient with an unstable cervical spine. This study evaluated motion generated in an unstable segment of the cervical spine during hospital bed transfers. A secondary goal purpose was to assess reduction in cervical motion using three collars and a no collar condition. METHODS: Cervical spine instability was created at C5-C6 in cadavers. A repeated measures design was used to compare bed transfer techniques: manual transfer performed by six trained individuals and a transfer made by two people using the On3 lateral transfer device. Both techniques were tested under four collar conditions. Cervical spine motion was measured using an electromagnetic motion analysis device with sensors fixed to the anterior bodies of C5 and C6. RESULTS: No significant differences were observed between transfer techniques (flexion, [p = 0.325]; axial rotation [p = 0.590]; lateral bending [p = 0.112]). Nor were there significant differences among the three collars used (flexion [p = 0.462]; axial rotation [p = 0.434]; lateral bending [p = 0.250]). For all transfers, using no collar resulted in more motion than using a collar; but was not statistically significant. CONCLUSIONS: Bed transfers made with a lateral transfer device seem to be as safe as those made by the lift and slide manual transfer. None of the collars tested were significantly better at preventing cervical spine motion during a transfer, but each allowed less movement than no collar.


Assuntos
Vértebras Cervicais/fisiopatologia , Imobilização/instrumentação , Instabilidade Articular/etiologia , Instabilidade Articular/fisiopatologia , Movimentação e Reposicionamento de Pacientes/efeitos adversos , Aparelhos Ortopédicos , Transferência de Pacientes/métodos , Cadáver , Humanos , Modelos Biológicos , Movimento (Física) , Movimentação e Reposicionamento de Pacientes/métodos , Probabilidade , Traumatismos da Coluna Vertebral/complicações
19.
Vet Surg ; 39(3): 363-70, 2010 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-20522216

RESUMO

OBJECTIVE: To assess contact mechanics and 3-dimensional (3-D) joint alignment in cranial cruciate ligament (CCL)-deficient stifles before and after tibial plateau leveling osteotomy (TPLO) and tibial tuberosity advancement (TTA) with the stifle in 90 degrees of flexion. STUDY DESIGN: In vitro biomechanical study. SAMPLE POPULATION: Cadaveric pelvic limb pairs (n=8) from dogs weighing 28-35 kg. METHODS: Contralateral limbs were assigned to receive TPLO or TTA. Digital pressure sensors were used to measure femorotibial contact area, peak and mean contact pressure, and peak pressure location with the limb under a load of 30% body weight and stifle flexion angle of 90 degrees . 3-D poses were obtained using a Microscribe digitizer. Specimens were tested under normal, CCL deficient, and treatment conditions. RESULTS: Significant disturbances in alignment were not observed after CCL transection, although medial contact area was 10% smaller than normal (P=.003). There were no significant differences in contact mechanics or alignment between normal and TTA conditions; TPLO induced 6 degrees varus angulation (P<.001), 26% decrease in lateral peak pressure (P=.027), and 18% increase in medial mean pressure (P=.008) when compared with normal. CONCLUSION: Cranial tibial subluxation is nominal in CCL-deficient stifles loaded in flexion. Stifle alignment and contact mechanics are not altered by TTA, whereas TPLO causes mild varus and a subsequent increase in medial compartment loading. CLINICAL RELEVANCE: Cranial tibial subluxation of CCL-deficient stifles may not occur during postures that load the stifle in flexion. The significance of minor changes in loading patterns after TPLO is unknown.


Assuntos
Ligamento Cruzado Anterior/cirurgia , Doenças do Cão/cirurgia , Osteotomia/veterinária , Joelho de Quadrúpedes/cirurgia , Tíbia/cirurgia , Animais , Ligamento Cruzado Anterior/fisiopatologia , Fenômenos Biomecânicos/fisiologia , Doenças do Cão/fisiopatologia , Cães/fisiologia , Cães/cirurgia , Osteotomia/métodos , Amplitude de Movimento Articular/fisiologia , Joelho de Quadrúpedes/fisiopatologia , Suporte de Carga/fisiologia
20.
Vet Surg ; 38(1): 33-9, 2009 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-19152615

RESUMO

Objective- To evaluate the effects of tibial tuberosity advancement (TTA) on femorotibial contact mechanics and 3-dimensional kinematics in cranial cruciate ligament (CrCL)-deficient stifles of dogs. Study Design- In vitro biomechanical study. Animals- Unpaired pelvic limbs from 8 dogs, weighing 28-35 kg. Methods- Digital pressure sensors placed subjacent to the menisci were used to measure femorotibial contact force, contact area, peak and mean contact pressure, and peak pressure location with the limb under an axial load of 30% body weight and a stifle angle of 135 degrees . Three-dimensional static poses of the stifle were obtained using a Microscribe digitizing arm. Each specimen was tested under normal, CrCL-deficient, and TTA-treated conditions. Repeated measures analysis of variance with a Tukey post hoc test (P<.05) was used for statistical comparison. Results- Significant disturbances to all measured contact mechanic parameters were evident after CrCL transection, which corresponded to marked cranial tibial subluxation and internal tibial rotation in the CrCL-deficient stifle. No significant differences in any contact mechanic and kinematic parameters were detected between normal and TTA-treated stifles. Conclusion- TTA eliminates craniocaudal stifle instability during simulated weight-bearing and concurrently restores femorotibial contact mechanics to normal. Clinical Relevance- TTA may mitigate the progression of stifle osteoarthritis in dogs afflicted with CrCL insufficiency by eliminating cranial tibial thrust while preserving the normal orientation of the proximal tibial articulating surface.


Assuntos
Lesões do Ligamento Cruzado Anterior , Cães , Fêmur/cirurgia , Osteotomia/veterinária , Joelho de Quadrúpedes/cirurgia , Tíbia/cirurgia , Análise de Variância , Animais , Ligamento Cruzado Anterior/cirurgia , Fenômenos Biomecânicos , Cadáver , Cães/lesões , Cães/cirurgia , Osteotomia/métodos , Joelho de Quadrúpedes/fisiologia
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