Detalhe da pesquisa
1.
Rescue of hearing by adenine base editing in a humanized mouse model of Usher syndrome type 1F.
Mol Ther
; 31(8): 2439-2453, 2023 08 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37312453
2.
Finding a window for gene therapy for hereditary deafness.
Proc Natl Acad Sci U S A
; 120(39): e2311864120, 2023 09 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37703299
3.
Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing.
EMBO J
; 35(23): 2536-2552, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27458190
4.
Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction.
Nature
; 492(7427): 128-32, 2012 Dec 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23135401
5.
Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia.
Nature
; 481(7382): 520-4, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22246323
6.
Rescue of Hearing by Gene Delivery to Inner-Ear Hair Cells Using Exosome-Associated AAV.
Mol Ther
; 25(2): 379-391, 2017 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28082074
7.
Are TMCs the Mechanotransduction Channels of Vertebrate Hair Cells?
J Neurosci
; 36(43): 10921-10926, 2016 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27798174
8.
Genome-wide association analysis on normal hearing function identifies PCDH20 and SLC28A3 as candidates for hearing function and loss.
Hum Mol Genet
; 24(19): 5655-64, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26188009
9.
Gene Expression by Mouse Inner Ear Hair Cells during Development.
J Neurosci
; 35(16): 6366-80, 2015 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25904789
10.
The zebrafish pinball wizard gene encodes WRB, a tail-anchored-protein receptor essential for inner-ear hair cells and retinal photoreceptors.
J Physiol
; 594(4): 895-914, 2016 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26593130
11.
Noddy, a mouse harboring a missense mutation in protocadherin-15, reveals the impact of disrupting a critical interaction site between tip-link cadherins in inner ear hair cells.
J Neurosci
; 33(10): 4395-404, 2013 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23467356
12.
The auditory midbrain mediates tactile vibration sensing.
bioRxiv
; 2024 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38496510
13.
PCDH15 Dual-AAV Gene Therapy for Deafness and Blindness in Usher Syndrome Type 1F.
bioRxiv
; 2023 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38014037
14.
Mini-PCDH15 gene therapy rescues hearing in a mouse model of Usher syndrome type 1F.
Nat Commun
; 14(1): 2400, 2023 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37100771
15.
Mechanical gating of the auditory transduction channel TMC1 involves the fourth and sixth transmembrane helices.
Sci Adv
; 8(28): eabo1126, 2022 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35857511
16.
Sliding adhesion confers coherent motion to hair cell stereocilia and parallel gating to transduction channels.
J Neurosci
; 30(27): 9051-63, 2010 Jul 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-20610739
17.
Electron Microscopy Techniques for Investigating Structure and Composition of Hair-Cell Stereociliary Bundles.
Front Cell Dev Biol
; 9: 744248, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34746139
18.
Identification of Novel and Recurrent Variants in MYO15A in Ashkenazi Jewish Patients With Autosomal Recessive Nonsyndromic Hearing Loss.
Front Genet
; 12: 737782, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34733312
19.
Single-molecule force spectroscopy reveals the dynamic strength of the hair-cell tip-link connection.
Nat Commun
; 12(1): 849, 2021 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33558532
20.
AAV-S: A versatile capsid variant for transduction of mouse and primate inner ear.
Mol Ther Methods Clin Dev
; 21: 382-398, 2021 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33869656