RESUMO
The aim of this study was to evaluate the effect of local administration of melatonin (MLT) on molecular biomarkers and calvaria bone critical defects in female rats with or without osteoporosis, associated or not with a xenogeneic biomaterial. Forty-eight female rats were randomly divided into two groups: (O) ovariectomized and (S) placebo groups. After 45 days of osteoporosis induction, two critical-size defects (5 mm diameter) were created on the calvaria. The groups were subdivided according to the following treatment: (C) Clot, MLT, MLT associated with Bio-Oss® (MLTBO), and Bio-Oss® (BO). After 45 days, the defect samples were collected and processed for microtomography, histomorphometry, and biomolecular analysis (Col-I, BMP-2, and OPN). All animals had one femur harvested to confirm the osteoporosis. Microtomography analysis demonstrated a bone mineral density reduction in the O group. Regarding bone healing, the S group presented greater filling of the defects than the O group; however, in the O group, the defects treated with MLT showed higher mineral filling than the other treatments. There was no difference between the treatments performed in the S group (p = 0.05). Otherwise, O-MLT had neoformed bone higher than in the other groups (p = 0.05). The groups that did not receive biomaterial demonstrated lower levels of Col-I secretion; S-MLT and S-MLTBO presented higher levels of OPN, while O-C presented statistically lower results (p < 0.05); O-BO showed greater BMP-2 secretion (p < 0.05). In the presence of ovariectomy-induced osteoporosis, MLT treatment increased the newly formed bone area, regulated the inflammatory response, and increased OPN expression.
RESUMO
objetivo: avaliar o grau de satisfação dos pacientes submetidos à cirurgia ortognática, atendidos pelo Serviço de Cirurgia e Traumatologia Buco-Maxilo-Facial de Ponta Grossa, Paraná. Metodologia: Um questionário foi aplicado a 15 pacientes submetidos à cirurgia ortognática. o questionário constava de 20 perguntas sobre o estado de vida antes e depois do procedimento cirúrgico, formuladas para respostas rápidas e com possibilidade de incluir opinião pessoal. Por não se tratar de análise estatística, os dados dos pacientes entrevistados foram lançados no programa Microsoft Excel® e realizados conforme análise qualitativa para serem explanados. Resultados: observou-se uma melhora significativa na autoimagem e autoestima. Conclusão: a grande maioria dos pacientes buscou a cirurgia ortognática por indicação de outros profissionais como seus ortodontistas. o apoio psicológico familiar foi relevante na recuperação dos pacientes. após a cirurgia, os pacientes observaram grandes mudanças nas suas características faciais e também autoestima; Muitos dos problemas estéticos e funcionais que os pacientes relatam antes da cirurgia são sanados após a sua realização; É de suma importância o entrosamento entre os profissionais envolvidos com o tratamento a fim de se obter sucesso. o sucesso se deve, também, ao entendimento por parte do paciente e de seus familiares sobre os passos do tratamento.
Goal: To evaluate the degree of satisfaction degree of patients submitted to orthognatic surgery, attended at the MaxiloFacial Surgery Unit in Ponta Grossa, Paraná. Methodology: a questionnaire was applied to 15 patients submitted to orthognatic surgery. The questionnaire consisted of 20 questions on lifestyle before and after the surgical procedure, and was designed to produce quick answers, with the chance of including personal opinions. as this was not a statistical analysis the patient data from the interviews were launched in Microsoft Excel and submitted to a qualitative analysis. Results: a significant improvement was observed in self-image and self-esteem. Conclusion: The vast majority of the patients decided to undergo orthognatic surgery on the recommendation of other professionals, such as their orthodontist; the family's psychological support was important in the patients' recovery; following surgery the patients noticed major changes in their facial characteristics and also in their self-esteem; many of the aesthetic and functional problems reported by the patients prior to surgery are resolved as a result of the procedure; liaison between the professionals involved in treatment is of crucial importance in achieving success; and success is also due to an understanding of the stages of the treatment on the part of the patient and his or her family.