Detalhe da pesquisa
1.
7-Dehydrocholesterol is an endogenous suppressor of ferroptosis.
Nature
; 626(7998): 401-410, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38297129
2.
Sex-specific hypnotic effects of the neuroactive steroid (3ß,5ß,17ß)-3-hydroxyandrostane-17-carbonitrile are mediated by peripheral metabolism into an active hypnotic steroid.
Br J Anaesth
; 130(2): 154-164, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36428160
3.
A Proinflammatory Stimulus Disrupts Hippocampal Plasticity and Learning via Microglial Activation and 25-Hydroxycholesterol.
J Neurosci
; 41(49): 10054-10064, 2021 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34725187
4.
Nanomolar, Noncovalent Antagonism of Hedgehog Cholesterolysis: Exception to the "Irreversibility Rule" for Protein Autoprocessing Inhibition.
Biochemistry
; 61(11): 1022-1028, 2022 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34941260
5.
The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response.
Immunity
; 38(1): 106-18, 2013 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-23273843
6.
Multiple functional neurosteroid binding sites on GABAA receptors.
PLoS Biol
; 17(3): e3000157, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30845142
7.
Fatty acid synthesis configures the plasma membrane for inflammation in diabetes.
Nature
; 539(7628): 294-298, 2016 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27806377
8.
Structural basis of Smoothened regulation by its extracellular domains.
Nature
; 535(7613): 517-522, 2016 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27437577
9.
General Anesthesia and the Young Brain: The Importance of Novel Strategies with Alternate Mechanisms of Action.
Int J Mol Sci
; 23(3)2022 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35163810
10.
4ß-Hydroxycholesterol is a prolipogenic factor that promotes SREBP1c expression and activity through the liver X receptor.
J Lipid Res
; 62: 100051, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33631213
11.
The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
Nat Chem Biol
; 15(10): 975-982, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31548691
12.
Differential effects of the novel neurosteroid hypnotic (3ß,5ß,17ß)-3-hydroxyandrostane-17-carbonitrile on electroencephalogram activity in male and female rats.
Br J Anaesth
; 127(3): 435-446, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-33972091
13.
The T-type calcium channel isoform Cav3.1 is a target for the hypnotic effect of the anaesthetic neurosteroid (3ß,5ß,17ß)-3-hydroxyandrostane-17-carbonitrile.
Br J Anaesth
; 126(1): 245-255, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32859366
14.
Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis.
Biochemistry
; 59(6): 736-741, 2020 02 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32013401
15.
25-Hydroxycholesterol amplifies microglial IL-1ß production in an apoE isoform-dependent manner.
J Neuroinflammation
; 17(1): 192, 2020 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32552741
16.
Neuroactive steroids alphaxalone and CDNC24 are effective hypnotics and potentiators of GABAA currents, but are not neurotoxic to the developing rat brain.
Br J Anaesth
; 124(5): 603-613, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32151384
17.
Synthesis and characterization of diazirine alkyne probes for the study of intracellular cholesterol trafficking.
J Lipid Res
; 60(3): 707-716, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30617147
18.
Analysis of GABAA Receptor Activation by Combinations of Agonists Acting at the Same or Distinct Binding Sites.
Mol Pharmacol
; 95(1): 70-81, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30337372
19.
Mapping two neurosteroid-modulatory sites in the prototypic pentameric ligand-gated ion channel GLIC.
J Biol Chem
; 293(8): 3013-3027, 2018 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29301936
20.
Novel neurosteroid hypnotic blocks T-type calcium channel-dependent rebound burst firing and suppresses long-term potentiation in the rat subiculum.
Br J Anaesth
; 122(5): 643-651, 2019 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-30916017